DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and Dhx9

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_011246220.1	Gene:	Dhx9 / 13211	MGIID:	108177	Length:	1384	Species:	Mus musculus

Alignment Length:	717	Identity:	197/717 - (27%)
Similarity:	355/717 - (49%)	Gaps:	108/717 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 QNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSKGRK---GVSCT 124
            |::.::|..|||.:::|:.:..:|.:..:::.|.||.|||||:||:.:|..:...|.   .:..|
Mouse   382 QSVLQERELLPVKKFEAEILEAISSNSVVIIRGATGCGKTTQVPQYILDDFIQNDRAAECNIVVT 446

  Fly   125 QPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFED-CSTAKTLLKYMTDGMLLREAMSDPMLDQYQ 188
            ||||::|::||:||:.|...:.|:..|||:|||. .......:.:.|.|:|||:.  :..:....
Mouse   447 QPRRISAVAVAERVAYERGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKL--EAGIRGIS 509

  Fly   189 VILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVE 253
            .:::||.|||.:.||.|:.||::|:....::::|:||||:|...|.:||.|.|:::|.|||.||:
Mouse   510 HVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSATIDTTMFCEYFFNCPIIEVYGRTFPVQ 574

  Fly   254 IF------------------------------------------YTPEPER------------DY 264
            .:                                          |.||.:.            :.
Mouse   575 EYFLEDCIQMTQFIPPPKDKKKKDKEDDGGEDDDANCNLICGDEYGPETKLSMSQLNEKETPFEL 639

  Fly   265 LEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRIKREIDNLGSEIGELKCIPLYSTLPPNL 329
            :||.::.:..::    :.|.:|:||.|...|....|.::.. .:.||.  ..:.:||:|.:|...
Mouse   640 IEALLKYIETLN----VPGAVLVFLPGWNLIYTMQKHLENN-SHFGSH--RYQILPLHSQIPREE 697

  Fly   330 QQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPI 394
            |:::|:|.|    :|.  .||::||||||||:||:.||:|||....|.|::.....:.:......
Mouse   698 QRKVFDPVP----DGV--TKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWA 756

  Fly   395 SKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHF- 458
            ||.:.:||.|||||.|||.||.|.:...| :.::.:..||:.|:.|..:.|.:|.|.:..:..|
Mouse   757 SKTNLEQRKGRAGRVRPGFCFHLCSRARF-DRLETHMTPEMFRTPLHEIALSIKLLRLGGIGQFL 820

  Fly   459 -DFMDPPAPETLMRALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILS 522
             ..::||..:.::.|...|..|.|||.:..||.||.::::.|::|:..||:|..|.....:.:.:
Mouse   821 AKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAVCT 885

  Fly   523 ITAMLSVPQCFVRPNEAKKAA----DEAKMRFAHIDGDHLTLLNVYHAF---KQSSEDP--NWCY 578
            |:|....|:.|:  :|.|:..    :.|..||:    ||:.||:|:.|:   :.|.|:.  .:|.
Mouse   886 ISAATCFPEPFI--SEGKRLGYIHRNFAGNRFS----DHVALLSVFQAWDDARMSGEEAEIRFCE 944

  Fly   579 ENFINFRSLKSADNVRQQLARIM------DRFNLRRTSTEFTSKDYYVNIRKALVQ-GFFMQVAH 636
            :..:|..:|:.....:.||..|:      :...|.:..|. |..|..:::..:|:. |.:..|.:
Mouse   945 QKRLNMATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTN-TGPDNNLDVVISLLAFGVYPNVCY 1008

  Fly   637 LERTGYYLTIKDNQNVQLHPST--C------LDHKPDWVIYNEFVLTTKNYIRTVTDVKPEWLCC 693
            .:.....|| .:.:|..:|.|:  |      :.:...:.::.|.:.|.....:.:|.|.|..|..
Mouse  1009 HKEKRKILT-TEGRNALIHKSSVNCPFSSQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLLL 1072

  Fly   694 LA 695
            .|
Mouse  1073 FA 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	11/38 (29%)
		DEXDc	67..255	CDD:214692	69/191 (36%)
		DEXDc	91..228	CDD:238005	50/140 (36%)
		HELICc	315..408	CDD:197757	35/92 (38%)
		HA2	478..561	CDD:214852	25/86 (29%)
		OB_NTP_bind	595..698	CDD:285018	23/116 (20%)
Dhx9	XP_011246220.1	DSRM_DHX9_rpt1	3..71	CDD:380683
		DSRM_DHX9_rpt2	181..255	CDD:380684
		DEXHc_DHX9	333..566	CDD:350730	64/185 (35%)
		HrpA	337..>1055	CDD:224557	191/696 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810