DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cos and kif7

DIOPT Version :9

Sequence 1:	NP_001260765.1	Gene:	cos / 35653	FlyBaseID:	FBgn0000352	Length:	1201	Species:	Drosophila melanogaster
Sequence 2:	NP_001014816.1	Gene:	kif7 / 544651	ZFINID:	ZDB-GENE-050307-1	Length:	1363	Species:	Danio rerio

Alignment Length:	1209	Identity:	282/1209 - (23%)
Similarity:	475/1209 - (39%)	Gaps:	405/1209 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 SSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLTDSTEGVVQLCVRDIF 210
            |:||:||...|.|||..|..||:|:|..|||.|.||:||: |........|..:|::...|.:||
Zfish    65 STQEEVYTNCVQPLIEAFFHGFNATVSAYGQTGSGKTYTI-GEASISAFRDDEQGIIPRAVAEIF 128

  Fly   211 SHISLHPERTYAINVGFVEI------------------------------CGGDVCDLLGMGNIH 245
            ..:..:....:::.|.::|:                              ||...|::.|:
Zfish   129 KLLDENDLIDFSVRVSYMEVYKEVFRDLLEVETASKDIHIREDERGNVVLCGVKECEVEGL---- 189

  Fly   246 CTNVDAVFHWLQVGLSAR---------QSLPAHTLFTLTLEQQ---WVSKEGLLQHRLSTASFSD 298
                |.|...|:.|.:||         .|..:||:||:.:||:   ..:..|.:|...|...|.|
Zfish   190 ----DEVLSLLESGKTARHTGATQMNPHSSRSHTIFTVLMEQRRGGSRAANGSVQILSSKFHFVD 250

  Fly   299 LCGTER------CGDQ-PPGRPLDAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTTLTTLLKDSF 356
            |.|:||      .|:: .....:::||.:|..||..|.||...   ..:|||..:.:|.:||||.
Zfish   251 LAGSERILKTGNTGERLKESIQINSGLLVLGNVIGALGDPKRK---GTHIPYRDSKITRILKDSL 312

  Fly   357 GGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSD------------------- 402
            ||.|:||:|.|:||......|:|..|.:|.:.:.::|...:|...:
Zfish   313 GGNAKTLMIACISPSSSDFDESLNTLNYAKRARNIQNRATVNCRGEPDRIEGLELQIKALRRALE 377

  Fly   403 ----DNTMIVQPAEPVPESNSSAGPLSQAGPGDNFGLQFAASQWSKLVTNAEGLFSKLIDSKLIT 463
                ..|.|:..::|    .....|...    |...||..::.:.....:|         .:|:|
Zfish   378 NRQRSETRIIARSDP----EKRLRPFEV----DVRKLQAESAHYRTCTDSA---------YRLLT 425

  Fly   464 EVEKE---------QIEEWLFLKQECEECLSSTEAMRQQKQLVPILEAEEPED----------VN 509
            |::.|         :::|||...:|....|:|...:...      :|:...||          :|
Zfish   426 ELQGEGTLNAGQILRVKEWLCGVEEERSGLTSASGLDSG------IESSSTEDSTALKRRQAVLN 484

  Fly   510 SEAANSESPNSDNENDTDN--------ESHRPDLDDKIESLMEEFRDKTDA------LILEKHA- 559
            ::....|....:.|:.|..        |....|....:|..||:::.::|.      ||.|.|:
Zfish   485 NQDLVKEDWRGEREDYTSQLQAQIQQLEQENTDFLVALEDAMEQYKQQSDKLQEQQDLIAELHSL 549

  Fly   560 ---------EYLSKHP-----KAVMQSQDREIEAQPPEENGDDRKVSIGSRRRSVQPGASLSTAE 610
                     .:|.:.|     .:::|:.||   ..||.::...|.::     |.:..|||:.::.
Zfish   550 LAQPGGAGFLHLKQRPHTAPINSLLQTPDR---LTPPCDSDVGRSLA-----RQLDVGASVDSSS 606

