DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and rha-2

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_498895.1	Gene:	rha-2 / 176207	WormBaseID:	WBGene00015525	Length:	1148	Species:	Caenorhabditis elegans

Alignment Length:	838	Identity:	246/838 - (29%)
Similarity:	378/838 - (45%)	Gaps:	180/838 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KKDPEASSSSAAAAAGTVAQILGGFVPNKQPPTMNPLTNTPYSQRYQNLYKKRIALPVFEYQADF 81
            ::|.|.|.:....|..|...|      |::...:         :|.:.:.|.|..||:|..:...
Worm   196 REDDEESDNEDILALPTTTVI------NRKKVIV---------ERSKEIQKSRAELPIFAEEMRI 245

  Fly    82 MRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSKGRKGVSCTQPRRVAAMSVAQRVSEEMDVKL 146
            :..::.:...|:.|||||||||||||:..:...:...:.:..|:||||||:::||||..|:  ..
Worm   246 VEAINENLVTVVCGETGSGKTTQIPQFLYEAGYASEGELIGITEPRRVAAIAMAQRVGVEL--AK 308

  Fly   147 GEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVLKE 211
            .:||.|.||:|...:..|.:.:||||:|::|...|.||.:|.|||:||||||::.:|:|:|:|..
Worm   309 PDEVSYQIRYEGTRSETTNILFMTDGVLMKEMEQDVMLKKYSVILIDEAHERSMYSDVLIGMLSR 373

  Fly   212 VIRQRS----DLKLVVMSATLDAGKF--QQYFDNAPLM-----KVPGRTHPVEIFYTPEPERDYL 265
            ::..||    .|:||:|||||....|  ::.|   ||:     ||..|..||.:.:......||:
Worm   374 IVPLRSKTARPLRLVIMSATLRLDDFTHKKLF---PLLTPKVIKVDARQFPVSVHFEKRTPDDYI 435

  Fly   266 EAAIRTVIQIHMCEEI-EGDILMFLTGQEEIE--------------------------------- 296
            .:|.|...:||  |.: .|.||:|:|||.|::
Worm   436 ASAFRKTCRIH--ETLPPGAILVFVTGQHEVKQLITKLKKRYPVVYETDKNGEVLVKGTKEWKEK 498

  Fly   297 --EACKRIKRE---------------IDNL--GSEIGE--------------------------- 315
              ||.|.||.|               .|.|  |.::.|
Worm   499 KVEAAKSIKLEDFKEETPETEDFEDVDDGLMDGDDMNERGAAEAFDDYEEFENGDGDLSDGKVEN 563

  Fly   316 -----------LKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFV 369
                       |.|:||||.|....|:|:|:..|      |..|..|:|||:|||||||.||.:|
Worm   564 SIGAPPADCEPLYCLPLYSLLSMGKQRRVFDETP------AGMRLCVISTNVAETSLTIPGVKYV 622

  Fly   370 IDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKN--EMQDNTY 432
            ||.||.|:::|:....|....|..||:||..||:|||||...|..:|||:...:::  :..|
Worm   623 IDGGFEKRRLYDSITGVSRFAVCRISQASGDQRAGRAGRISAGHAYRLYSSAVYQDFVKFAD--- 684

  Fly   433 PEILRSNLGTVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALDD-------DGNLTD 490
            ||||......:||.||.:.|..:|:|.|...|..:.|..|.:.|..|.||.:       :..:|.
Worm   685 PEILSKPADQLVLHLKSMNIVKVVNFPFPSAPDEQMLESAEKRLCRLGALSESTKNGKTEARITK 749

  Fly   491 LGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFV--------RPNEAKK----AA 543
            ||..::.|||.|..||.:..:.|||..:..:.:.::|||.:..:        .|.|.|:    ..
Worm   750 LGKTLAVFPLAPSYAKFIAMADQHNLMSHAILLISLLSVREPLIPVSSLRGDTPEETKELMKNVL 814

  Fly   544 DEAKMRFAHID----GDHLTLLNVYHAFKQSSEDPNWCYENFINFRSLKSADNVRQQLARIMDRF 604
            .|.:...:|..    ||...|::.....:|...:...|.:..:..::|..|..:||||..|::..
Worm   815 KERRRWCSHTGARRLGDLKVLMHAASVAEQIKYNARECEKVGLRVKALVEARKLRQQLTNIVNAS 879

  Fly   605 NLRRTSTEFTS-----KDYYVN-IRKALVQGFFMQVA-HLERT--------GYYLTIKDNQNVQL 654
            ..:..:....|     .|.... :|:.:|..|..::| .::|:        |.|.|.....:|.:
Worm   880 CKKEHAAALDSDLPPPTDQQAQLLRQMVVASFSDRLARRVDRSVGQEEVQKGAYETTLIKGHVFI 944

  Fly   655 HP-STCLDHKPDWVIYNEFV-LTTKNYIRTVTDVKPEWLCCLAPQY-----YDLNNFP 705
            .| |.....:|::|||.|.| :..|..:.:|..|..|||..||..|     .|.|..|
Worm   945 DPCSVVFTEEPEFVIYQELVQVNEKKLMTSVCAVDKEWLSRLAESYCNYGEQDKNQEP 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	13/51 (25%)
		DEXDc	67..255	CDD:214692	80/198 (40%)
		DEXDc	91..228	CDD:238005	64/140 (46%)
		HELICc	315..408	CDD:197757	45/130 (35%)
		HA2	478..561	CDD:214852	25/105 (24%)
		OB_NTP_bind	595..698	CDD:285018	31/119 (26%)
rha-2	NP_498895.1	HrpA	218..989	CDD:224557	235/795 (30%)
		DEXDc	254..394	CDD:238005	64/141 (45%)
		P-loop_NTPase	<350..>477	CDD:304359	47/131 (36%)
		HELICc	577..662	CDD:197757	44/90 (49%)
		HA2	730..822	CDD:214852	22/91 (24%)
		OB_NTP_bind	870..990	CDD:285018	31/119 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820