Protein Alignment cos and unc-104

DIOPT Version :9

• Sequence 1: NP_001260765.1
• Gene: cos / 35653
• FlyBaseID: FBgn0000352
• Length: 1201
• Species: Drosophila melanogaster
• Sequence 2: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Alignment Length: 1002
• Identity: 198/1002 - (19%)
• Similarity: 338/1002 - (33%)
• Gaps: 346/1002 - (34%)

  Fly   146 SSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLTDSTEGVVQLCVRDIF 210
            |:|..||......::....:|::..:..|||.|.|||||:.|..:     :..||::.:..:|:|
  Fly    68 STQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQE-----EQQEGIIPMICKDLF 127

  Fly   211 SHI--SLHPERTYAINVGFVEICGGDVCDLL---GMGNIH------------------CTNVDAV 252
            :.|  :...:..|::.|.::||....|.|||   ..||:.                  .|:...:
  Fly   128 TRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDI 192

  Fly   253 FHWLQVGLSAR---------QSLPAHTLFTLTLEQQWVSKEGLLQH----RLSTASFSDLCGTER 304
            ...:..|..||         .|..:|.:||:...|:   :..|:.:    ::|..|..||.|:||
  Fly   193 HDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQR---RHDLMTNLTTEKVSKISLVDLAGSER 254

  Fly   305 CGDQ-------PPGRPLDAGLCMLEQVISTLTDPGLMYGVNGN------IPYGQTTLTTLLKDSF 356
            ....       ..|..::..|..|.:|||.|.:   :.....|      |||..:.||.||:::.
  Fly   255 ADSTGAKGTRLKEGANINKSLTTLGKVISALAE---VASKKKNTKKADFIPYRDSALTWLLRENL 316

  Fly   357 GGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTMIVQPAEPVPESNSSA 421
            ||.::|.:|..:||.:.:..|||..|:                |:|....||
  Fly   317 GGNSKTAMIAAISPADINYDETLSTLR----------------YADRAKQIV------------- 352

  Fly   422 GPLSQAGPGDNFGLQFAASQWSKLVTNAEGLFSKLIDSKLITEVEKEQIEEWLFLKQECEECLSS 486
                                 .|.|.|.:.      ::|||.|: ||:|:
  Fly   353 ---------------------CKAVVNEDA------NAKLIREL-KEEIQ--------------- 374

  Fly   487 TEAMRQQKQLVPILEAE----EPEDVNSEAANSESP-NSDNENDTDNESHRPDLDDKIESLMEEF 546
                    :|..:|:||    :.||..:::...:|| .|.|.|.:..|.....|... |.|:.|.
  Fly   375 --------KLRDLLKAEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQAS-EKLIAEL 430

  Fly   547 RDKTDALILEKHAEYLSKHPKAVMQSQDREIEAQPPEENGDDRKVSIGSRRRSVQPGASLSTAEL 611
            .:..:..:  |..|.:....:||.......::.       |...|.:.|.::         |..|
  Fly   431 NETWEEKL--KRTEEIRVQREAVFAEMGVAVKE-------DGITVGVFSPKK---------TPHL 477

  Fly   612 AMLNRVASQQPPPPIDPESVVDPLESSSGEGIRQAALAAAAATAPIEQLQKKLRKLVAEIEGKQR 676
            ..||.          || ::.:.|.....||:.:.....|.....|:.....:.|.....|.|
  Fly   478 VNLNE----------DP-NLSECLLYYIKEGLTRLGTHEANVPQDIQLSGSHILKEHCTFENK-- 529

  Fly   677 QLREIEETIQVKQNIIAELVKNSDTRSHAKQRFHKKRAKL-EAECDKAKKQLGKALVQGRDQSEI 740
                         |....|:.:.|...:...|      || |.|..|.    |..::.|:  :.:
  Fly   530 -------------NSTVTLLPHKDAIIYVNGR------KLVEPEVLKT----GSRVILGK--NHV 569

  Fly   741 ERWTTIIGHLERRLEDLSSMKHIAGESGQKVKKLQQSVGESRKQADDLQKKLRKECKLRCQMEAE 805
            .|:|                      :.::.::|:..: |:..:|::..:|...:     |::..
  Fly   570 FRFT----------------------NPEQARELRDKI-ETENEAENEVEKTDTQ-----QVDWN 606

  Fly   806 LAKLRESRETGKELVKAQGSPEQQGRQLKAVQARITHLNHILREKSDNLEEQPGPEQQETLRHEI 870
            .|:.        ||:      |:||..|||.          ::::.||||||
  Fly   607 FAQC--------ELL------EKQGIDLKAE----------MKKRLDNLEEQ------------- 634

  Fly   871 RNLRGTRDLLLEERCHLDRKLKRDKVLTQ---KEERKLLECDEAIEAIDAAIEFKNEMITGHRSI 932
                                .||:|:...   :|:||..|.  .|:|:...:|.::..::.:.|.
  Fly   635 --------------------YKREKLQADQQFEEQRKTYEA--RIDALQKQVEEQSMTMSMYSSY 677

  Fly   933 DTSDRIQRE------KGEQMLMARLNRLSTEEMRTLLYKYFTKVIDLRDSSRKLELQLVQLERER 991
            ...|..|.|      ..|....||...|:....|...|..||   .|||
  Fly   678 SPEDFHQEEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQFT---SLRD---------------- 723

  Fly   992 DAWEWKERVLSNAVRQARLEGERNAVLLQRQHEMKLTLMLRHMAEETSASSASYGERALAPACVA 1056
            |.|                   .||:.|:..:.:.:.|..:...:.|..:...|.......|...
  Fly   724 DLW-------------------GNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTV 769

  Fly  1057 PPVQASSDFDYDHFYKGGGNP-SKALI 1082
            .||....:|        |..| ||.|:
  Fly   770 APVHQEDEF--------GAPPVSKTLV 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	72/291 (25%)
		SPEC	657..856	CDD:295325	34/199 (17%)
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	78/350 (22%)
		KISc	3..358	CDD:214526	78/350 (22%)
		Kinesin_assoc	355..498	CDD:292801	40/202 (20%)
		FHA	475..574	CDD:238017	26/158 (16%)
		KIF1B	878..923	CDD:289208
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437865
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030