  Fly   611 LA------------------MLNR------------------------VASQQPP---------- 623
            .:                  .|||                        :|..|.|
Zfish   607 YSEQTQWDGTHGNTHCESSRKLNRDEDGHMQTTRDKRKSINVTWTKKDIAIPQGPFGGTRTALPQ 671

  Fly   624 ------------------PPIDPESVVDPLESSSGE-----GIRQAALAAAAATAPIEQLQKKLR 665
                              ..|...||.:.:....||     |:.||
Zfish   672 TLGLCHPLGMQFNRRTSNSSIGESSVWESVRGFGGEFCSDRGLLQA------------------- 717

  Fly   666 KLVAEIEGKQRQLREIEETIQVKQNIIAELVKNSDTRSHAKQRFHKKRAKLEAECDKAK------ 724
                     |:::||:..||::|:.:|.||||.........:::.:|.::||||.::|:
Zfish   718 ---------QQKIRELSITIRMKEELIKELVKTGKDAQAMNRQYSRKISELEAEAEQARVELTEA 773

  Fly   725 -KQLGKALVQ-GRD-----------------QSEIERWTTIIGHLERRLEDLSSMKHIAGESGQK 770
             |||.:..|| |||                 ||:::       .|:::..|.:.:..::.:|.::
Zfish   774 QKQLQELEVQGGRDAVDRSKAQECRRKIAAAQSKVQ-------VLKQKQRDTAQLASLSAQSERR 831

  Fly   771 VKKLQQSVGESRKQADDLQKKLRKECKLRCQMEAELAK--------------------------- 808
            |::|:::|...::|.|.||::||:|.:.:.::|.|:.|
Zfish   832 VQELERNVQNMKQQQDLLQRRLREESQQKRRLETEMQKGKHRVKELEIKNEQQQKILRIKTEEIA 896

  Fly   809 -LRESRETGK-----ELVKAQGSPEQ-------------QGRQLKAVQARITHLNHILREKSDNL 854
             .:..|.:|.     .|.:.|...||             |.|.|:.::..:|....||.:|...|
Zfish   897 AFQRQRRSGSNGSVVSLEEQQKIEEQKRWLDEEMEKVLDQRRGLEDLEGELTKREEILAKKEALL 961

  Fly   855 EEQPGPEQQ-----------------------------------------ETLRHEIRNLRGTRD 878
            .|:.|.|.:                                         :.:|.||.|||..::
Zfish   962 WERSGLESKKLRSSQALSQDLLTLSSRIESLERELTERNGLLRSGSAQDSQQIRQEISNLRQEKE 1026

  Fly   879 LLLEERCHLDRKLKRDKVLTQKEERKLLECDEAIEAIDAAIEFKNEMITGHRSIDTSDRIQREKG 943
            |||::|..||.||::..:|:.:|||.|.:.||||||:|||||:|||.||..:      |..|..|
Zfish  1027 LLLKQRVELDDKLRQGNLLSPEEERTLFQLDEAIEALDAAIEYKNEAITQRQ------RQLRASG 1085

  Fly   944 ------EQMLMARLNRLSTEEMRTLLYKYFTKVIDLRDSSRKLELQLVQL----ERERDAWEWKE 998
                  |..|||:|..||..|.|.||.|||.||:.||:..|:|::.|.:|    |.:::...|
Zfish  1086 SMLTQWEMNLMAKLTYLSASETRALLCKYFDKVVSLREEERRLQMALAELELRVEEQQNLVGW-- 1148

  Fly   999 RVLSNAVRQARLEGERNAVLLQRQHEMKLTLMLRHMAEE 1037
              |..|:.:.:||.:|.....|::||..:.|:|:...|:
Zfish  1149 --LEAALERQQLEADRRLTQQQKEHERNIQLLLQQCREQ 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	86/291 (30%)
cos	NP_001260765.1	SPEC	657..856	CDD:295325	57/269 (21%)
kif7	NP_001014816.1	KISc_KIF4	14..348	CDD:276823	86/294 (29%)
		KISc	15..354	CDD:214526	87/300 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..642		3/38 (8%)
		PspA_IM30	716..924	CDD:281941	51/242 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1314..1346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910