DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and DHX30

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_011531792.1	Gene:	DHX30 / 22907	HGNCID:	16716	Length:	1265	Species:	Homo sapiens

Alignment Length:	726	Identity:	215/726 - (29%)
Similarity:	356/726 - (49%)	Gaps:	106/726 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PTMNPLTNTPY-----------SQRYQNLYKKR-------IALPVFEYQADFMRLLSLHQCIVLV 94
            |..:|:|..||           ||....|:::|       ..|||..::...:..:..|..:|:.
Human   463 PLSDPITGKPYVPLLEAEEVRLSQSLLELWRRRGPVWQEAPQLPVDPHRDTILNAIEQHPVVVIS 527

  Fly    95 GETGSGKTTQIPQWCVDFAVSKGRKGVSC----TQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIR 155
            |:||.||||:|||..::..|::|| |..|    |||||::|:|||||||.|:...|...||:.:|
Human   528 GDTGCGKTTRIPQLLLERYVTEGR-GARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVR 591

  Fly   156 FEDCSTAK-TLLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDL 219
            .|....:: ..|.:.|.|:|||:..|:|.|:....:::||.|||.:.||.|:.:||.:.|....|
Human   592 LESKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPAL 656

  Fly   220 KLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVEIFYTPE-----PERDYL----------EAAI 269
            :||:||||.|..:|.:||...|::||||..:||:..|..:     .:..||          |.|:
Human   657 RLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDILAKLGKHQYLHRHRHHESEDECAL 721

  Fly   270 R----TVIQIHMCEEIE-GDILMFLTGQEEIEEACKRIKREIDNLGSEIGELKCIPLYSTLPPNL 329
            .    |.:.:|:....| |.||.||.|.:||:...:|::   :.||....:...:|::|.:|...
Human   722 DLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRLQ---EALGMHESKYLILPVHSNIPMMD 783

  Fly   330 QQRIFEPAPPPNANGAIG-RKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSP 393
            |:.||:..|       :| ||:|::|||||||:||:.:|.|:|.|..|::.|:.:.:|..|....
Human   784 QKAIFQQPP-------VGVRKIVLATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCLETVW 841

  Fly   394 ISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHF 458
            :|:|:..||.|||||.:.|..:.|:.....: :|.....|||||:.|..:||| .|:.:.:....
Human   842 VSRANVIQRRGRAGRCQSGFAYHLFPRSRLE-KMVPFQVPEILRTPLENLVLQ-AKIHMPEKTAV 904

  Fly   459 DFM----DPPAPETLMRALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNE 519
            :|:    |.|..:.:..|:.||..:..||....||.||..::....||:|||.::.:....|.:.
Human   905 EFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHP 969

  Fly   520 ILSITAMLSVPQCFVRPNEAKKAADEAKMRFAHIDG-DHLTLLNVYHAFKQ------SSEDPNWC 577
            :|.:.:.|: ...|....:.:...|:.|...:|..| |||..:.....:::      .|...|:.
Human   970 LLVVVSCLT-RDPFSSSLQNRAEVDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRSSRENYL 1033

  Fly   578 YENFINFRSLKSADNVRQQLA-RIMDRFNLRRTS---------TEFTSKDYYVNIRKALVQGFF- 631
            .||.:...||:....:.:|.: .|.:.|.:.:.|         .|::.::..|  :..|:.|.:
Human  1034 EENLLYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLASAQCNEYSEEEELV--KGVLMAGLYP 1096

  Fly   632 --MQV--AHLERTGYYLTIKDNQ--------NVQLHPST----CLDHKPDWVIYNEFVLTTKN-- 678
              :||  ..:.|.|.:   |.|.        |:.||.||    ....:..|:.|  |:....|
Human  1097 NLIQVRQGKVTRQGKF---KPNSVTYRTKSGNILLHKSTINREATRLRSRWLTY--FMAVKSNGS 1156

  Fly   679 -YIRTVTDVKP 688
             ::|..:.|.|
Human  1157 VFVRDSSQVHP 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	17/69 (25%)
		DEXDc	67..255	CDD:214692	78/199 (39%)
		DEXDc	91..228	CDD:238005	61/141 (43%)
		HELICc	315..408	CDD:197757	35/93 (38%)
		HA2	478..561	CDD:214852	22/83 (27%)
		OB_NTP_bind	595..698	CDD:285018	26/124 (21%)
DHX30	XP_011531792.1	HrpA	494..>1143	CDD:224557	200/667 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810