Protein Alignment cos and Khc

DIOPT Version :9

• Sequence 1: NP_001260765.1
• Gene: cos / 35653
• FlyBaseID: FBgn0000352
• Length: 1201
• Species: Drosophila melanogaster
• Sequence 2: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Alignment Length: 992
• Identity: 218/992 - (21%)
• Similarity: 396/992 - (39%)
• Gaps: 234/992 - (23%)

  Fly   145 SSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLTDSTEGVVQLCVRDI 209
            ::|||:||::....::|..|.|::.::..|||...||::|:.|.:.|..    .:|::...|.||
  Fly    62 NASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSV----KQGIIPRIVNDI 122

  Fly   210 FSHI-SLHPERTYAINVGFVEICGGDVCDLLGMGNIH--------------------CTNVDAVF 253
            |:|| ::.....:.|.|.:.||....:.|||.:..::                    .::.:.||
  Fly   123 FNHIYAMEVNLEFHIKVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVF 187

  Fly   254 HWLQVGLSAR---------QSLPAHTLFTLTLEQQWVSKEGLLQHRLSTASFSDLCGTERCG--- 306
            ..::.|.|.|         .|..:|::|.:.::|:.:..:..|..:|...   ||.|:|:..
  Fly   188 EVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLV---DLAGSEKVSKTG 249

  Fly   307 ------DQPPGRPLDAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTTLTTLLKDSFGGRAQTLVI 365
                  |:  .:.::..|..|..|||.|.|     |...:|||..:.||.:|::|.||.|:|.::
  Fly   250 AEGTVLDE--AKNINKSLSALGNVISALAD-----GNKTHIPYRDSKLTRILQESLGGNARTTIV 307

  Fly   366 LCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTMIVQPAEPVPESNSSAGPLSQAGPG 430
            :|.||...:..||...|.|..:.:.|:|.|.:|.
  Fly   308 ICCSPASFNESETKSTLDFGRRAKTVKNVVCVNE------------------------------- 341

  Fly   431 DNFGLQFAASQWSKLVTNAEGLFSKLIDSKLITEVEKEQIE--EWLFLKQECEECLSSTEAMRQQ 493
                 :..|.:|.:....     .|..:::|..:|||.:||  .|     ...|.:.:.|.:..:
  Fly   342 -----ELTAEEWKRRYEK-----EKEKNARLKGKVEKLEIELARW-----RAGETVKAEEQINME 391

  Fly   494 KQL---VPILEAEEPEDVNSEA---------ANSESPNSDNEN---DTDNESHRPDLDDKIESLM 543
            ..:   .|.||.|..:...:||         ||..:..:.||.   .|:.|.....||||.|.:.
  Fly   392 DLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDKDEEIN 456

  Fly   544 EEFRDKTDALILEKHAEYLSKHPKAVMQSQDREIEAQPPEENGDDRKVSIGSRRRSVQPGASLST 608
            ::          .::||.|.:.   ||:.::                 .|.:.||..:...|
  Fly   457 QQ----------SQYAEQLKEQ---VMEQEE-----------------LIANARREYETLQS--- 488

  Fly   609 AELAMLNRVASQQPPPPIDPESVVDPLESSSGEGIRQAALAAAAATAPIEQLQKKLRKLVAEIEG 673
             |:|.:     ||.             ..|:.|.:::...|       :|:|.....:...||:.
  Fly   489 -EMARI-----QQE-------------NESAKEEVKEVLQA-------LEELAVNYDQKSQEIDN 527

  Fly   674 KQRQLREIEETIQVKQNII----AELVKNSDTRSHAKQRFHKKRAKLEAECDKAKKQLGKALVQG 734
            |.:.:..:.|.:|.||::.    .||.:..|..||.|:|..:....|..:..    ::|:|:..|
  Fly   528 KNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLG----EVGQAIAPG 588

  Fly   735 RDQSEIERWTTIIGHLERRLED--------LSSMKHIAGESGQKVKKLQQSVGESRKQADDLQKK 791
            ....:: :.:.:.|....::|:        :|.||..|....|:...::....:|.|:..:.:|.
  Fly   589 ESSIDL-KMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKD 652

  Fly   792 LRKECKLRCQMEAELAKLRES---RETGKELVKAQ-GSPEQQGRQLKAVQARITHLNHILREKSD 852
            |.:...|..|.||.:..|:||   .|..|..::.| .|..::..:|||.: .::.:|...:::::
  Fly   653 LGEYRLLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAE-HVSAVNAEEKQRAE 716

  Fly   853 NLEEQPGPEQQETLRHEIRNLRGTRDLLLEERCHLDR-KLKRDKVLTQKEERKLLECD-EAIEAI 915
            .|......:..|......|.:...||.:..::..:|. |....|:|...::   :..| |.:...
  Fly   717 ELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQ---MTADYEKVRQE 778

  Fly   916 DA--AIEFKNEMITGHRSIDTSDRIQREKGEQMLMARLNRLSTEEMRTL--LYKYFTKVIDLRDS 976
            ||  :.|.:|.::|..|         ||:..:.|.. |.....:|::||  |.|.|  |.||:..
  Fly   779 DAEKSSELQNIILTNER---------REQARKDLKG-LEDTVAKELQTLHNLRKLF--VQDLQQR 831

  Fly   977 SRKLELQLVQLERERD----AWEWKERVLSNAVRQ--------ARLEGERNAVLLQRQHEMKLTL 1029
            .||   .:|..|.|.|    |.:.|...|.|.:.|        .|...:....|.:.:..::.|
  Fly   832 IRK---NVVNEESEEDGGSLAQKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCT- 892

  Fly  1030 MLRHMAEETSASSASYG 1046
            |.|..|.||:...|..|
  Fly   893 MERVKALETALKEAKEG 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	72/282 (26%)
		SPEC	657..856	CDD:295325	47/214 (22%)
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	72/284 (25%)
		KISc	12..340	CDD:214526	75/291 (26%)
		Apolipoprotein	595..744	CDD:279749	31/149 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437870
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030