DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cos and neb

DIOPT Version :9

Sequence 1:	NP_001260765.1	Gene:	cos / 35653	FlyBaseID:	FBgn0000352	Length:	1201	Species:	Drosophila melanogaster
Sequence 2:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster

Alignment Length:	1343	Identity:	267/1343 - (19%)
Similarity:	442/1343 - (32%)	Gaps:	475/1343 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 HRELKDLLRS---FGPT-EPKKDAQAVD---------EGADSKDSEAQVPAAEKDNPSISETDPN 65
            ||:..:.|.:   .|.| :||....|::         ..|:|....|:.|...|.  |.|.|
  Fly    43 HRDRPEQLLNTAFSGSTPQPKPKPTALNACYTPSSLYRNANSTPGRAKTPGTGKS--SCSRT--- 102

  Fly    66 GNAEQDSAADSKTIPDANGNDSGQKDYPDSAYCVQAIPISA------------SALGLPSAL--P 116
              .|:||..:|........|         ....|:..|::|            ...|..:.|  .
  Fly   103 --KERDSLMESCLSVSEESN---------MIVAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQ 156

  Fly   117 GGDPMDSIAAGLIQVGPHTVPVTHALPSSSSQEQVYHQ-----------------TVFPLITLFL 164
            .|...|:.|.           |||..    |.:|||:.                 |..|||....
  Fly   157 AGSSADASAG-----------VTHFF----SYDQVYYSCDPERKNFACQAKVFEGTARPLIDTAF 206

  Fly   165 EGFDASVVTYGQRGQGKSYTLYG-NVQDPTLTD-----STEGVVQLCVRDIFSHISL---HPERT 220
            ||::|.:..|||.|.||||::.| ...|....|     ...|::.....::|..|..   ..:..
  Fly   207 EGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQ 271

  Fly   221 YAINVGFVEICGGDVCDLLGMG------------------------------------NIHCTNV 249
            ..:.|.:.||....:.|||.:.                                    ::...:|
  Fly   272 VEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSV 336

  Fly   250 D---AVFHWLQVGLSAR---------QSLPAHTLFTLTLEQQWVSKE-------------GLLQH 289
            |   |:.:||.||.|.|         :|..:|::|.:.|....:|.:             .|.|.
  Fly   337 DSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQT 401

  Fly   290 RLSTASFSDLCGTERC------GDQ-PPGRPLDAGLCMLEQVISTLTD--PGLMYGVNGN----- 340
            |.|..|..||.|:||.      |:: ..|..::..|..|.:||:.|.|  ..:..|..|:
  Fly   402 RRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVIAALADSRKAIANGPLGSGTPST 466

  Fly   341 -IPYGQTTLTTLLKDSFGGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDN 404
             :||.::.||.||:::.||.::|:::..:||...|..|||..|::|.|.:.:.|.|.:|....|.
  Fly   467 FVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLRYACKARSIVNRVKVNESPHDK 531

  Fly   405 TMIVQPAEPVPESNSSAGPLSQAGPGDNFGLQFAASQWSKLVTNAEGLFSKLIDSKLITEVEKEQ 469
            .:....|| |....|               |:....:..:|..|:    :..:..|:|.|...::
  Fly   532 IIRDLRAE-VDRLKS---------------LRNEYERQRRLSGNS----NNPVPRKIIIETSVDE 576

  Fly   470 IEEWLFLKQECEECLSSTEAMRQQKQLVPILEAEEPEDVNSEAANSESPNSDNENDTDNESHRPD 534
            .|               .||:|||     :.|.|.                             :
  Fly   577 TE---------------VEALRQQ-----LAERER-----------------------------E 592

  Fly   535 LDDKIESLMEEFRD-----KTDALILEKHA---EYLSKHPKAVMQSQDREIEAQP---------- 581
            |....:|.||:.::     |::..:|::..   |..::..:|.:.:    :.|.|
  Fly   593 LSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALELTAEQKQACLVN----LTADPILSGTLFYLL 653

