DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cos and Klp59D

DIOPT Version :9

Sequence 1:	NP_001260765.1	Gene:	cos / 35653	FlyBaseID:	FBgn0000352	Length:	1201	Species:	Drosophila melanogaster
Sequence 2:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	126/563 - (22%)
Similarity:	188/563 - (33%)	Gaps:	170/563 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 DPNGNAEQDSAADSKTIPDANGNDSGQKDYPDSAYCVQAIPIS--------ASALGLPSALPGGD 119
            ||||...|....                       ||:..|:|        ...:.:|||
  Fly   225 DPNGGTVQQITV-----------------------CVRKRPMSRKEENSKNLDIITVPSA----- 261

  Fly   120 PMDSIAAGLIQ--------VGPHTVPVTHALPSSSSQEQVYHQTVFPLITLFLEGFDASVVTYGQ 176
              ||:....::        :..|.....:......|...||..|..|||....||.:|:...|||
  Fly   262 --DSLIVHELRLKVDLTKFLEHHKFRFDYTFDEECSNALVYDHTARPLIRTMFEGGNATCFAYGQ 324

  Fly   177 RGQGKSYTL----YGNVQDPTLTDSTEGVVQLCVRDIFSHISLHPERTY---AINVGFVEICGGD 234
            .|.||::|:    :|.||     |...|:..:..||:|..:| .||...   .|...|.||.|..
  Fly   325 TGSGKTHTMGGEFFGKVQ-----DCGTGIYAMAARDVFEEVS-RPEYRQMGAKITCSFFEIYGTK 383

  Fly   235 VCDLL--------------------GMGNIHCTNVDAVFHWLQVGLSAR---------QSLPAHT 270
            |.|||                    |:..:..|.|:.|...::.|...|         :|..:|.
  Fly   384 VFDLLLPNKPMLRVLEDARQQVVVVGLTEMPVTKVEDVLRLIEHGSKERTSGQTSANAKSSRSHA 448

  Fly   271 LFTLTLE--QQWVSKEGLLQHRLSTASFSDLCGTERCGD--------QPPGRPLDAGLCMLEQVI 325
            :|.:.|.  ..| ...|       ..||.||.|.||..|        :..|..::..|..|::.|
  Fly   449 VFQIALHFPDSW-GPHG-------KCSFVDLAGNERGADTQSADRQTRIEGAEINKSLLALKECI 505

  Fly   326 STLTDPGLMYGVNGNIPYGQTTLTTLLKDSF--GGRAQTLVILCVSPLEEHLPETLGNLQFAFKV 388
            ..|:..      :.::|:..:.||.:|:|||  |.:.:|.:|..:||....:..||..|::|.:|
  Fly   506 RALSRQ------SSHLPFRGSKLTQVLRDSFVGGKKNKTCMIAMISPSMSCVENTLNTLRYADRV 564

  Fly   389 -----------QCV----RNFVIMNTYSDDNTMIVQPAEPVPE---------SNSSAG------- 422
                       |.|    .....:|..|:...|..:..:..||         |:..|.
  Fly   565 KELIAKEDEHLQSVEGDGEKSPDLNEESEPEMMADEEGDEEPEDEDNQHLTISSEEASSYNNMSY 629

  Fly   423 ------PLSQAGPGDNFGLQFAASQWSKLVTNAEGLFSKLIDSKLITEVEKEQIEEWLFLKQECE 481
                  .|:..||..|..:|..|.|.:.||.|.|.........|...|:|:        ..|..|
  Fly   630 DMSFNHTLNILGPSRNVDIQEVAEQHALLVENLETYAHNFRQLKTDKEIEQ--------YTQNSE 686

  Fly   482 ECLSSTEAMRQQKQLVPILEAEEPEDVNSEAANSESPNSDNEN 524
            ..|....||           .....||.......:....:|:|
  Fly   687 SALMKLLAM-----------VNRTRDVTHNYNTQKLLKEENQN 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	80/315 (25%)
cos	NP_001260765.1	SPEC	657..856	CDD:295325
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	88/381 (23%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	87/353 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437788
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030