DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and Dhx29

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_766182.2	Gene:	Dhx29 / 218629	MGIID:	2145374	Length:	1365	Species:	Mus musculus

Alignment Length:	795	Identity:	235/795 - (29%)
Similarity:	381/795 - (47%)	Gaps:	147/795 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KDPEASSSSAAAAAGTVAQILGGFVPNKQPPTMNPLTNTPYSQRYQNLYKKRIALPVFEYQADFM 82
            :|||.|..:..:.....|..|.........|..:.......:.:||.|.|:|..||||:::...:
Mouse   517 EDPEESWENLVSDEDLAALSLEPTSAEDLAPVRSLFRRLQSTPKYQRLLKERQQLPVFKHRDSIV 581

  Fly    83 RLLSLHQCIVLVGETGSGKTTQIPQWCV-DFAVSK--GRK-GVSCTQPRRVAAMSVAQRVSEEMD 143
            ..|..|:.:|:.|||||||:||:|.:.: |..:.:  .|| .:.||||||::|:|:|.||.||:.
Mouse   582 ETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLDECGARKCNIVCTQPRRISAVSLATRVCEELG 646

  Fly   144 VKLG-----EEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATD 203
            .:.|     ...||.||.|..::..|.|.|.|.|:|||:...|.:|.....:::||.|||::.:|
Mouse   647 CESGPGGRNSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSD 711

  Fly   204 ILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVEIFY------------ 256
            .|:.:|||::::||||.|::||||:|:.||..||.:.|::::.||::|||:|:
Mouse   712 FLLVILKEILQKRSDLHLILMSATVDSDKFSTYFTHCPILRISGRSYPVEVFHLEDIVEETGFVL 776

  Fly   257 -----------------------------------------TPE--------------------P 260
                                                     :||                    |
Mouse   777 EKDSEYCQKFLEEEEEITINVTSKAGGVKKYQEYIPVQSGASPELNPFYQKYSSRTQHAILYMNP 841

  Fly   261 ERDYLEAAIRTVIQIHMCEE---IEGDILMFLTGQEEIEEACKRIKREIDNLGSE----IGELKC 318
            .:..|:..:..::.:....:   |||.:|:||.|...|::.       .|.|.|:    ....:.
Mouse   842 HKINLDLILELLVYLDKSPQFRNIEGAVLIFLPGLAHIQQL-------YDLLSSDRRFYSERYQV 899

  Fly   319 IPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPR 383
            |.|:|.|....|...| ..|||..     ||:|::||||||.:||..||||||.|..|:..|:..
Mouse   900 IALHSVLSTQDQAAAF-MFPPPGV-----RKIVLATNIAETGITIPDVVFVIDTGRTKENKYHES 958

  Fly   384 IRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLK 448
            .::.||:.:.:|||||.||.|||||.|.|.||||||.:.|:..: |.:.|||||..|..:.|.:.
Mouse   959 SQMSSLVETFVSKASALQRQGRAGRVRDGFCFRLYTRERFEGFL-DYSVPEILRVPLEELCLHIM 1022

  Fly   449 K--LGIDDLVHFDF----MDPPAPETLMRALELLNYLAALD-DDGNLTDLGAVMSEFPLDPQLAK 506
            |  ||..:    ||    :|||..:.:..|:.||..:.|.: ::..||.||..::..|::.::.|
Mouse  1023 KCDLGSPE----DFLSKALDPPQLQVISNAMNLLRKIGACEPNEPKLTPLGQHLAALPVNVKIGK 1083

  Fly   507 MLIASCQHNCSNEILSITAMLSVPQCFVRPNEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQSS 571
            |||......|...:.::.|:::....|:.|...|..||.||...|..|.||||:.|.|..:|::.
Mouse  1084 MLIFGAIFGCLEPVATLAAVMTEKSPFITPIGRKDEADLAKSSLAVADSDHLTIYNAYLGWKKAQ 1148

  Fly   572 EDP------NWCYENFINFRSLKSADNVRQQLARIMDRFNL--------RRTSTEFTSKDYYVNI 622
            ::.      ::|..||:|..||.:.::|:|:|.:::.....        |:.....:.:|..: :
Mouse  1149 QEGGFRSEISYCQRNFLNRTSLLTLEDVKQELMKLVKAAGFSSSPSWEGRKGPQTLSFQDIAL-L 1212

  Fly   623 RKALVQGFFMQVAHL---------ERTGYYLTIKDNQNVQLHPSTCLDHKPD-----WVIYNEFV 673
            :..|..|.:..|..:         |:....:.....: .|:|||:.   ..|     |::|.|.|
Mouse  1213 KAVLAAGLYDSVGKIMCTKSVDVTEKLACMVETAQGK-AQVHPSSV---NRDLQTYGWLLYQEKV 1273

  Fly   674 LTTKNYIRTVTDVKP 688
            ..|:.|:|..|.:.|
Mouse  1274 RYTRVYLRETTLITP 1288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	18/51 (35%)
		DEXDc	67..255	CDD:214692	81/196 (41%)
		DEXDc	91..228	CDD:238005	61/145 (42%)
		HELICc	315..408	CDD:197757	41/92 (45%)
		HA2	478..561	CDD:214852	25/83 (30%)
		OB_NTP_bind	595..698	CDD:285018	22/116 (19%)
Dhx29	NP_766182.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..74
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..222
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..257
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..524		4/6 (67%)
		DEXDc	577..763	CDD:214692	75/185 (41%)
		DEXDc	588..735	CDD:238005	60/146 (41%)
		DEAH box. /evidence=ECO:0000255\|HAMAP-Rule:MF_03068	701..704		2/2 (100%)
		Helicase_C	863..984	CDD:278689	53/133 (40%)
		HA2	1055..1136	CDD:214852	23/80 (29%)
		OB_NTP_bind	1178..1298	CDD:285018	22/116 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810