DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cos and Klp59C

DIOPT Version :9

Sequence 1:	NP_001260765.1	Gene:	cos / 35653	FlyBaseID:	FBgn0000352	Length:	1201	Species:	Drosophila melanogaster
Sequence 2:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	118/528 - (22%)
Similarity:	196/528 - (37%)	Gaps:	138/528 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EIPIQVAVRIFPHRELKDLLRSFG----------PTEPKKDAQAVDEGADSKDSEAQVPAAEKDN 56
            |:|:::.|.:.||  :.|..|..|          ...|:...|.:..|:.| ...|..|..::..
  Fly    49 ELPLELVVLMNPH--IFDSPRCSGGNAASANQTASISPRSMKQRIATGSLS-PVLATAPPRQQTA 110

  Fly    57 PSISETDPNGNA-------EQDSAADSKTIPD---ANGNDSG------------QKDYPDS---- 95
            |.:.|.:....|       |:...|.::|..|   ....|.|            |::..:|
  Fly   111 PPVREDEVVHQAERMRKERERRREAQARTRLDREQGKNEDPGNPNWEVARMIRLQREQMESQRVR 175

  Fly    96 -------------AYCVQAIPISASAL--------GLPS--ALPGGDPMDSIAAGLIQ-VGPHTV 136
                         ..||:..|:....|        .:||  .|...:|...:  .|:: :..|:.
  Fly   176 SGTTNERINCHQIMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEPRKHV--NLVKFLENHSF 238

  Fly   137 PVTHALPSSSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLTDST-EG 200
            ...:......|...||..|..|||....:|..|:...|||.|.||:||:.|  |.|....|: :|
  Fly   239 RFDYVFDEECSNATVYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGG--QFPGRHQSSMDG 301

  Fly   201 VVQLCVRDIFSHISLHPERTYAINV--GFVEICGGDVCDLL--------------------GMGN 243
            :..:..:|:||.:...|.....:.|  .|.||.|..|.|||                    |:..
  Fly   302 IYAMAAKDVFSTLKTVPYNKLNLKVYCSFFEIYGTRVFDLLMPGKPQLRVLEDRNQQVQVVGLTQ 366

  Fly   244 IHCTNVDAVFHWLQVGLSAR---------QSLPAHTLFTLTLEQQWVSKEGLLQHRLSTASFSDL 299
            ....|...|...|::|.|.|         :|..:|.:|.:.|.    |..|...|  ...|..||
  Fly   367 NPVQNTAEVLDLLELGNSVRTSGHTSANSKSSRSHAVFQIVLR----SAAGEKLH--GKFSLIDL 425

  Fly   300 CGTERCGDQP--------PGRPLDAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTTLTTLLKDSF 356
            .|.||..|..        .|..::..|.:|::.|..|...      :.::|:..:.||.:|:|||
  Fly   426 AGNERGADNSSADRQTRLEGSEINKSLLVLKECIRALGRQ------SSHLPFRGSKLTQVLRDSF 484

  Fly   357 --GGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTMIVQ--PAEPVPES 417
              |.:.:|.:|..:||....:..||..|::|.:|:               .:.|:  |::.:|::
  Fly   485 IGGKKVKTCMIAMISPCLHSVEHTLNTLRYADRVK---------------ELSVESIPSKRMPDA 534

  Fly   418 NSSAGPLS 425
            |..:..:|
  Fly   535 NLGSTSMS 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	78/298 (26%)
cos	NP_001260765.1	SPEC	657..856	CDD:295325
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	87/347 (25%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	86/357 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437789
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030