DRSC/TRiP Functional Genomics Resources

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Protein Alignment cos and Kif27

DIOPT Version :9

Sequence 1:NP_001260765.1 Gene:cos / 35653 FlyBaseID:FBgn0000352 Length:1201 Species:Drosophila melanogaster
Sequence 2:NP_780423.2 Gene:Kif27 / 75050 MGIID:1922300 Length:1394 Species:Mus musculus


Alignment Length:1335 Identity:315/1335 - (23%)
Similarity:540/1335 - (40%) Gaps:393/1335 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   145 SSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLTDSTEGVVQLCVRDI 209
            :|:|::||:..:.||:...:||::|:|..|||.|.||:||: |.....::.:..:|::...:::|
Mouse    54 NSTQDEVYNTCIKPLVLSLIEGYNATVFAYGQTGSGKTYTI-GGGHVASVVEGQKGIIPRAIQEI 117

  Fly   210 FSHISLHPERTYAINVGFVEICGGDVCDLL----GMGNIH----------------C--TNVDAV 252
            |..||.:|...:.|.|.::|:...|:.|||    .|.::|                |  .:|:.|
Mouse   118 FQSISENPSIDFKIKVSYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVIVGAKECQVESVEDV 182

  Fly   253 FHWLQVGLSAR---------QSLPAHTLFTLTLEQ-----------QWVSKEGLLQHRLSTASFS 297
            ...||||.:||         .|..:|.:||:::.|           :|.|.    :|.:|...|.
Mouse   183 MSLLQVGNAARHTGTTQMNEHSSRSHAIFTISVCQVEKNAEAAENGEWYSH----RHIVSKFHFV 243

  Fly   298 DLCGTER------CGDQ-PPGRPLDAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTTLTTLLKDS 355
            ||.|:||      .|:: .....:::||..|..|||.|.||...   :.:|||....:|.|||||
Mouse   244 DLAGSERVTKTGNTGERFKESIQINSGLLALGNVISALGDPRRK---SSHIPYRDAKITRLLKDS 305

  Fly   356 FGGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTM------IVQPAEPV 414
            .||.|:|::|.||||......|:|.:|::|.:.:.:||...:|.....:.|      |....|.:
Mouse   306 LGGSAKTVMITCVSPSSSDFDESLNSLKYANRARNIRNKPALNISPQADRMDEMEFEIKLLREAL 370

  Fly   415 PESNSSAGPLSQAG----PGDN--FGLQFAASQ-------WSKLVTNAEGLFSKLIDSKLITEVE 466
            ....:|....|||.    |..|  ..|:...:|       :...:..|......|.|:..:.:.:
Mouse   371 QSHQASISQASQASSENVPDQNRIHSLEEQVAQLQEECLGYQDCIEQAFAFLVDLKDAVKLNQKQ 435

  Fly   467 KEQIEEW---------------------------------LFLKQECE--ECLSST--------- 487
            :.:::||                                 |.||:|.:  :|..:.         
Mouse   436 QHKLQEWFSRTQEVRKAVLTPLPGNQGIGNLEEGPQHLTVLQLKRELKKYQCALAADQVVFTQKD 500

  Fly   488 ---EAMRQQKQL---------VPILEAEEPEDVNSE----------------AANSES-PNSDNE 523
               |.:|.|.||         |.:.||::...:.:|                |..|.| |.|..|
Mouse   501 LELEELRTQVQLMMQESKGHAVSLKEAQKVNRLQNEKIIEQQLLVDQLSAELAKRSLSVPTSAKE 565

  Fly   524 NDTDN---------------ESH---------RPDLDD--------KIESLMEEFRDKTDALI-- 554
            :..|.               |||         |.|...        .::.:...||.::..|:  
Mouse   566 SCGDGPDARASEKRPHTAPFESHWGHYVYIPSRQDFKKVCSSTPVYSLDQVFAGFRTRSQMLMGH 630

  Fly   555 LEKHAEYLSKHPKAVMQSQDREIEAQPPEENGDDRKVSIGSRRRS--VQPGASLSTAELAMLNRV 617
            ||...|.|  |.:....|.|.:.|.|        .|..:.||..|  .:||:..|..||:     
Mouse   631 LEDQDEVL--HCQFSDNSDDEDSEGQ--------EKPRVRSRSHSWAKKPGSVCSLVELS----- 680

  Fly   618 ASQQPPPPIDPESVVDPLESSSGEGIRQAALAAAAATAPIEQLQ-------KKLRKLVAEIEGKQ 675
                       ::..:...|..|.|           ...:|.||       :|||.....:...:
Mouse   681 -----------DTQAESQRSYLGNG-----------DLKMESLQESQEINLQKLRTSELILNKAK 723

