DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dhx15 and Ythdc2

DIOPT Version :10

Sequence 1:NP_610269.1 Gene:Dhx15 / 35654 FlyBaseID:FBgn0033160 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001156485.1 Gene:Ythdc2 / 240255 MGIID:2448561 Length:1445 Species:Mus musculus


Alignment Length:909 Identity:236/909 - (25%)
Similarity:376/909 - (41%) Gaps:290/909 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 NPLTNTPYSQRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVS 115
            |.:...|..:........|.:|||||.|.:.::::..::.:::||||||||||||||:.:|....
Mouse   187 NGIPQVPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFK 251

  Fly   116 KGRK-GVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAM 179
            .|.. .:.||||||:||::||:||:.|...::|:.:||.||.|...:.||||.:.|:|:|||..|
Mouse   252 NGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLM 316

  Fly   180 S-DPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLM 243
            : |..|.....:::||.|||...:|.|:..|::::::...|||::.||.||...|.:||.:.|::
Mouse   317 AGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVI 381

  Fly   244 KVPGRTHPV-EIF---------YT---------------------------------PEPER--- 262
            .:.||...| |:|         ||                                 ||.:|   
Mouse   382 YIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQRA 446

  Fly   263 ----------------------------------------------------------------- 262
                                                                             
Mouse   447 VASVSEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILTEN 511

  Fly   263 ---DY------------------------------------------------------------ 264
               ||                                                            
Mouse   512 VSVDYRHSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLES 576

  Fly   265 ----------------------LEAAIRTVIQ-----------------------IHMCEEIEGD 284
                                  |.|..|.:::                       .|.|:  .|.
Mouse   577 YSASLEFGNLDESSLVQTNGNDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCD--AGA 639

  Fly   285 ILMFLTGQEEIEEACKRI----KREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGA 345
            ||:||.|.:||.....||    ||..||    ....:...|:|.:..:.|:::.: .||...   
Mouse   640 ILIFLPGYDEIVGLRDRILFDDKRFADN----THRYQVFMLHSNMQTSDQKKVLK-NPPAGV--- 696

  Fly   346 IGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTR 410
              ||:::||||||||:|::.||||||.|..|:|.::....|..|.:..||||||.||.|||||.|
Mouse   697 --RKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCR 759

  Fly   411 PGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFM----DPPAPETLMR 471
            ||.||||::...|:|.::..| ||:||..|..:.|..|.|...:....||:    :||....:..
Mouse   760 PGICFRLFSRLRFQNMLEFQT-PELLRMPLQELCLHTKLLAPVNCTIADFLMKAPEPPPALIVRN 823

  Fly   472 ALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFVRP 536
            |:::|..:.|:|...:||:||..:::.|::|.|.||::.:....|.:.||:|...|:....||.|
Mouse   824 AVQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLP 888

  Fly   537 NEA--KKAADEAKMRF-AHIDGDHLTLLNVYHAFKQSSEDPNW----CYENFINFRSLKSADNVR 594
            .:|  |:||...:.|| |....||:.||..:.|::::..| .|    |.:||::..:::....:|
Mouse   889 TQASQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQKARSD-GWERAFCEKNFLSQATMEIIIGMR 952

  Fly   595 QQL---------ARIMDRFNLRRTSTEFTSKDYYVNIRKALVQGFFMQVAHLERTGYYLTIKDNQ 650
            .||         .|.....::|..:|  .|:::.| ::.|||.|.:..:.|::|....||....:
Mouse   953 TQLLGQLRASGFVRARGGGDIRDVNT--NSENWAV-VKAALVAGMYPNLVHVDRENVILTGPKEK 1014

  Fly   651 NVQLHPSTCLDH-------------------KPDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLA 695
            .|:.||::.|..                   ..||:||:|  :|..:.|..:.       ||.|
Mouse  1015 KVRFHPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDE--MTRAHRIANIR-------CCSA 1069

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dhx15NP_610269.1 HrpA 71..>691 CDD:441249 230/883 (26%)
Ythdc2NP_001156485.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..50
R3H_DEXH_helicase 61..119 CDD:100077
PRK11131 203..>1033 CDD:182986 224/846 (26%)
DEXHc_YTHDC2 208..383 CDD:350745 72/174 (41%)
DEAH box 331..334 2/2 (100%)
ANK repeat 520..552 CDD:293786 0/31 (0%)
ANK 1 521..553 0/31 (0%)
ANK 2 554..586 0/31 (0%)
ANK repeat 554..582 CDD:293786 0/27 (0%)
SF2_C_RHA 612..767 CDD:350178 62/166 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1179..1303
YTH 1304..1433 CDD:410979
Blue background indicates that the domain is not in the aligned region.

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