Protein Alignment cos and kif7

DIOPT Version :10

• Sequence 1: NP_477092.1
• Gene: cos / 35653
• FlyBaseID: FBgn0000352
• Length: 1201
• Species: Drosophila melanogaster
• Sequence 2: NP_001014816.1
• Gene: kif7 / 544651
• ZFINID: ZDB-GENE-050307-1
• Length: 1363
• Species: Danio rerio
• Alignment Length: 1209
• Identity: 282/1209 - (23%)
• Similarity: 475/1209 - (39%)
• Gaps: 405/1209 - (33%)

  Fly   146 SSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLTDSTEGVVQLCVRDIF 210
            |:||:||...|.|||..|..||:|:|..|||.|.||:||: |........|..:|::...|.:||
Zfish    65 STQEEVYTNCVQPLIEAFFHGFNATVSAYGQTGSGKTYTI-GEASISAFRDDEQGIIPRAVAEIF 128

  Fly   211 SHISLHPERTYAINVGFVEI------------------------------CGGDVCDLLGMGNIH 245
            ..:..:....:::.|.::|:                              ||...|::.|:
Zfish   129 KLLDENDLIDFSVRVSYMEVYKEVFRDLLEVETASKDIHIREDERGNVVLCGVKECEVEGL---- 189

  Fly   246 CTNVDAVFHWLQVGLSAR---------QSLPAHTLFTLTLEQQ---WVSKEGLLQHRLSTASFSD 298
                |.|...|:.|.:||         .|..:||:||:.:||:   ..:..|.:|...|...|.|
Zfish   190 ----DEVLSLLESGKTARHTGATQMNPHSSRSHTIFTVLMEQRRGGSRAANGSVQILSSKFHFVD 250

  Fly   299 LCGTER------CGDQ-PPGRPLDAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTTLTTLLKDSF 356
            |.|:||      .|:: .....:::||.:|..||..|.||...   ..:|||..:.:|.:||||.
Zfish   251 LAGSERILKTGNTGERLKESIQINSGLLVLGNVIGALGDPKRK---GTHIPYRDSKITRILKDSL 312

  Fly   357 GGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSD------------------- 402
            ||.|:||:|.|:||......|:|..|.:|.:.:.::|...:|...:
Zfish   313 GGNAKTLMIACISPSSSDFDESLNTLNYAKRARNIQNRATVNCRGEPDRIEGLELQIKALRRALE 377

  Fly   403 ----DNTMIVQPAEPVPESNSSAGPLSQAGPGDNFGLQFAASQWSKLVTNAEGLFSKLIDSKLIT 463
                ..|.|:..::|    .....|...    |...||..::.:.....:|         .:|:|
Zfish   378 NRQRSETRIIARSDP----EKRLRPFEV----DVRKLQAESAHYRTCTDSA---------YRLLT 425

  Fly   464 EVEKE---------QIEEWLFLKQECEECLSSTEAMRQQKQLVPILEAEEPED----------VN 509
            |::.|         :::|||...:|....|:|...:...      :|:...||          :|
Zfish   426 ELQGEGTLNAGQILRVKEWLCGVEEERSGLTSASGLDSG------IESSSTEDSTALKRRQAVLN 484

  Fly   510 SEAANSESPNSDNENDTDN--------ESHRPDLDDKIESLMEEFRDKTDA------LILEKHA- 559
            ::....|....:.|:.|..        |....|....:|..||:::.::|.      ||.|.|:
Zfish   485 NQDLVKEDWRGEREDYTSQLQAQIQQLEQENTDFLVALEDAMEQYKQQSDKLQEQQDLIAELHSL 549

  Fly   560 ---------EYLSKHP-----KAVMQSQDREIEAQPPEENGDDRKVSIGSRRRSVQPGASLSTAE 610
                     .:|.:.|     .:::|:.||   ..||.::...|.::     |.:..|||:.::.
Zfish   550 LAQPGGAGFLHLKQRPHTAPINSLLQTPDR---LTPPCDSDVGRSLA-----RQLDVGASVDSSS 606

