DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cos and Klp67A

DIOPT Version :9

Sequence 1:	NP_001260765.1	Gene:	cos / 35653	FlyBaseID:	FBgn0000352	Length:	1201	Species:	Drosophila melanogaster
Sequence 2:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	753	Identity:	147/753 - (19%)
Similarity:	271/753 - (35%)	Gaps:	207/753 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 SSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLTDSTEGVVQLCVRDIF 210
            :|.:.::.:...||:...|.|::.||..||..|.||::|:.|:...|       |:..|.::|:|
  Fly    82 NSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHP-------GLTYLTMQDLF 139

  Fly   211 SHISLHPE-RTYAINVGFVEICGGDVCDLL------------------GMGNIHCTNVDAVFHWL 256
            ..|....: |.:.:.|.::|:....|.:||                  |:......:.:.:...|
  Fly   140 DKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTKSGPLKLREDNNGVVVSGLCLTPIYSAEELLRML 204

  Fly   257 QVGLSARQSLP---------AHTLFTLTLEQQWVSKEGLLQHRLSTASFSDLCGTERCGDQ---- 308
            .:|.|.|...|         :|.:|.:.:.   :::......|....|..||.|:||....
  Fly   205 MLGNSHRTQHPTDANAESSRSHAIFQVHIR---ITERKTDTKRTVKLSMIDLAGSERAASTKGIG 266

  Fly   309 ---PPGRPLDAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTTLTTLLKDSFGGRAQTLVILCVSP 370
               ..|..::..|..|...|:.|.| ||.:     |||..:.||.:||||.||..:||::..||.
  Fly   267 VRFKEGASINKSLLALGNCINKLAD-GLKH-----IPYRDSNLTRILKDSLGGNCRTLMVANVSM 325

  Fly   371 LEEHLPETLGNLQFAFKVQCVRNFVIMNT---------YSDDNTMIVQPAEPVPESN----SSAG 422
            ......:|...|::|.:.:.:|..:..|.         |......:|...|.:.|.|    :.|.
  Fly   326 SSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLKERNKALEAKAT 390

  Fly   423 PLSQAGPGDNFGLQ--------------FAASQWSKLVTNAEGLFSKL----------------- 456
            .|.:||   |.|..              :||::  :|..:..|:.||:
  Fly   391 QLERAG---NSGFDPLELKTWYSKIDAVYAAAR--QLQEHVLGMRSKIKNINYRQTLKKELEEFR 450

  Fly   457 ----ID---------------SKLITEVE--KEQIEEWL----FLKQECEECLSSTEAMRQQKQL 496
                :|               |.|.:::|  ||::..||    ...|:.|.........:..:.|
  Fly   451 KLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKEELPSWLSKMEIAYQDLESLKREVNKSKAYQIL 515

  Fly   497 VPILEAEEPE--------------DVNSEAANS------------ESPNSDNENDTDNESHRPDL 535
            :..::.::.|              .:|.|...:            |..|...:...|.:...|::
  Fly   516 IVYVKYKDLELQLTKQNIFNNHVNAINQELVENLDLMRKSFRTACEVLNQTYDRLEDGQKLTPEI 580

  Fly   536 DDKIESLMEEFRDKTDALILEKHAEYLSKHPKAVMQSQDREIEAQPPEENGDDRKVSIGSRRRSV 600
            :...|.|:.:.|....    |.:.:....:|.||..:    :.:...||......::..:::|..
  Fly   581 EAVFERLLRKMRFADS----EANTKMAEMNPLAVPVA----LRSSAQEEEEPTCSLTASAKKRQR 637

  Fly   601 QPGASLSTAELAM--------------LNRVASQQPPPPIDPESVVDPLESSSGEGIRQAALAAA 651
            |...|.....|:|              |:|...:  |..::...|:.|..|||......::.|..
  Fly   638 QAAQSDDDLHLSMEDFDSQDTESDSEELHRTFKR--PRNLNETQVLGPCSSSSSSSTSSSSSARK 700

  Fly   652 AATAPIEQLQKKLRKLVAE------IEGKQRQLRE------------IEETIQ----VKQNI--I 692
            |.||.:.:.:...::||::      :.|...::::            ::.|:.    .|:|:  .
  Fly   701 ALTATVTKPRTVQQRLVSDLISDQNVRGGNEKIKKALLKSNHFTAQGLQRTLAAASLAKENVKYN 765

  Fly   693 AELVKNSDTRSHAKQRFHKKRAKLEAECDKAKKQLGKA 730
            |..|:.|.....||        .|......|:|.||.|
  Fly   766 ANYVRKSPRALMAK--------ALAGTSTLARKPLGSA 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	67/277 (24%)
cos	NP_001260765.1	SPEC	657..856	CDD:295325	17/98 (17%)
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	68/286 (24%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	67/279 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437872
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030