DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dhx15 and DHX9

DIOPT Version :10

Sequence 1:NP_610269.1 Gene:Dhx15 / 35654 FlyBaseID:FBgn0033160 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001348.2 Gene:DHX9 / 1660 HGNCID:2750 Length:1270 Species:Homo sapiens


Alignment Length:800 Identity:213/800 - (26%)
Similarity:374/800 - (46%) Gaps:153/800 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 PEASSSSAAAAAGTVAQILGGFVPNKQ----------PP--TMNPLTN-----------TP---- 57
            ||..|...|...|.:||    |.|:::          ||  ..||.|:           ||    
Human   301 PEDPSVPVALNIGKLAQ----FEPSQRQNQVGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQIS 361

  Fly    58 ------------YSQRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCV 110
                        .....|.:.::|..|||.:::::.:..:|.:..:::.|.||.|||||:||:.:
Human   362 MDLKNELMYQLEQDHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFIL 426

  Fly   111 DFAVSKGRK---GVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFED-CSTAKTLLKYMTD 171
            |..:...|.   .:..|||||::|:|||:||:.|...:.|:..|||:|||. .......:.:.|.
Human   427 DDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEPGKSCGYSVRFESILPRPHASIMFCTV 491

  Fly   172 GMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQY 236
            |:|||:.  :..:.....:::||.|||.:.||.|:.||::|::...::::|:||||:|...|.:|
Human   492 GVLLRKL--EAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPEVRIVLMSATIDTSMFCEY 554

  Fly   237 FDNAPLMKVPGRTHPVEIF----------YTPEPER----------------------------- 262
            |.|.|:::|.|||:||:.:          :.|.|:.                             
Human   555 FFNCPIIEVYGRTYPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDDGGEDDDANCNLICGDEYGPE 619

  Fly   263 ---------------DYLEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRIKREIDNLGSE 312
                           :.:||.::.:..::    :.|.:|:||.|...|....|.::.. .:.||.
Human   620 TRLSMSQLNEKETPFELIEALLKYIETLN----VPGAVLVFLPGWNLIYTMQKHLEMN-PHFGSH 679

  Fly   313 IGELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIG-RKVVVSTNIAETSLTIDGVVFVIDPGFAK 376
              ..:.:||:|.:|...|:::|:|.|       :| .||::||||||||:||:.||:|||....|
Human   680 --RYQILPLHSQIPREEQRKVFDPVP-------VGVTKVILSTNIAETSITINDVVYVIDSCKQK 735

  Fly   377 QKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLG 441
            .|::.....:.:......||.:.:||.|||||.|||.||.|.:...|: .::.:..||:.|:.|.
Human   736 VKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFE-RLETHMTPEMFRTPLH 799

  Fly   442 TVVLQLKKLGIDDLVHF--DFMDPPAPETLMRALELLNYLAALDDDGNLTDLGAVMSEFPLDPQL 504
            .:.|.:|.|.:..:..|  ..::||..:.::.|...|..|.|||.:..||.||.::::.|::|:.
Human   800 EIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRF 864

  Fly   505 AKMLIASCQHNCSNEILSITAMLSVPQCFVRPNEAKKAA----DEAKMRFAHIDGDHLTLLNVYH 565
            .||:|..|.....:.|.:|.|....|:.|:  ||.|:..    :.|..||:    ||:.||:|:.
Human   865 GKMMIMGCIFYVGDAICTIAAATCFPEPFI--NEGKRLGYIHRNFAGNRFS----DHVALLSVFQ 923

  Fly   566 AF---KQSSEDP--NWCYENFINFRSLKSADNVRQQLARIM------DRFNLRRTSTEFTSKDYY 619
            |:   :...|:.  .:|....:|..:|:.....:.||..|:      :...|.:..|. |..|..
Human   924 AWDDARMGGEEAEIRFCEHKRLNMATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTN-TGPDNN 987

  Fly   620 VNIRKALVQ-GFFMQVAHLERTGYYLTIKDNQNVQLHPST--C------LDHKPDWVIYNEFVLT 675
            :::..:|:. |.:..|.:.:.....|| .:.:|..:|.|:  |      :.:...:.::.|.:.|
Human   988 LDVVISLLAFGVYPNVCYHKEKRKILT-TEGRNALIHKSSVNCPFSSQDMKYPSPFFVFGEKIRT 1051

  Fly   676 TKNYIRTVTDVKPEWLCCLA 695
            .....:.:|.|.|..|...|
Human  1052 RAISAKGMTLVTPLQLLLFA 1071

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dhx15NP_610269.1 HrpA 71..>691 CDD:441249 193/704 (27%)
DHX9NP_001348.2 Interaction with CREBBP. /evidence=ECO:0000269|PubMed:9323138 1..250
DSRM_DHX9_rpt1 3..71 CDD:380683
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYY 5..9
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYY 53..55
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 83..118
DSRM_DHX9_rpt2 178..252 CDD:380684
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYX 182..186
Interaction with BRCA1. /evidence=ECO:0000269|PubMed:9662397 230..325 9/27 (33%)
siRNA-binding. /evidence=ECO:0000305|PubMed:23361462 234..236
Necessary for interaction with RNA polymerase II holoenzyme. /evidence=ECO:0000269|PubMed:9323138 255..664 95/372 (26%)
Necessary for interaction with H2AX. /evidence=ECO:0000269|PubMed:15613478 313..952 186/665 (28%)
DEXHc_DHX9 330..563 CDD:350730 71/234 (30%)
MTAD. /evidence=ECO:0000269|PubMed:11416126 331..380 7/48 (15%)
HrpA 388..>886 CDD:441249 153/514 (30%)
Core helicase. /evidence=ECO:0000305|PubMed:25062910 398..809 128/427 (30%)
DEIH box 511..514 2/2 (100%)
Nuclear localization signal (NLS1). /evidence=ECO:0000255 586..595 2/8 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 588..608 1/19 (5%)
HA2. /evidence=ECO:0000269|PubMed:25062910 831..919 29/93 (31%)
OB-fold. /evidence=ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:25149208 958..1074 22/115 (19%)
OB_NTP_bind 994..1073 CDD:400182 15/78 (19%)
RGG. /evidence=ECO:0000269|PubMed:10207077, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:9111062 1150..1270
Nuclear localization signal (NLS2). /evidence=ECO:0000269|PubMed:16375861 1155..1173
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1229..1248
Blue background indicates that the domain is not in the aligned region.

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