DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhx15 and ddx-35

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_497420.1	Gene:	ddx-35 / 175308	WormBaseID:	WBGene00022056	Length:	732	Species:	Caenorhabditis elegans

Alignment Length:	709	Identity:	284/709 - (40%)
Similarity:	430/709 - (60%)	Gaps:	51/709 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EASSSSAAAAAGTVAQILGGFVPNKQPPTMNPLT--NTPYSQRYQNLYKKRIALPVFEYQADFMR 83
            |.|:.:|.||                ||....|.  |.||:.  .|:.::||.||:|:.:...:.
Worm    42 ERSTENAGAA----------------PPIEEQLKVHNNPYAS--LNIQQQRIRLPIFKNRGHILY 88

  Fly    84 LLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSKGRKGVSCTQPRRVAAMSVAQRVSEEMDVKLGE 148
            :...::.|::|||||.||:||:||:.::...:...:.:..|||||||.:::|.||:||.|..||.
Worm    89 MCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGRQIVITQPRRVAVVTLATRVAEEKDCILGH 153

  Fly   149 EVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVI 213
            :|||::||:|.|...|.:|:||||:||||.::||:|.:|.:|::||||||:..||||:|:|:::|
Worm   154 DVGYTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKII 218

  Fly   214 RQRSDLKLVVMSATLDAGKFQQYF----------DNAPLMKVPGRTHPVEIFYTPEPERDYLEAA 268
            :.|:||:::|.||||||..|:.:|          |.|.::.|.||||||.:.:|.....||.::|
Worm   219 QIRNDLRIIVSSATLDAELFKDFFEMNETGNSDKDTAGIISVEGRTHPVAVHHTKTSVPDYCQSA 283

  Fly   269 IRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRIKREIDNLGSEIGELKCIPLYSTLPPNLQQRI 333
            :.|||.||. .|..||||:|||||:|:|:.|::::....|| .....|..:|.|..||...|.:.
Worm   284 VDTVINIHK-HENPGDILVFLTGQDEVEDVCEKLRELAGNL-KNCDRLWVVPCYGALPAREQMKA 346

  Fly   334 FEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKAS 398
            |:..|    :|.  |||||:|||||.|:||.|:.:|||.|:.|.:..:....||:|:...:||||
Worm   347 FDSTP----HGT--RKVVVATNIAEASITIPGICYVIDTGYVKLRAQHAANGVETLMRVTVSKAS 405

  Fly   399 AQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFMDP 463
            |:||:|||||.|||||:|||.|..|: ...:.|.|||.|..:.:.:||||.||:.::..|.::.|
Worm   406 AEQRAGRAGRIRPGKCYRLYPESEFE-RFAEGTVPEIQRCQMASTILQLKALGVQNVHRFHYLSP 469

  Fly   464 PAPETLMRALELLNYLAALDDDGNLTD-LGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAML 527
            |....::..||||..|.|:|:...||. ||..|:||||.|..:|.|:.|.:..||.|:::|.||:
Worm   470 PPSWAMINGLELLYALGAIDETSQLTSPLGLQMAEFPLPPMHSKCLLKSAEFGCSTEMVTIVAMM 534

  Fly   528 SVPQCFVRPNEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQSSEDPNWCYENFINFRSLKSADN 592
            .:...|:.|...:..||..:.:||..:|||:|:|||:..|.::.....||.::|:|:|.|..|||
Worm   535 QIQDVFITPYRQRHQADVIRKKFAVEEGDHMTMLNVFTKFVENGRSKKWCSDHFVNYRGLMRADN 599

  Fly   593 VRQQLARIMDRFNLRRTSTE--FTSKDYYVNIRKALVQGFFMQVAHLERTGYYLTIKDNQNVQLH 655
            ||.||.|::.||.:.:.|:.  ....:   |||:.||.|||.|.|....||.|:|:|::....::
Worm   600 VRSQLVRLLKRFEIEKVSSRGLINCSE---NIRQCLVTGFFSQAAQYHYTGKYMTVKESFPFNMY 661

  Fly   656 PSTCLDHK---PDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLAPQYYDLNNFPQCEAKR 711
            ..:.:..|   |.|||:.|.:   ::.||.||.::||||..|||.||:.....:...||
Worm   662 KGSSIMFKKDYPKWVIFTEVM---QDSIRDVTVIEPEWLYELAPHYYEFGTEGELAEKR 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	17/53 (32%)
		DEXDc	67..255	CDD:214692	88/197 (45%)
		DEXDc	91..228	CDD:238005	68/136 (50%)
		HELICc	315..408	CDD:197757	41/92 (45%)
		HA2	478..561	CDD:214852	32/83 (39%)
		OB_NTP_bind	595..698	CDD:285018	38/107 (36%)
ddx-35	NP_497420.1	HrpA	70..702	CDD:224557	266/646 (41%)
		DEXDc	96..233	CDD:238005	68/136 (50%)
		Helicase_C	284..416	CDD:278689	62/139 (45%)
		HA2	484..568	CDD:214852	32/83 (39%)
		OB_NTP_bind	602..704	CDD:285018	38/107 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730