  Fly   611 LA------------------MLNR------------------------VASQQPP---------- 623
            .:                  .|||                        :|..|.|
Zfish   607 YSEQTQWDGTHGNTHCESSRKLNRDEDGHMQTTRDKRKSINVTWTKKDIAIPQGPFGGTRTALPQ 671

  Fly   624 ------------------PPIDPESVVDPLESSSGE-----GIRQAALAAAAATAPIEQLQKKLR 665
                              ..|...||.:.:....||     |:.||
Zfish   672 TLGLCHPLGMQFNRRTSNSSIGESSVWESVRGFGGEFCSDRGLLQA------------------- 717

  Fly   666 KLVAEIEGKQRQLREIEETIQVKQNIIAELVKNSDTRSHAKQRFHKKRAKLEAECDKAK------ 724
                     |:::||:..||::|:.:|.||||.........:::.:|.::||||.::|:
Zfish   718 ---------QQKIRELSITIRMKEELIKELVKTGKDAQAMNRQYSRKISELEAEAEQARVELTEA 773

  Fly   725 -KQLGKALVQ-GRD-----------------QSEIERWTTIIGHLERRLEDLSSMKHIAGESGQK 770
             |||.:..|| |||                 ||:::       .|:::..|.:.:..::.:|.::
Zfish   774 QKQLQELEVQGGRDAVDRSKAQECRRKIAAAQSKVQ-------VLKQKQRDTAQLASLSAQSERR 831

  Fly   771 VKKLQQSVGESRKQADDLQKKLRKECKLRCQMEAELAK--------------------------- 808
            |::|:::|...::|.|.||::||:|.:.:.::|.|:.|
Zfish   832 VQELERNVQNMKQQQDLLQRRLREESQQKRRLETEMQKGKHRVKELEIKNEQQQKILRIKTEEIA 896

  Fly   809 -LRESRETGK-----ELVKAQGSPEQ-------------QGRQLKAVQARITHLNHILREKSDNL 854
             .:..|.:|.     .|.:.|...||             |.|.|:.::..:|....||.:|...|
Zfish   897 AFQRQRRSGSNGSVVSLEEQQKIEEQKRWLDEEMEKVLDQRRGLEDLEGELTKREEILAKKEALL 961

  Fly   855 EEQPGPEQQ-----------------------------------------ETLRHEIRNLRGTRD 878
            .|:.|.|.:                                         :.:|.||.|||..::
Zfish   962 WERSGLESKKLRSSQALSQDLLTLSSRIESLERELTERNGLLRSGSAQDSQQIRQEISNLRQEKE 1026

  Fly   879 LLLEERCHLDRKLKRDKVLTQKEERKLLECDEAIEAIDAAIEFKNEMITGHRSIDTSDRIQREKG 943
            |||::|..||.||::..:|:.:|||.|.:.||||||:|||||:|||.||..:      |..|..|
Zfish  1027 LLLKQRVELDDKLRQGNLLSPEEERTLFQLDEAIEALDAAIEYKNEAITQRQ------RQLRASG 1085

  Fly   944 ------EQMLMARLNRLSTEEMRTLLYKYFTKVIDLRDSSRKLELQLVQL----ERERDAWEWKE 998
                  |..|||:|..||..|.|.||.|||.||:.||:..|:|::.|.:|    |.:::...|
Zfish  1086 SMLTQWEMNLMAKLTYLSASETRALLCKYFDKVVSLREEERRLQMALAELELRVEEQQNLVGW-- 1148

  Fly   999 RVLSNAVRQARLEGERNAVLLQRQHEMKLTLMLRHMAEE 1037
              |..|:.:.:||.:|.....|::||..:.|:|:...|:
Zfish  1149 --LEAALERQQLEADRRLTQQQKEHERNIQLLLQQCREQ 1185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cos	NP_477092.1	Kinesin	140..389	CDD:459720	86/291 (30%)
		SMC_N	660..>999	CDD:481474	122/460 (27%)
kif7	NP_001014816.1	KISc_KIF4	14..348	CDD:276823	86/294 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	603..642		3/38 (8%)
		Smc	<714..>1231	CDD:440809	135/517 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1314..1346