DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and Dhx32

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001272959.1	Gene:	Dhx32 / 101437	MGIID:	2141813	Length:	751	Species:	Mus musculus

Alignment Length:	751	Identity:	295/751 - (39%)
Similarity:	457/751 - (60%)	Gaps:	43/751 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKRRIEVGE------TYGSKAKKDPEASSSSAAAAAGTVAQILGGFVPNKQPPTMNPLTNTPYS 59
            ||..|.|:.|      ....:.:..||:..||.....|.:|         .:...:||....|||
Mouse     1 MSSLREEMDEEELDHPNASPEKRYFPESLDSSDGDEEGVLA---------CEDLELNPFDGLPYS 56

  Fly    60 QRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVS--KGRKGVS 122
            .||..|.|:|..||:::.:..||..|..:|.:|:.|::..||::|:||||.::.:|  ....||.
Mouse    57 SRYYKLLKEREELPIWKEKYSFMESLLQNQVVVVSGDSKCGKSSQVPQWCAEYCLSIHYQHGGVI 121

  Fly   123 CTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQY 187
            |||..:..|:.:|.||::||||.:|.||||.|.||:|.|.:|:|:|.||.||.||.||:|.|..|
Mouse   122 CTQAHKQTAVQLALRVADEMDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSY 186

  Fly   188 QVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPV 252
            .||:||:.|||:||||:|:|:||:|:..|.:|||:|..:.|...|...|:.:.|:::|..: |||
Mouse   187 GVIILDDVHERSLATDVLLGLLKDVLLARPELKLIVNCSPLLTSKLSSYYGDVPVIEVRNK-HPV 250

  Fly   253 EIFYTPEPERDYLEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRIKREIDNLGSEIGELK 317
            |:.|....::|..|:.||.:.:||...| :||:::||..:::||:..:.:.:|..||..::|:|.
Mouse   251 EVVYLSGAQKDSFESVIRLIFEIHRSGE-KGDVVVFLACEQDIEKTYELVCQEGSNLNPDVGDLV 314

  Fly   318 CIPLYSTLPPNLQQRIFEPAPPPNANGAI-GRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYN 381
            .||||    |..:..:|.|.........: .|:||::|:..|:.:....|.||||.|..:::|||
Mouse   315 VIPLY----PKEKCSLFRPVDETEKRCQVYQRRVVLTTSCGESLIWSHTVKFVIDVGLERRQVYN 375

  Fly   382 PRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQ 446
            ||||..||::.|||::.|:.|....|.:..||.|.||||:....:|:.....|:..:||.::||.
Mouse   376 PRIRANSLVLQPISQSQAEIRKQLLGSSPSGKLFCLYTEEFASKDMRPLKPAEMQEANLTSMVLF 440

  Fly   447 LKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIAS 511
            :|::.|..|...|||:.||||:||:|||.|:||||||:||||::.|.:||||||||||:|.::||
Mouse   441 MKRVDIAGLGRCDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILAS 505

  Fly   512 CQHNCSNEILSITAMLSVPQCFVR-PNEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQ---SSE 572
            |:.:|.:|:|:|.||::.|.||:. |:.|::||......|.|.:|||.||:|||:|::.   :|.
Mouse   506 CEFDCVDEMLTIAAMVTAPSCFLHVPHGAEEAAVTCWKTFLHPEGDHFTLINVYNAYQDTVLNSA 570

  Fly   573 DPN----WCYENFINFRSLKSADNVRQQLARIMDRFNLRRTSTEFTSKDYYVNIRKALVQGFFMQ 633
            :.:    ||::.|::..:|:.||.:|.:|..|:.|..|......|.||:..:||:|||:.|:|||
Mouse   571 NEHCVEMWCHDCFLSCSALRMADVIRAELLEIIKRIELPYAEPAFGSKENGLNIKKALLSGYFMQ 635

  Fly   634 VAH-LERTGYYLTIKDNQNVQLHP--STCLDHK-PDWVIYNEFVLTTKNYIRTVTDVKPEWLCCL 694
            :|. ::.:|.||.:...|..||||  |..:..| |:||::::|.::..||||..:.|.||....|
Mouse   636 IARDVDGSGNYLMLTHKQVAQLHPLSSYSITKKMPEWVLFHQFSISENNYIRVASAVSPELFMQL 700

  Fly   695 APQYYDLNNFPQCEAKRQLELLQQ---RLETKQYQK 727
            .|||| .:|.|..|:|   ::|||   .|.|:...|
Mouse   701 VPQYY-FSNLPPSESK---DILQQAAGHLPTETVNK 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	19/51 (37%)
		DEXDc	67..255	CDD:214692	85/189 (45%)
		DEXDc	91..228	CDD:238005	68/138 (49%)
		HELICc	315..408	CDD:197757	33/93 (35%)
		HA2	478..561	CDD:214852	44/83 (53%)
		OB_NTP_bind	595..698	CDD:285018	40/106 (38%)
Dhx32	NP_001272959.1	HrpA	19..687	CDD:224557	270/682 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920