  Fly   582 PEENGDDRKVSIGSRRRSVQPGASLSTAELAMLNRVASQQPPPPIDPESVVDPLESSSGEGIRQA 646
            |:     ..|.||   |...||.|.|:                  .|:.|:|
  Fly   654 PQ-----GLVRIG---RGRLPGGSSSS------------------QPDIVLD------------- 679

  Fly   647 ALAAAAATAPIEQLQKKLRKLVAEIEGKQ-RQLREIEETIQVKQNIIAELVKNSDTRSHAKQRFH 710
                    .|:..||.      ..||.:: .:|..|..:...:..:..||:|:      .:|.||
  Fly   680 --------GPLVALQH------CSIEHERGGKLYVIPGSEDFETYVNGELLKD------RRQLFH 724

  Fly   711 KKRAKLEAE---------CDKAKKQLGKA------------LVQGRDQ---SEIERWTTIIGHLE 751
            ..|..:...         |    .|.|||            ::|.::|   ||:|
  Fly   725 GDRLVIGGSHYFRISNPFC----SQRGKADHPVDFQLAHQEILQKQEQQLRSELE---------- 775

  Fly   752 RRLEDLSSMKHIAGESGQKVKKLQQSVGESRKQADDLQKKLR----KECKLRCQMEAELAKLRES 812
                         .|....:.|::|   |..:.|.|.:::|:    ::.|.:|.        .|.
  Fly   776 -------------AEKRAALTKIEQ---ERAQHARDFEERLQCLELEQFKYKCN--------SEM 816

  Fly   813 RETGKELVKAQGSPEQQGRQLKAVQARITHLNHILREKSDNLEEQPGPEQQETLRHEIRNLRGTR 877
            .||           |:|...| |.|...|.|.|     .|.:..   |.|:.|:..:|:.
  Fly   817 LET-----------ERQALAL-AQQQEHTPLRH-----EDAVST---PAQKSTILEDIQR----- 856

  Fly   878 DLLL---EERCHLDRKLKRDKVLTQKEERKLLECDEAIEAIDAAIEFKNEMITGHRSIDTSDRIQ 939
             ::|   ||..|             |.:..:.|..:....:|..:||        |...|.|...
  Fly   857 -IMLNPSEESLH-------------KTQLMVKEATQRCRQLDLPLEF--------RQTQTPDEFG 899

  Fly   940 REKGEQMLMARLNRLSTEEMRTLLYKYFTKVIDLRDSSRKLELQLVQLERERDAWEWKERVLSNA 1004
            ..:...:::.:...|..|.....|..:...|.|..:...||....:....|.| ||..:..|:..
  Fly   900 LLRTVILILDKQRGLKAEWPTARLGVWLDLVRDNAEQQEKLNATTIFQSVEVD-WEPLDADLNET 963

  Fly  1005 VRQARLEGERNAVLLQRQHEMKLTLMLRHMAEETSASSASYGERALAPACVAPPVQASSDFDYDH 1069
            :.... ...|.|:.|....::.|...|:.:...:|:.|.:       |...:.|...|   ...|
  Fly   964 LSDTH-NSSRIALNLSAMKDVLLNKPLKRLLNASSSKSNT-------PRQTSTPSPGS---QLVH 1017

  Fly  1070 FYKGGGNPSKALIKAPKPMP-TGSALDKYKDKE----QRSGRNIFAKFHVLTRYASAAAA----- 1124
            |.|      :.|...|:.:| :.|:......:|    |||.:.       |.|:..||..
  Fly  1018 FTK------RLLTYDPEEIPESQSSFTTLVQQELQIMQRSAQR-------LRRHCEAALLERENH 1069

  Fly  1125 ---GSSGSTAEESTALIEST----------TTATATTTSTTTT 1154
               |....:.:|:.|.:::.          ..|||..||.|.|
  Fly  1070 QDNGVLAVSLQEALARMDTVLNGMHTSLARAEATACVTSPTKT 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	86/358 (24%)
cos	NP_001260765.1	SPEC	657..856	CDD:295325	44/227 (19%)
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	97/429 (23%)
		KISc	120..525	CDD:214526	97/428 (23%)
		Kinesin_assoc	524..657	CDD:292801	31/210 (15%)
		FHA	634..740	CDD:238017	29/168 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437871
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030