Protein Alignment cos and Klp98A

DIOPT Version :9

• Sequence 1: NP_001260765.1
• Gene: cos / 35653
• FlyBaseID: FBgn0000352
• Length: 1201
• Species: Drosophila melanogaster
• Sequence 2: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Alignment Length: 1206
• Identity: 251/1206 - (20%)
• Similarity: 430/1206 - (35%)
• Gaps: 367/1206 - (30%)

  Fly   143 PSSSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLTDSTEGVVQLCVR 207
            |..::|||||......::....||::|.|..|||.|.||::|:.|...:|.|      :.::| .
  Fly    68 PHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGL------IPRIC-E 125

  Fly   208 DIFSHISLHPE-----RTYAINVGFVEICGGDVCDLL-----GMG--------------NI--HC 246
            ::|:.:.:..|     ||:|   .::||....|.|||     |.|              |:  |.
  Fly   126 ELFARMRVGQESGTGYRTHA---SYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHA 187

  Fly   247 -TNVDAVFHWLQVGLSAR---------QSLPAHTLFTLTLEQQWVSKEGLLQHRLSTASFSDLCG 301
             ::.|.:...:..|.:.|         .|..:|.:||:|..|. |....:....:|.....||.|
  Fly   188 VSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQA-VFMNDMPSETVSKIHLVDLAG 251

  Fly   302 TERC------GDQ-PPGRPLDAGLCMLEQVISTLTD----------PGLMYGVNG------NIPY 343
            :||.      |.: ..|..::..|..|..|||.|.:          ..|....||      .|||
  Fly   252 SERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPY 316

  Fly   344 GQTTLTTLLKDSFGGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTMIV 408
            ..:.||.|||||.||.::|::|..:||.:.:..|||..|::|.:.:.:.|...:|  .|.|..::
  Fly   317 RDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVN--EDTNVKLI 379

  Fly   409 QPAEPVPESNSSAGPLSQAGPGDNFGLQFAASQWSKLVTNAEGLFSKLIDSKLITEVEKEQIEEW 473
            :      |.......|.....||...||.:.                    |::.:::|::.:|.
  Fly   380 R------ELREEINKLKSMLAGDIHSLQPSL--------------------KVLADLQKKEAQEK 418

  Fly   474 LFLKQECEECLSSTEAMRQQKQL------VPILEAEEPEDVNSEAANSESPNSDNENDTDNESHR 532
            :..::..|:...:...:::||.|      |.::
  Fly   419 VLTEEWTEKWKVAQSILQEQKSLGLRKSGVGVV-------------------------------- 451

  Fly   533 PDLDDKIESLMEEFRDKTDALILEKHAEYLSKHPKAVMQSQDREIEAQPPEENGDDRKVSIGSRR 597
              ||.::..|:....|.|..:.|     |..|..:..:.|:|.:: ||..|..||
  Fly   452 --LDSEMPHLIGIHNDVTTGVTL-----YSLKEGETRIGSEDADV-AQDIELAGD---------- 498

  Fly   598 RSVQPGASLSTAELAMLNRVASQQPPPP----IDPESVVDPLESSSGEGIRQAALAAAAATAPIE 658
                 |.......:.:...|.:..|.|.    ::...:.:|.:.|.|:.|............|.|
  Fly   499 -----GIRAQHCSIFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAE 558

  Fly   659 QLQKKLRKLVAEIEGKQRQLREIEETIQVKQNII-AELVKNSDTRSHAKQRFHKKRAKLEAECDK 722
              ..||||   ::...|..:..:......|:|:: ..:..:.|..|..|               :
  Fly   559 --AAKLRK---DLSRSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYK---------------R 603

  Fly   723 AKKQLGKALVQGRDQSEIERWTTIIGHLERRLEDLSSMKHIAGESGQKVKKLQQSVGESRKQADD 787
            .::|........||..|::                                     .|:||..|.
  Fly   604 PERQYYPQRPMSRDDPELQ-------------------------------------DENRKILDT 631

  Fly   788 LQKKLRKECKLRCQMEAEL-AKLRESRETGKELVKAQGSPEQQGRQLKAVQARITHLNHILREKS 851
            ::..|::....|.||..:. .|:|:..|   ||::.: ..|..|.||.
  Fly   632 IENALKQLNVERVQMHDQYKTKVRKLTE---ELIRLE-QEEMDGLQLL----------------- 675

  Fly   852 DNLEEQPGPEQQETLRHEIRNLRGTRDLLLEE----RCHLDRKLKRD-KVLTQKEERKLLEC--- 908
             |..||....:::.|..|..|.:...|::..:    :..||.| ||| .....||.::|.:|
  Fly   676 -NCREQELIARKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSK-KRDFSEYVAKELQELQDCGKL 738

  Fly   909 DEAIEAIDAAIEFKNEMITG-HRSID------TSDRIQREKGEQMLMARLNRLSTEEMRTLLYKY 966
            ||....|:......:|::.. ..|:|      ..|.::|...|   :.:|:....|:.| :|...
  Fly   739 DEMGMKIEEGTPLNDELLLQVSDSLDLFAAQFIKDTVRRNNEE---IRKLDEQIAEKER-ILNAS 799

  Fly   967 FTKVIDLRDSSRKLELQLVQLERERDAWEWKERVLSNAVRQARLEGERNAVLLQRQHEMKLTLML 1031
            .||:..:.::..:::.||.:|..||                |..|.|..|:..::|: |||.|..
  Fly   800 TTKIAKVDETMLEIQAQLERLRLER----------------AESEAESQAMRAKKQN-MKLQLGN 847

  Fly  1032 RHMAEETSASSASYGERALAPACVAPPVQASSDFD-YDHFYKGGGNPSKALIKAP-------KPM 1088
            :.|:..||.:.|.             .|..|..:: .|.|:....|.|  |:.:|       .|:
  Fly   848 KSMSTSTSTNEAD-------------DVSKSDTYETCDTFHTAQSNLS--LVSSPTITEGQQSPL 897

  Fly  1089 PTGS--ALDKYKD--KEQRSGRNIFAKFHVLTRYASAAAAGSSGSTA------------------ 1131
            ...|  |.|:.:|  |:..||.:     ...:|..:|..:..|||.:
  Fly   898 SNCSCDAEDEAEDTRKDDLSGSS-----EETSRTCTAGPSSGSGSGSVGIGGSGSAPSCTPSSQA 957

  Fly  1132 --EESTALIESTTTA-----------TATTTSTTTTGA-----VGKVKDKALVSFRP----EQLK 1174
              .:|...::|...|           .|..||...||:     :|:..|.|    ||    ..|:
  Fly   958 IMSDSGVCLDSRNQAILQNGHLNNYKQAVRTSDEDTGSCSSCELGRHSDVA----RPYCPLHSLR 1018

  Fly  1175 RLMPAPTA----------TKVTRQKNKIIIQDASRR 1200
            |.:.|..|          .|....::...:||..||
  Fly  1019 RKIAAQKALIMKNLETDLNKAQLDEHIADLQDLQRR 1054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	84/304 (28%)
		SPEC	657..856	CDD:295325	33/200 (17%)
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	85/313 (27%)
		KISc	3..371	CDD:214526	85/313 (27%)
		Kinesin_assoc	370..478	CDD:292801	25/174 (14%)
		FHA	456..555	CDD:238017	21/119 (18%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437722
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030