DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cos and Klp3A

DIOPT Version :9

Sequence 1:	NP_001260765.1	Gene:	cos / 35653	FlyBaseID:	FBgn0000352	Length:	1201	Species:	Drosophila melanogaster
Sequence 2:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster

Alignment Length:	1144	Identity:	258/1144 - (22%)
Similarity:	442/1144 - (38%)	Gaps:	284/1144 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 SQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLTDSTEGVVQLCVRDIFS 211
            ||:.::...|...:...|.|::.:::.|||.|.||:||: |...:..|.|.. ||:...|.|||:
  Fly    60 SQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTM-GTAFNGVLDDHV-GVIPRAVHDIFT 122

  Fly   212 HIS-LHPERTYAINVGFVEICGGDVCDLL----------------------GMGNIHCTNVDAVF 253
            .|: :..|..:|:...|||:......||.                      |:..:..|:...|.
  Fly   123 AIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMPGLTELVVTSAQQVT 187

  Fly   254 HWLQVGLSAR---------QSLPAHTLFTLTLEQQWVSKEGLLQHRLSTASFS--DLCGTERC-- 305
            ..|..|.:.|         .|..:|.:|||||..  ...:|  :..::|:.|:  ||.|:|||
  Fly   188 DHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVA--TKLDG--KQSVTTSRFNLVDLAGSERCSK 248

  Fly   306 ----GDQ-PPGRPLDAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTTLTTLLKDSFGGRAQTLVI 365
                ||: ..|..::.||..|..||:.|...    ...|.|||.|:.||.||:||.||.:.||:|
  Fly   249 TLASGDRFKEGVNINKGLLALGNVINALGSG----QAAGYIPYRQSKLTRLLQDSLGGNSITLMI 309

  Fly   366 LCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMN--TYSDDNTMIVQPAEPVPESNSSAGPLSQAG 428
            .||||.:.::.|||..|::|.:...::|..::|  .::.:..|:....:.:.....|.|.:|
  Fly   310 ACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMS--- 371

  Fly   429 PGDNFGLQFAASQWSKLVT--NAEGLFSKLIDSKLITEVEKEQIEEWLFLKQECEECLSSTEA-- 489
                          |.|::  .|.||.:                       ..|||.|:.:.|
  Fly   372 --------------SSLISAVGAAGLGA-----------------------IPCEESLAGSMANA 399

  Fly   490 --MRQQKQLVPILEAEEPEDVNSEAANSESPNSDNENDTDNESHRPDLDDKIESLMEEFRDKTDA 552
              :::.|:.|..|:                   |.......|.|        :||::....:..|
  Fly   400 AEIQRLKEQVRTLQ-------------------DRNRKLQQELH--------QSLLDLTEKEMRA 437

  Fly   553 LILEKHAEYLSKHPKAVMQSQDREIEAQPPEE--NGDD--RKVSIGSRRRSVQPGASLSTAELAM 613
            .|.|:..:.|..|...:....|:..:||...|  |||:  |..|:                   :
  Fly   438 HIAEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSL-------------------L 483

  Fly   614 LNRVASQQPPPPIDPESVVDPLESSSGEGIRQAALAAAAATAPIE----QLQKKLRKLVAEIEGK 674
            :|||       .::.:...:.|||...|. || .|::.:.|...|    ::.:.|.....|...|
  Fly   484 VNRV-------HVELQRTQEELESQGHES-RQ-RLSSRSHTEGGESGGDEVHEMLHSHSEEYTNK 539

  Fly   675 QR----QLREIEETIQVKQNIIAELVKN-----SDTRSHAKQRFHKKRAKLEAE----CDKAK-- 724
            |.    :||.|...:.:||.:...:::|     ||......:..::|...||||    .|:.:
  Fly   540 QMNFAGELRNINRQLDLKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNI 604

  Fly   725 --KQLGKALVQGRDQSEIERWTTIIGHLERRLEDLSSMKHIAGESGQKVKKLQQSVGESRKQADD 787
              |.:...|.:.| :..::.....|..|.|:|...:::..|..:..:|::.|...:...::....
  Fly   605 KSKDISAKLAEER-RKRLQLLEQEISDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVK 668

  Fly   788 LQKKLRKEC----KLRCQMEAELAKLR-ESRETGKELVKAQGSPEQQGRQLKAVQARITHLNHIL 847
            |.:.:|.|.    :.:...|.||.:|: :.|:...|:|:.|....:|.:.||.........|..|
  Fly   669 LIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRL 733

  Fly   848 REKSDNLEEQPGPEQQETLRHEIRNLRGT----------------RDL---------------LL 881
            :   |.||.|...:.|   ||:.::..|:                |:|               |:
  Fly   734 K---DALERQASAQAQ---RHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSLIDAEHSLEQLM 792

  Fly   882 EERC------HLDRKLKRDKVLTQKEERKLLECDEAIEAIDAAIEFKNEMITGHRS----IDTSD 936
            |:|.      ||.::.|........|:.::|      .:::..:|.:|..|:..:.    .|...
  Fly   793 EDRAVINNHYHLLQQEKTSDPAEAAEQARIL------ASLEEELEMRNAQISDLQQKVCPTDLDS 851

  Fly   937 RIQ------------REKGEQML-----MARLNRLSTEEMRTLLYKYFTKVIDLR---DSSRKLE 981
            ||:            |...:|:|     ..||...|..|.||.|.:...:::|.:   |::.| .
  Fly   852 RIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTTLDELRAQLLDAQQQEDAASK-R 915

  Fly   982 LQLVQLERERD------AWEWKERVLSNAVRQARLEGERNAVLLQRQHEMKLTLMLRH-MAEETS 1039
            |:|:|.:.|..      |:|.|..||.....|...|....|...||...::..|..|. :.:|..
  Fly   916 LRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQRWAEARSPAEDQQRNQILEELLSSREALQQELD 980

  Fly  1040 ASSASYGERALAPACVAPPVQASSDFDYDHFYKGGGNPSKALIKA---PKPMPTGSALDKYKDKE 1101
            ...|.  .::.:.|..:.|    .|.| |.|....||.:..|...   |..:|:.|     |.|.
  Fly   981 KLRAK--NKSKSKAVKSEP----QDLD-DSFQIVDGNETVVLSDVSDDPDWVPSTS-----KSKR 1033

  Fly  1102 -QRSGRNIFAKFHVLTRYASAAAAGSSGSTAEESTALIE 1139
             |...||:.:...  .:.|:..:.|:|...:..||:..|
  Fly  1034 IQSDSRNVISPPE--KQDANVTSLGNSSIQSLNSTSATE 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	86/282 (30%)
cos	NP_001260765.1	SPEC	657..856	CDD:295325	47/224 (21%)
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	86/285 (30%)
		Kinesin	14..335	CDD:278646	86/284 (30%)
		Smc	<396..>994	CDD:224117	135/668 (20%)
		FlaC	522..633	CDD:225888	23/111 (21%)
		TCR	1075..1110	CDD:281618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437869
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930