Protein Alignment Dhx15 and smgl-2

DIOPT Version :10

• Sequence 1: NP_610269.1
• Gene: Dhx15 / 35654
• FlyBaseID: FBgn0033160
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001294374.1
• Gene: smgl-2 / 177135
• WormBaseID: WBGene00021365
• Length: 1089
• Species: Caenorhabditis elegans
• Alignment Length: 589
• Identity: 207/589 - (35%)
• Similarity: 327/589 - (55%)
• Gaps: 55/589 - (9%)

  Fly    60 QRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSKGRKGVSCT 124
            |:.|.|.|.:..||:.|...:.:.||..:|.:::.|:||.||:||:||    :.:..|..||:||
 Worm   132 QKLQKLRKLQKELPIAERAGEIVELLKTNQVLIVAGDTGCGKSTQVPQ----YLLKAGFTGVACT 192

  Fly   125 QPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQV 189
            ||||:|..::|:||:.|...:.|.||.:.||||...:.||.|.::|:|:|||:...|.:|::|.|
 Worm   193 QPRRIACTALARRVAYETLNQYGSEVAFQIRFETTKSQKTKLLFLTEGLLLRQMEKDSLLEKYNV 257

  Fly   190 ILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVEI 254
            |:|||.|||.|.:|:|:|:|:::..:|.||||::||||::...|:.||:.||:::||||..|:::
 Worm   258 IILDEVHERHLTSDLLIGLLRDLCTKRDDLKLILMSATINLDLFKGYFEGAPVVQVPGRLFPIDV 322

  Fly   255 FYTP---------------EPERDYLEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRIKR 304
            .:.|               :|| .||:  |..:|.........||.|:||.|..||....:.:|.
 Worm   323 RWHPIKQFIDQSDKKTHKIDPE-PYLK--ILELIDKQFPSTQRGDALIFLNGVAEISMVAEHLKN 384

  Fly   305 --EIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIG-RKVVVSTNIAETSLTIDGV 366
              |:.|     |.: .:.|:|||....|.::|:.||       :| ||.::|||:||||:||||:
 Worm   385 YAELTN-----GWI-ILMLHSTLSVEEQDKVFDQAP-------VGIRKCILSTNVAETSVTIDGI 436

  Fly   367 VFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNT 431
            .||||.|......:.|....:.|....:|||||.||.||||||.||.|:|||:::.|: :|.|.|
 Worm   437 RFVIDSGKVNLIKHEPGTGTQKLTEFWVSKASANQRKGRAGRTGPGICYRLYSQEQFE-KMDDFT 500

  Fly   432 YPEILRSNLGTVVLQL--KKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALDDDG----NLTD 490
            ..||.|.:|..:.|::  ..||:|... |.|::.|:.:.|...||:|.:...|..|.    .||.
 Worm   501 VSEINRVSLQEMALKMISLNLGLDPRT-FPFIEKPSEDVLNEGLEVLKFQRVLRSDRGDILTLTA 564

  Fly   491 LGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFVRPNEAKKAADEAKMRFAHIDG 555
            ||.::|:.|::..:||||:..|..:....:|::.|.|||...|...:..:....|.:.......|
 Worm   565 LGNMVSKLPVEVPIAKMLVYGCVVDELEVMLTVAAGLSVQSPFTNRSYRELEIVERRASLTSPLG 629

  Fly   556 DHLTLLNVYH------AFKQSSEDPNWCYENFINFRSLKSADNVRQQLARIMDRFNL-RRTSTEF 613
            |..||::::.      ||:.::.  .|..||.|:...|.....:|.|..:|::...| .:.|...
 Worm   630 DPFTLISIFREWVLQKAFEGTAR--RWTMENGIDEHRLYEISKLRAQYRQILEDAGLVEKASAAE 692

  Fly   614 TSKD 617
            |.:|
 Worm   693 TGED 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_610269.1	HrpA	71..>691	CDD:441249	203/578 (35%)
smgl-2	NP_001294374.1	HrpA	143..>694	CDD:441249	201/574 (35%)
		OB_NTP_bind	788..888	CDD:400182