  Fly   676 RQLREIEETIQVKQNIIAELVKNSDTRSHAKQRFHKKRAKLEAECDKAK-------KQLGKALVQ 733
            :::||:...|::|:::|.||:|..:......:::..|..|||.|.::||       |||.:  ::
Mouse   724 QKMRELTINIRMKEDLIKELIKTGNNAKSVSRQYSLKVTKLEHEAEQAKVELTETRKQLQE--LE 786

  Fly   734 GRDQSEIERWTTI--------------IGHLERRLEDLSSMKHIAGESGQKVKKLQQSVGESRKQ 784
            .:|.|::.....:              :..|:::.:|...:..::.::.::..:|:.:|...:.|
Mouse   787 SKDLSDVALKVKLQKEFRKKMDAAKMRVQVLQKKQQDSKKLASLSIQNEKRASELEHNVDHLKYQ 851

  Fly   785 ADDLQKKLRKECKLRCQMEAELAKLRESRETGKEL-VKA-QG-------------------SPEQ 828
            ...||::||:|.:.:.|::||   ::..::..||| :|| ||                   ||.:
Mouse   852 KVQLQRRLREEGEKKKQLDAE---IKRDQQKIKELQLKAGQGEGLNPKAEDQDGFNLNRRKSPFR 913

  Fly   829 QGRQLK----------------------------------------------------------- 834
            .|.|.:                                                           
Mouse   914 SGDQFQKLDEQRKWLDEEVEKVLSQRQELEMLEEDLKKREAIVSKKEALLQEKSLLENKKLRSSQ 978

  Fly   835 -------AVQARITHLNHILREKSDNLEEQPGPEQQETLRHEIRNLRGTRDLLLEERCHLDRKLK 892
                   .:.||:..|:..|.|||..||..| .|::..:..:::.|:..||.|..:|..:|.:||
Mouse   979 ALSTDGLKISARLNLLDQELSEKSLQLESSP-TEEKMKISEQVQALQRERDQLQRQRNSVDERLK 1042

  Fly   893 RDKVLTQKEERKLLECDEAIEAIDAAIEFKNEMITGHRSIDTSDRIQREKGEQMLMARLNRLSTE 957
            ..:||:.|||..|.:.:|.|||::||||||||.|...::...:......:.|..::.:|..|:..
Mouse  1043 HGRVLSPKEEHLLFQLEEGIEALEAAIEFKNESIQSRQNSLKASFQNLSQSEANVLEKLVCLNIT 1107

  Fly   958 EMRTLLYKYFTKVIDLRDSSRKLELQ-----LVQLERERDAWEWKERVLSNAVRQARLEGERNAV 1017
            |:|.:|:|||.|||:||::.||.:||     :..|||:....|     |.:|:...||:.:|...
Mouse  1108 EIRAILFKYFNKVINLRETERKQQLQNKEMKMKVLERDNVVHE-----LESALEHLRLQCDRRLT 1167

  Fly  1018 LLQRQHEMKLTLMLRHMAEETSAS----SASYGERALAPACVAPPVQASSDFDYDHFYKGGGNPS 1078
            |.|::||.|:.|:|:|..::...|    ..:|.::.         .|...|.   :|||   ..|
Mouse  1168 LQQKEHEQKMQLLLQHFKDQDGDSIIETLKNYEDKI---------QQLEKDL---YFYK---KTS 1217

  Fly  1079 KALIKAPKPMPTGSALDKYKDKEQRSGRNIFAKFHVLTRYASAAAAGSSGSTAEESTALIESTTT 1143
            :.|.|..|....|:|      :.||:          ||.:..   ||......||:|.|.|....
Mouse  1218 RDLKKRLKDPAQGAA------QWQRT----------LTEHHD---AGDGVLNPEETTVLSEELKW 1263

  Fly  1144 ATATTTSTTTTGAVGKVKDKALVSFRPEQLKRLMP 1178
            | :.|.:|...|:..:| |.:..|.:.:.|.:.:|
Mouse  1264 A-SRTENTKLNGSEREV-DNSSSSLKTQPLTQQIP 1296

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cosNP_001260765.1 Motor_domain 132..389 CDD:277568 90/292 (31%)
SPEC 657..856 CDD:295325 58/313 (19%)
Kif27NP_780423.2 KISc_KIF4 4..342 CDD:276823 90/295 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 559..582 4/22 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 642..665 7/30 (23%)
Smc 721..>1096 CDD:224117 83/380 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 886..916 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1267..1319 8/31 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1325..1344
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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