DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and prp16

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_595890.2	Gene:	prp16 / 2540006	PomBaseID:	SPBC1711.17	Length:	1173	Species:	Schizosaccharomyces pombe

Alignment Length:	798	Identity:	322/798 - (40%)
Similarity:	479/798 - (60%)	Gaps:	108/798 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKRRIEV-----------GETYGSK------AKKDPEA------------------------SS 24
            |.:||:.:           |..:.||      :.:||::                        ::
pombe   367 MEERRVHLLVDELRPHFLDGAEFSSKKVGDITSVRDPQSDLAINARLGSRLVRERREFRERQKAA 431

  Fly    25 SSAAAAAGT-VAQILG-----------GFVP----------NKQPPTMNPLTNTPYSQRYQNLYK 67
            |:|.:.||| :..::|           |..|          ||:        :|.:: |.::..:
pombe   432 SAATSLAGTSLGNVMGLKDSNDEDAKAGTTPVKVAGRSEQSNKK--------DTEFA-RTKSYRE 487

  Fly    68 KRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSKG--RKG-VSCTQPRRV 129
            :|..||.|..:...:.::..:|.:::|||||||||||:.|    |....|  |.| :.|||||||
pombe   488 QREFLPAFAVREQLLSVIRDNQVLIVVGETGSGKTTQLAQ----FLYEDGYHRNGMIGCTQPRRV 548

  Fly   130 AAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQVILLDE 194
            ||||||:||||||.|:||..|||||||||.:...|::||||||:||||::....|::|.||::||
pombe   549 AAMSVAKRVSEEMGVRLGSTVGYSIRFEDVTGPDTVIKYMTDGVLLRESLMQNNLEKYSVIIMDE 613

  Fly   195 AHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVEIFYTPE 259
            ||||:|.||||||:||:|:.:|.|:||:|.|||:::.||..:|..||...:||||:||:|.:...
pombe   614 AHERSLNTDILMGLLKKVLSRRRDIKLLVTSATMNSQKFSDFFGGAPQFTIPGRTYPVDIMFAKA 678

  Fly   260 PERDYLEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRIKREIDNLGSEIGELKCIPLYST 324
            |..||:|||:|.|:|||:.:. .||||:|:||||:||..|:.|...::.| .:...|..:|:||.
pombe   679 PCSDYVEAAVRQVLQIHLSQP-AGDILVFMTGQEDIEATCEIIADRLNQL-HDAPRLSILPIYSQ 741

  Fly   325 LPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESL 389
            :|.:||.:||:.|.|    |.  |||||:|||||||||:.|:.:|:|.|:.|.|:||.::.:::|
pombe   742 MPADLQAKIFDSAEP----GV--RKVVVATNIAETSLTVHGISYVVDTGYCKLKMYNSKLGIDTL 800

  Fly   390 LVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDD 454
            .|:|||:|:|.||:||||||.||..:|||||.|:..||.:.|.|||.|:||...||.||.||:::
pombe   801 QVTPISQANANQRAGRAGRTGPGIAYRLYTEMAYIREMFETTLPEIQRTNLSNTVLILKSLGVEE 865

  Fly   455 LVHFDFMDPPAPETLMRALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNE 519
            :..|||||.|..:|||.:|..|..|.|||:.|.||.||..||.||:||.|:|::|.:..:.|:.|
pombe   866 ISDFDFMDRPPNDTLMASLYELWTLGALDNFGKLTTLGKKMSLFPMDPSLSKLIIIAEDYKCTEE 930

  Fly   520 ILSITAMLSVPQCFVRPNEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQSSEDPNWCYENFINF 584
            |::|.:|||||..|.||.|..:.:|.|:.:|...:.|||.|||:|..::::....:||.::|::.
pombe   931 IITIVSMLSVPSVFYRPKERAEESDAAREKFNVPESDHLMLLNIYQHWQRNGYSNSWCSKHFLHS 995

  Fly   585 RSLKSADNVRQQLARIMDRFNLRRTSTEFTSKDYYVNIRKALVQGFFMQVAHLERTGYYLTIKDN 649
            ::||.|.::||||..||.:   ::.|.|..| |:.: :|:.|...:|.|.|..:..|.|:.::..
pombe   996 KTLKRARDIRQQLVEIMSK---QKISLESVS-DWDI-VRRVLCSAYFHQAACAKGIGEYVHLRSG 1055

  Fly   650 QNVQLHPSTC---LDHKPDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLAPQYYDLNNFPQCEAKR 711
            ....||.::.   |.:.||:|||:|.|||:|.|:..||.|.|.||......||.:..
pombe  1056 MPCHLHVTSSLYGLGYLPDYVIYHELVLTSKEYMNIVTSVDPYWLAEFGGVYYSVKE-------- 1112

  Fly   712 QLELLQQRLETKQYQKGF 729
                 :.|.||:.|.:.|
pombe  1113 -----RFRNETESYDRVF 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	14/51 (27%)
		DEXDc	67..255	CDD:214692	102/190 (54%)
		DEXDc	91..228	CDD:238005	85/139 (61%)
		HELICc	315..408	CDD:197757	46/92 (50%)
		HA2	478..561	CDD:214852	37/82 (45%)
		OB_NTP_bind	595..698	CDD:285018	36/105 (34%)
prp16	NP_595890.2	DEXDc	487..673	CDD:214692	102/189 (54%)
		DEXDc	509..647	CDD:238005	86/141 (61%)
		HELICc	718..821	CDD:197757	50/109 (46%)
		HA2	890..972	CDD:214852	37/81 (46%)
		OB_NTP_bind	998..1107	CDD:285018	40/113 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
TreeFam	0	0.000	Not matched by this tool.
	5	4.710