DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cos and cana

DIOPT Version :9

Sequence 1:	NP_001260765.1	Gene:	cos / 35653	FlyBaseID:	FBgn0000352	Length:	1201	Species:	Drosophila melanogaster
Sequence 2:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster

Alignment Length:	1271	Identity:	230/1271 - (18%)
Similarity:	440/1271 - (34%)	Gaps:	425/1271 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 THALP--------SSSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLT 195
            :||.|        ..:|.::|:.:....::...::|.:.::..|||...||:||:.|:.|:|
  Fly    39 SHAEPYVFDYVFDEGASNQEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNP--- 100

  Fly   196 DSTEGVVQLCVRDIFSHISLHPERTYAINVGFVEICGGDVCDLL--------------GMGNIHC 246
                ||:.|..::||..||...||.:.:.||::||....:.|||              |:.|::|
  Fly   101 ----GVMVLAAKEIFQQISSETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNVNC 161

  Fly   247 -----TNVDAVFHWLQVGLSAR---------QSLPAHTLFTLTLEQQWVSKEGLLQHRLSTASFS 297
                 |:.|.:...|.:|...|         :|..:|.:|.:.:|.:..........:.|..|..
  Fly   162 KESIVTSEDDLLRQLYMGNKERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLV 226

  Fly   298 DLCGTERCGDQPPGRPLD--AGLCMLEQVISTLTD-----PGLMYGVNGNIPYGQTTLTTLLKDS 355
            ||.|:|:..      |.|  :.|.:...::.:|::     |.         .:..:.|..::..|
  Fly   227 DLAGSEQVD------PADHASSLMIFRNLVKSLSESVDSKPN---------SFRDSKLPRIMLPS 276

  Fly   356 FGGRAQTLVILCVSPLEEHLPETLGNLQF---AFKVQC-----------------------VRNF 394
            .||...|.:|..::|  ..:.|:...:.|   |.|::|                       :::.
  Fly   277 LGGNVLTSIICTITP--SFVEESSSTISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDK 339

  Fly   395 VIMNTYSDDNTMIVQPAE-----PVPESNSSAGPLSQAGPGDNFGLQFAASQWSKLVTNAEGLFS 454
            :......:::.:::|..|     .:.:..|||..       |::.||.....|:...:.:||
  Fly   340 LAKKKIKNESQLVLQELEGRIKRDMLKIVSSASL-------DDYRLQKRRRTWTLTASGSEG--- 394

  Fly   455 KLIDSKLITEVEKEQ-----------IEEWLF--------------------------------- 475
               |:.::...|.|:           :.:.||
  Fly   395 ---DAPVLALPEPEESRLPRPSKLTNLPKPLFQRRGIAPKAKGICKTLKEKRLQTDNMDTMPGRA 456

  Fly   476 --LKQECEECLSSTEAMRQQKQLVPILEAEEPEDVNSEAANS----------------------- 515
              |.:|....:.|....::.::.||..:|.:.|.....|:|.
  Fly   457 KQLGRETASRIPSVMMSKKYQESVPNCDAPQTEISALTASNQVAKETIEKYEEQVKRLKETIERL 521

  Fly   516 ESPNSDNENDTDN-ESHRPDLDDKIESLMEEFRDKTDALI-LEKHAEYLSKHPKAVMQSQDREIE 578
            |..|....|..:. |:|:.......|.|:....:|...:: |::..|.||:  ..:..|::.::.
  Fly   522 EMENGKAVNLGEQFETHKAKSKQMEEELLSSISEKDSTIVSLQQSLEELSR--DVLRNSKEDQMR 584

  Fly   579 AQPPE-ENGDDRKVSIGSRRRSVQPGASLSTAE--LAMLNRVASQQPPPPIDPESVVDPLESSSG 640
            :..|| |:..:|..:.......:.|.||.|..:  ....:::.|:.....:..||::.....:|.
  Fly   585 SMCPELESSCERICNKCLELERLLPLASASGLDSVACQFDQLRSEIAATRMKLESMLSTFSHASC 649

  Fly   641 EGIRQAA----LAAAAATAPIE-------------------------------------QLQKKL 664
            |..::..    |:...:||..:                                     |||.:.
  Fly   650 EVSQKTTDCKRLSEQISTAHDDFGQLQEKYNNLKHKWSSQKLAIDTMQVDYNTIQQKYLQLQDEY 714

