Protein Alignment cos and Kif19A

DIOPT Version :10

• Sequence 1: NP_477092.1
• Gene: cos / 35653
• FlyBaseID: FBgn0000352
• Length: 1201
• Species: Drosophila melanogaster
• Sequence 2: NP_996208.1
• Gene: Kif19A / 41717
• FlyBaseID: FBgn0038205
• Length: 750
• Species: Drosophila melanogaster
• Alignment Length: 949
• Identity: 195/949 - (20%)
• Similarity: 310/949 - (32%)
• Gaps: 356/949 - (37%)

  Fly   133 PHTVPVTHALPSSSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNV-------- 189
            |......|....:.||||||..|..||:...|.|.:|:|..||..|.||::|:.|.|
  Fly    71 PRQYSYDHVFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTS 135

  Fly   190 --QDPTLT-DSTE------GVVQLCVRDIFSHISLHPERTYAINVGFVEICGGDVCDLL------ 239
              ..||.: |||:      |::...:.||||||......:..:::.::||....:.|||
  Fly   136 DRAPPTASCDSTDVSSQDIGLMVRAIEDIFSHIESAEAYSCRVSISYLEIYNELIRDLLNPGGPL 200

  Fly   240 --------------GMGNIHCTNVDAVFHWLQVGLSARQSLP---------AHTLFTLTLEQQWV 281
                          |:..|..::...|...|..|..||...|         :|.|.::.::.:
  Fly   201 ELREDHRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQAR-- 263

  Fly   282 SKEGLLQHRLSTASFSDLCGTERC------GDQ-PPGRPLDAGLCMLEQVISTLTDPGLMYGVNG 339
            :..|..|.||   ..:||.|:||.      |.: ..|..::..|..|..||:.|:. |..|
  Fly   264 TPLGTKQGRL---FLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGLSG-GARY---- 320

  Fly   340 NIPYGQTTLTTLLKDSFGGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDN 404
             :.|..:.||.|||::..||.:|::|..|:|..:|..||...|                .|:|
  Fly   321 -VNYRDSKLTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTL----------------VYAD-- 366

  Fly   405 TMIVQPAEPVPESNSSAGPLSQAGPGDNFGLQFAASQWSKLVTNAEGLFSKLIDSKLITEVEKEQ 469
                                                       .|..:.:||.:|..|.|.:
  Fly   367 -------------------------------------------RANSITTKLQNSVYIDEFK--- 385

  Fly   470 IEEWLFLKQECEECLSSTEAMRQQKQLVPILEAEEPEDVNSEAANSESPNSDNENDTDNESHRPD 534
                                                                            |
  Fly   386 ----------------------------------------------------------------D 386

  Fly   535 LDDK-IESLMEEFRDKTDALILEKHAEYLSKHPKAVMQSQDREIEAQPPEENGDDRKVSIGSRRR 598
            ...| .:||:.|.||:...|    ..:.|::.|::
  Fly   387 FPTKHYQSLVSELRDEVSRL----RTKMLTERPRS------------------------------ 417

  Fly   599 SVQPGASLSTAELAMLNRVASQQPPPPIDPESVVDPLESSSGEGIRQAALAAAAATAPIEQLQKK 663
                ||:.:.|..|                         :||    .|..|.:.|.:...|.|.:
  Fly   418 ----GAAAAAAAAA-------------------------ASG----SAGTAGSGAGSEAVQEQDE 449

  Fly   664 LRKLVAEIEGKQRQLREIEETIQVKQNIIAELVKNSDTRSHAKQRFHKKRAKLEAECDKAKKQLG 728
            .||         .:||.:.|.|.:.                .||:...:|..||||    ...||
  Fly   450 QRK---------TELRYLREQIVLT----------------FKQQMKLRRKLLEAE----SHLLG 485

  Fly   729 KALVQGRDQSEIERWTTIIGHLERRL--EDLSSMKHIAGESGQKVKKLQQSVGESRKQADDLQKK 791
            ..|...|....|..|...||.|...:  :|:.|...:|         |:.:.||...    ::|:
  Fly   486 LELDAERQHMIISHWQGRIGKLYDAMGDDDIESEGSVA---------LKNAWGELAA----IEKE 537

  Fly   792 LRKECKLRCQMEAELAKLRESR-ETGKELVKAQGSPEQQGRQLKAVQARITHLNHILREKSDNLE 855
            .|:..::|.:.|.||.:.|:.. :...||.:...|.|:  |:|.|:..|:    |.|.....:|:
  Fly   538 TRRYKEIRERTEHELEQCRQKGVKLEDELPERISSDEE--RELLALLCRV----HELEADKVSLQ 596

  Fly   856 EQPGPEQQETLRHEIRNLRGTRDLLLEERCHLDRKLKRDKVLTQKEERKLLECDEAIEAIDAAIE 920
            .:....|.|..|.:::.||..|          .|:|..|.:.:|   |:|:|
  Fly   597 AERLARQAELRRRDLQLLRAER----------QRRLCEDIISSQ---RRLIE------------- 635

  Fly   921 FKNEMITGHRSIDTSDRIQREKG--EQMLMARLNRLSTEEMRTLLYKYFTKVIDLRDSSRKLELQ 983
                    ..::|..|.::...|  :|.:.|.:...||......|...:|...|...||...|..
  Fly   636 --------EGNVDLPDELRELYGLYQQEIHAGVVTPSTSNYERKLPPIYTAGSDSPGSSSSSEWS 692

  Fly   984 ----LVQLERERDAWEWKERVLSNAV--RQARLEGERNA 1016
                |.|::.:.|.   .:||:...|  |..||....:|
  Fly   693 PASPLPQIDNQMDP---VDRVMGPPVNPRLPRLSAATSA 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cos	NP_477092.1	Kinesin	140..389	CDD:459720	83/301 (28%)
		SMC_N	660..>999	CDD:481474	76/347 (22%)
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:473979	87/371 (23%)
		SMC_prok_B	<393..672	CDD:274008	85/427 (20%)