DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and DHX36

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_065916.2	Gene:	DHX36 / 170506	HGNCID:	14410	Length:	1008	Species:	Homo sapiens

Alignment Length:	787	Identity:	239/787 - (30%)
Similarity:	384/787 - (48%)	Gaps:	144/787 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 RYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSKGRKG----V 121
            ||..:...|..||.:..|.:.:.|:..||..|:.||||.|||||:.|:.:|..:.:| ||    :
Human   196 RYIEMQHFREKLPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERG-KGSACRI 259

  Fly   122 SCTQPRRVAAMSVAQRVSEEM--DVKLGEEVGYSIRFEDCSTAKT-LLKYMTDGMLLREAMSDPM 183
            .||||||::|:|||:||:.|.  ....|...||.||.:.....|. .:.|.|.|::|:...|||.
Human   260 VCTQPRRISAISVAERVAAERAESCGSGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDPY 324

  Fly   184 LDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPGR 248
            |.....|:|||.|||.|.:|:||.|:|:::..|||||:::|||||:|.||.:||.|.|::.:||.
Human   325 LSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGF 389

  Fly   249 THPV----------EIFYTPEPER-------------------------------DYLEAAIR-- 270
            |.||          :|.|.||.:.                               ||:....|
Human   390 TFPVVEYLLEDVIEKIRYVPEQKEHRSQFKRGFMQGHVNRQEKEEKEAIYKERWPDYVRELRRRY 454

  Fly   271 ---TVIQIHM-------------------CEEIEGDILMFLTGQEEIEEACKRIKREIDNLGSEI 313
               ||..|.|                   .||.:|.||:||.|.:.|...       .|.|.|::
Human   455 SASTVDVIEMMEDDKVDLNLIVALIRYIVLEEEDGAILVFLPGWDNISTL-------HDLLMSQV 512

  Fly   314 ----GELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGF 374
                .:...|||:|.:|...|.::|:..||    |.  ||:|::|||||||:|||.||:|||.|.
Human   513 MFKSDKFLIIPLHSLMPTVNQTQVFKRTPP----GV--RKIVIATNIAETSITIDDVVYVIDGGK 571

  Fly   375 AKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSN 439
            .|:..::.:..:.::....:|||:|:||.|||||.:||.|:.||.... .:.:.|...|||||:.
Human   572 IKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLR-ASLLDDYQLPEILRTP 635

  Fly   440 LGTVVLQLKKLGIDDLVHF--DFMDPPAPETLMRALELLNYLAALDDDGNLTDLGAVMSEFPLDP 502
            |..:.||:|.|.:..:.:|  ..||||:.|.::.::..|..|.|||....||.||..::..|::|
Human   636 LEELCLQIKILRLGGIAYFLSRLMDPPSNEAVLLSIRHLMELNALDKQEELTPLGVHLARLPVEP 700

  Fly   503 QLAKMLIASCQHNCSNEILSITAMLSVPQCFVRPNEAKKAADEAKMRFA-HIDGDHLTLLNVYHA 566
            .:.||::......|.:.:|:|.|.||....||.|...:|.||..:...| ....||||::|.:..
Human   701 HIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKELAKDTRSDHLTVVNAFEG 765

  Fly   567 FKQSSE-----DPNWCYENFINFRSLKSADNVRQQLAR------IMDRFNLRRTSTEFTSKDYYV 620
            ::::..     :.::|:|.|::..:|:...|::.|.|.      .:...|.:...:...|.:..:
Human   766 WEEARRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRNPKDPESNINSDNEKI 830

  Fly   621 NIRKALVQGFFMQVAHL------ERTGYYLTIKDNQNVQLHPSTC----LDHKPDWVIYNEFVLT 675
             |:..:..|.:.:||.:      :|....:..|.:..|.:||.:.    .|...:|:||:..:.|
Human   831 -IKAVICAGLYPKVAKIRLNLGKKRKMVKVYTKTDGLVAVHPKSVNVEQTDFHYNWLIYHLKMRT 894

  Fly   676 TKNYIRTVTDVKP------------------------EWLCCLAPQYYDLNNFPQCEAKRQLE-L 715
            :..|:...|:|.|                        ||:...:|.  .:.:..: |.:::|: |
Human   895 SSIYLYDCTEVSPYCLLFFGGDISIQKDNDQETIAVDEWIVFQSPA--RIAHLVK-ELRKELDIL 956

  Fly   716 LQQRLET 722
            ||:::|:
Human   957 LQEKIES 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	15/40 (38%)
		DEXDc	67..255	CDD:214692	84/204 (41%)
		DEXDc	91..228	CDD:238005	63/143 (44%)
		HELICc	315..408	CDD:197757	39/92 (42%)
		HA2	478..561	CDD:214852	29/83 (35%)
		OB_NTP_bind	595..698	CDD:285018	25/142 (18%)
DHX36	NP_065916.2	Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000269\|PubMed:18279852	1..200		2/3 (67%)
		Required for the pre-miR-134 transport. /evidence=ECO:0000250\|UniProtKB:D4A2Z8	1..104
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000269\|PubMed:18854321	1..51
		Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000269\|PubMed:21149580, ECO:0000269\|PubMed:21846770, ECO:0000269\|PubMed:24151078	53..105
		DSM (DHX36-specific motif). /evidence=ECO:0000269\|PubMed:20472641, ECO:0000269\|PubMed:22238380, ECO:0000269\|PubMed:24369427, ECO:0000269\|PubMed:26195789, ECO:0000269\|PubMed:26649896	53..75
		RecA-like domain 1. /evidence=ECO:0000250\|UniProtKB:Q05B79	106..386		81/190 (43%)
		DEXDc	210..392	CDD:214692	79/182 (43%)
		DEXDc	224..369	CDD:238005	64/145 (44%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	265..317		18/51 (35%)
		DEAH box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	334..337		2/2 (100%)
		RecA-like domain 2. /evidence=ECO:0000250\|UniProtKB:Q05B79	387..628		75/254 (30%)
		Helicase_C	476..606	CDD:278689	52/142 (37%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	498..557		22/71 (31%)
		Nuclear localization signal. /evidence=ECO:0000303\|PubMed:14731398	517..528		4/10 (40%)
		WH domain. /evidence=ECO:0000250\|UniProtKB:Q05B79	629..698		25/68 (37%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	638..697		19/58 (33%)
		HA2	676..760	CDD:214852	29/83 (35%)
		OB_NTP_bind	800..917	CDD:285018	22/117 (19%)
		OB-fold-like subdomains. /evidence=ECO:0000250\|UniProtKB:Q05B79	841..905		14/63 (22%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	849..860		1/10 (10%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	870..900		8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820