  Fly   665 RKLVAEIEGKQRQLREIEETIQVK--------QNIIAEL--VKNSDTRSH----AKQRFHKKRAK 715
            |.|....:.:.:||::....:|.:        :.|.:||  |.|.||...    ..|...|:.:|
  Fly   715 RHLELRSDEQCQQLQDENSKLQAEIGTLKERVEEIHSELLEVPNPDTHPEDMELQNQELKKRLSK 779

  Fly   716 LEAECDKAKKQLGKALVQGRDQSEIERWTTIIGHLERRL--EDLSSMKHIAGESG---------- 768
            |:.|.|:.  ||....:.....|.|:....:....::|.  .||.|||    .||
  Fly   780 LQWEFDEI--QLNYECLSNELMSTIQECDALREEHKQRTTNSDLESMK----SSGVGTECSDPEN 838

  Fly   769 -------QKVKKLQQSVGE-------------------------SRKQADDLQKKLRKECK---- 797
                   |:..||.:|:.:                         |.|...:..|.|..:.|
  Fly   839 ELDTDLLQQFTKLSKSIQQIELTDYSGGRRLFIYNHAEQDQSVPSLKLCLEPAKYLEGDGKQHDA 903

  Fly   798 ---------LRCQ--------MEAELAK-----------LRESRETGKELVKAQGSPEQQGRQLK 834
                     |:||        .|..|.|           |::..:..|.|:      |::...:.
  Fly   904 SDSVFLKGFLKCQRFQIVKINQEQNLVKEEDRMRDIIFQLKQEVDGKKNLI------EEEKEVIN 962

  Fly   835 AVQARITHLNHILREKSDNLEEQPGPEQQETL----------RHEIRNLRGTRDLLLEERCHLDR 889
            .::|:||.||.|...|:.|.:.:...|:.:|.          ..|:..|:.:...|..:.|.|.:
  Fly   963 NLRAQITSLNQIETIKNQNAKTKILCEELQTKDTVQTANKQESQEVLTLKTSLAHLKSKVCELQK 1027

  Fly   890 KLKRDKVLTQKEERKLLECDEAIEAI-----------------------------DAAIEFKNEM 925
            ||::     |.|:.|:.|....|..|                             ::.:|.::..
  Fly  1028 KLEK-----QSEDEKISELQSDIGEISECCLSMELKLADIVNWQAEELRPLDQLQESGVELQHHS 1087

  Fly   926 ITGHRSIDTSDRIQR--------------EKGEQML------MARLNRLSTEEMRTLLYKYFTKV 970
            .|...|::....||.              |:.|:.|      ::.|.:..|:|.::|..:|..|:
  Fly  1088 TTAEESLNVEKPIQEQTERTLTTEYERRIEQLEESLQRAQEELSILEKRKTDENKSLQLEYMAKI 1152

  Fly   971 ---------------IDLRDSSRKLELQLVQLERERDAWEWK--------ERVLSNAVRQARLEG 1012
                           :||:::.::.|.||.|...:..:...:        :|.|...:.||  |.
  Fly  1153 ETSENENRSKFRAYCLDLKETQKRYEEQLQQTNEKLASVTTQCQVHLDVIKRSLQEKITQA--EK 1215

  Fly  1013 ERNAVLLQRQHEMKLTLMLRHMAEETSASSASYGER 1048
            |||.:.::.:.|      |..:.|......:||.|:
  Fly  1216 ERNELAVRHKAE------LEKIRETLKEKESSYKEK 1245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	66/295 (22%)
cos	NP_001260765.1	SPEC	657..856	CDD:295325	60/325 (18%)
cana	NP_001027247.1	KISc	8..316	CDD:214526	67/300 (22%)
		Motor_domain	8..310	CDD:277568	65/294 (22%)
		SMC_prok_B	<471..1270	CDD:274008	144/802 (18%)
		Mplasa_alph_rch	924..1647	CDD:275316	64/341 (19%)
		CENP-H	1204..>1266	CDD:283493	14/50 (28%)
		CALCOCO1	<1489..1850	CDD:285171
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437875
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930