DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cos and Khc-73

DIOPT Version :9

Sequence 1:	NP_001260765.1	Gene:	cos / 35653	FlyBaseID:	FBgn0000352	Length:	1201	Species:	Drosophila melanogaster
Sequence 2:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster

Alignment Length:	1423	Identity:	271/1423 - (19%)
Similarity:	478/1423 - (33%)	Gaps:	472/1423 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 PHTVPVTHALPSSSSQEQVY--HQTVFP-----LITLFLEGFDASVVTYGQRGQGKSYTLYGNVQ 190
            |.|....|...|.:.:::.:  .:|||.     ::....:|::|.:..|||.|.|||||:.|
  Fly    51 PKTFAFDHCFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMG--- 112

  Fly   191 DPTLTDSTEGVVQLCVRDIFSHIS--LHPERTYAINVGFVEICGGDVCDLL-------------- 239
                |..::|::......:||.|:  ..||..|.:.|.::||....|.|||
  Fly   113 ----TQESKGIIPRLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREH 173

  Fly   240 --------GMGNIHCTNVDAVFHWLQVGLSAR---------QSLPAHTLFTLTLEQQWVSK-EGL 286
                    |:..:..|:...:.:.:..|..:|         :|..:|.:|::.|.|....: .|:
  Fly   174 NVMGPYVDGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGV 238

  Fly   287 LQHRLSTASFSDLCGTERC------GDQ-PPGRPLDAGLCMLEQVISTLTDP--GLMYGVNGNIP 342
            ...::|..|..||.|:||.      ||: ..|..::..|..|..|||.|.|.  |...|.:..:|
  Fly   239 SGEKVSRMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVP 303

  Fly   343 YGQTTLTTLLKDSFGGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTMI 407
            |..:.||.||||:.||.::|:::..:||..::..|||..|::|.:.:.:.|..::|  .|.|..|
  Fly   304 YRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVN--EDPNARI 366

  Fly   408 VQPAEPVPESNSSAGPLSQAGPGDNFGLQFAASQWSKLVTNAEGLFSKLIDSKLITEVEKEQIEE 472
            ::......|:..|....:...|..:...:.|.|:      |.....|:..:.||: :.|:.|.|.
  Fly   367 IRELRHEVETLRSMLKHATGSPVGDVQDKLAESE------NLMKQISQTWEEKLV-KTERIQNER 424

  Fly   473 WLFLKQECEECLSSTEA----MRQQKQLVPILEAE------------------------------ 503
                :|..|:...|.:|    :.:.|..:..|.|:
  Fly   425 ----QQALEKMGISVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQ 485

  Fly   504 ------EPED---------------------VNSEAANSESP-----------------NSDNEN 524
                  :||.                     ||..||..::|                 ||...|
  Fly   486 LSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSN 550

  Fly   525 DTDNESHRPDLDDKIESLMEEFRDKTDALILEKHAEYLSKHPKAVMQSQDREIEAQPPEENGDDR 589
            :|...:..|    :..:.:.::....|.::..:    ||..|   :|:....:|.|..|    |:
  Fly   551 NTSMCASEP----QTPAQLIDYNFARDEIMQNE----LSNDP---IQTAIARLERQHEE----DK 600

  Fly   590 KVSIGSRRRSVQPGASLSTAELAMLNRVASQQPPPPIDPESVVDPL------------------- 635
            :|::..:|:..:       .:...|..:.|  |..|..|.:..|||
  Fly   601 QVALEKQRQEYE-------RQFQQLRNILS--PSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKW 656

  Fly   636 --------ESSSGE---GIRQAALAAAAATAPIEQLQKKLRKLV------AEIEGKQRQLREIEE 683
                    ..|.|:   .|.:|......|....|:::||.:..|      |.:...:|:...:.|
  Fly   657 AQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSE 721

  Fly   684 -TIQVK------QNIIAELVKNS--DTRSHAKQRFHKKRAKLEAECDKAKKQ------------L 727
             .|.||      |....|.::|.  |.|...::  ||:|.....:.|.||.|            :
  Fly   722 PAILVKRTNSGSQIWTMEKLENKLIDMREMYQE--HKERVLNGLDEDNAKPQDPFYESQENHNLI 784

  Fly   728 GKA------------------------LVQGRDQSEIERWTTIIGHLERRLEDLSSMKHIAGESG 768
            |.|                        .|.||.|.||||                    |||:..
  Fly   785 GVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIER--------------------IAGQMP 829

  Fly   769 Q--KVKKLQQSVGESRKQADD----LQKKLRKECKLRCQMEAELA---------KLRESRETGKE 818
            |  ..:.:.:|.|:||.:.||    ...::.....::|.....|:         .....:|....
  Fly   830 QDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVP 894

  Fly   819 LVKAQGSPEQQGRQLK-------AVQARITHLNHILREKSDNLEEQPGPEQQETLRHEIRNLRGT 876
            ::.|:.:...|....|       .|......|.|.:.          |....|...|.......|
  Fly   895 VINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIE----------GALSIEVWGHRSAGFSKT 949

  Fly   877 RDLLLEERCHLDRKL-KRDKVLTQKEER--KLLECDEAIEAIDAAIEFKNEMITG---------H 929
            :...:|::....|.| .|...|::|.|.  ::.|.::..|.....:..:||::||         .
  Fly   950 KGWEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQ 1014

  Fly   930 RSIDTSDRIQREKGEQMLM---------------ARLNR-LST--EEMRTLLYKYFTKVIDLRDS 976
            |.::...:..:..|...::               :||.| |.:  ||..|:|.:.:::.:..|..
  Fly  1015 RRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLTVLREKWSEALGRRRQ 1079

  Fly   977 SRKLELQLVQLERERDAWEWKERVLSNAVRQARLEGERNAVL----------------------- 1018
            ....::|::..:.|::..| :||.||...:...|..||||||
  Fly  1080 YLDQQIQMLIKKEEKNEQE-RERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEP 1143

  Fly  1019 -------------------------------LQRQHEMKL-TL-MLRHMAEETSASSASYGERAL 1050
                                           |.::|..|. || :|:|:.::.
  Fly  1144 HVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHKFYTLQILQHLDKDV------------ 1196

  Fly  1051 APACVAPPVQASSDFDYDHFYKGGGNPSKAL-------------------IKAPKPM-------- 1088
              .|||.             :....:.|:||                   :..|.||
  Fly  1197 --CCVAS-------------WDSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRL 1246

  Fly  1089 ----PTGSAL-DKYKDKEQRSGRNIF----AKFHVLTRYASAA------------AAGSSGSTAE 1132
                ..|..| |:.|......|.|..    ..:.|::....|:            ||.....:|.
  Fly  1247 SINIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGDDCSAS 1311

  Fly  1133 ESTALIESTTTATATTTSTTTTGAVGK---VKDKALVSFRPEQLKRLMPAPTATKVTR 1187
            :....||..|...:...|..|...:.:   ||:......:|..:::.:..|..:::.|
  Fly  1312 DGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQIMR 1369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	81/305 (27%)
cos	NP_001260765.1	SPEC	657..856	CDD:295325	51/271 (19%)
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	82/314 (26%)
		KISc	6..359	CDD:214526	82/314 (26%)
		Kinesin_assoc	356..468	CDD:292801	23/124 (19%)
		FHA	446..546	CDD:238017	10/99 (10%)
		KIF1B	741..786	CDD:289208	10/46 (22%)
		DUF3694	<1196..1252	CDD:289256	9/82 (11%)
		CAP_GLY	1786..1850	CDD:279625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437745
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030