DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cos and Kif27

DIOPT Version :9

Sequence 1:	NP_001260765.1	Gene:	cos / 35653	FlyBaseID:	FBgn0000352	Length:	1201	Species:	Drosophila melanogaster
Sequence 2:	NP_932167.1	Gene:	Kif27 / 246209	RGDID:	621071	Length:	1394	Species:	Rattus norvegicus

Alignment Length:	1320	Identity:	297/1320 - (22%)
Similarity:	513/1320 - (38%)	Gaps:	423/1320 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 SSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLTDSTEGVVQLCVRDI 209
            :|:|::||...:.||:...:||::|:|..|||.|.||:||: |.....::.|..:|::...:::|
  Rat    54 NSTQDEVYSTCIKPLVLSLIEGYNATVFAYGQTGSGKTYTI-GGGHVASVVDGQKGIIPRAIQEI 117

  Fly   210 FSHISLHPERTYAINVGFVEICGGDVCDLL----GMGNIH----------------C--TNVDAV 252
            |..||.:|...:.|.|.::|:...|:.|||    .|.::|                |  .:|:.|
  Rat   118 FQSISGNPNIDFKIKVSYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVIVGAKECQVDSVEDV 182

  Fly   253 FHWLQVGLSAR---------QSLPAHTLFTLTLEQ-----------QWVSKEGLLQHRLSTASFS 297
            ...||||.:||         .|..:|.:||:::.|           :|.|.    :|.:|...|.
  Rat   183 MGLLQVGNAARHTGTTQMNEHSSRSHAIFTISVCQVGKSAEATEDGEWCSH----RHIVSKFHFV 243

  Fly   298 DLCGTER------CGDQ-PPGRPLDAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTTLTTLLKDS 355
            ||.|:||      .|:: .....:::||..|..|||.|.||...   :.::||....:|.|||||
  Rat   244 DLAGSERVTKTGNTGERFKESIQINSGLLALGNVISALGDPRRK---SSHVPYRDAKITRLLKDS 305

  Fly   356 FGGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTM------IVQPAEPV 414
            .||.|:|::|.||||......|:|.:|::|.:.:.:||...:|.....:.|      |....|.:
  Rat   306 LGGSAKTVMITCVSPSSSDFDESLNSLKYANRARNIRNKPTLNFSPQADRMDEMEFEIKLLREAL 370

  Fly   415 PESNSSAGPLSQAG----PGDN---------FGLQFAASQWSKLVTNAEGLFSKLIDSKLITEVE 466
            ....:|....||..    |..|         ..||.....:...:..|......|.|:..:.:.:
  Rat   371 QSHQASISQTSQTASENVPDQNRIHSLEEQIAQLQEECLGYQDCIEQAFAFLVDLKDAVRLNQKQ 435

  Fly   467 KEQIEEW---------------------------------LFLKQECE--ECLSST--------- 487
            :.::::|                                 |.||:|.:  :|..:.
  Rat   436 QHKLQQWFSRTQEVRKAVLTPLPGNQSIGNLEEGPQHVTVLQLKRELKKYQCALAADQVVFTQKE 500

  Fly   488 ---EAMRQQKQL---------VPILEAEEPEDVNSE-----------------AANSESPNSDNE 523
               |.:|:|.||         |.:.||::...:.:|                 ..:|..|.|..|
  Rat   501 LELEELRRQMQLMAQESKGHAVSLKEAQKVNRLQNEKIIEQQLLVDQLSEELAKRSSSMPTSTKE 565

  Fly   524 NDTDNESHR---------------------PDLDD-----------KIESLMEEFRDKTDALI-- 554
            :..|....|                     |...|           .::.:...||.::..|:
  Rat   566 SCGDGPDARAPEKRPHTAPFDSHWGHYVYIPSRQDFKKVCSSSPVYSLDQVFAGFRTRSQMLMGH 630

  Fly   555 LEKHAEYLSKHPKAVMQSQDREIEAQPPEENGDDRKVSIGSRRRS--VQPGASLSTAELAMLNRV 617
            ||...|.|  |.:....|.|.:.|.|        .|..:.||..|  .:||:..|..|::
  Rat   631 LEDQDEVL--HCQFSDNSDDEDSEGQ--------EKPRVRSRSHSWVKKPGSVCSLVEMS----- 680

  Fly   618 ASQQPPPPIDPESVVDPLESSSGEGIRQAALAAAAATAPIEQLQ-------KKLRKLVAEIEGKQ 675
                       ::..:...|..|.|           ...:|.||       :|||.....:...:
  Rat   681 -----------DTQAECQRSYLGNG-----------DLKMESLQESQELNLQKLRTSELILNKAK 723

  Fly   676 RQLREIEETIQVKQNIIAELVKNSDTRSHAKQRFHKKRAKLEAECDKAK-------KQLGKALVQ 733
            :::||:...|::|:::|.||:|..|......:::..|..|||.|.::||       |||.:  ::
  Rat   724 QKMRELTINIRMKEDLIKELIKTGDNAKSVSRQYSLKVTKLEHEAEQAKVELTETRKQLQE--LE 786

  Fly   734 GRDQSEIERWTTI--------------IGHLERRLEDLSSMKHIAGESGQKVKKLQQSVGESRKQ 784
            |:|.|::.....:              :..|:::.:|...:..::.::.::..:|:|:|...:.|
  Rat   787 GKDLSDVALKVKLQKEFRKKMDAAKLRVQVLQKKQQDSKKLASLSIQNEKRASELEQNVDHLKYQ 851

  Fly   785 ADDLQKKLRKECKLRCQMEAE-------------------------------------------- 805
            ...||::||:|.:.:.|::||
  Rat   852 KVQLQRRLREESEKKKQLDAEVKRDQQKLKELQLNAGQGEGLHPKAEDTDAFNLNRRKGPFRSVD 916

  Fly   806 -LAKLRESRETGKELVKAQGSPEQ-----------------------------QGRQLKA----- 835
             |.||.|.|:...|.|:...|..|                             :.::|::
  Rat   917 QLQKLDEQRKWLDEEVEKVLSQRQELEMLEEELKKREAIVSKKEALLQEKSHLENKKLRSSQALS 981

  Fly   836 -----VQARITHLNHILREKSDNLEEQPGPEQQETLRHEIRNLRGTRDLLLEERCHLDRKLKRDK 895
                 :.||:..|:..|.|||..||..| .|::..:..:::.|:..|:.|..:|..:|.||:..:
  Rat   982 TDSLKISARLNLLDQELSEKSLLLENSP-TEEKVKISEQVQALQREREQLQRQRNSVDEKLRHGR 1045

  Fly   896 VLTQKEERKLLECDEAIEAIDAAIEFKNEMITGHRSIDTSDRIQREKGEQMLMARLNRLSTEEMR 960
            ||:.|||..|.:.:|.|||::||||||||.|...:|...|......:.|..::.:|..|:..|:|
  Rat  1046 VLSPKEEHLLFQLEEGIEALEAAIEFKNESIQNRQSSLKSSFQNLSQSESNVLEKLVCLNIAEIR 1110

  Fly   961 TLLYKYFTKVIDLRDSSRKLELQ-----LVQLERERDAWEWKERVLSNAVRQARLEGERNAVLLQ 1020
            .:|:|||.|||:||::.||.:||     :..|||:....|     |.:|:...||:.:|...|.|
  Rat  1111 AILFKYFNKVINLREAERKQQLQNKEMKMKVLERDNMVHE-----LESALEYLRLQCDRRLTLQQ 1170

  Fly  1021 RQHEMKLTLMLRHMAEETSASSASYGERALAPACVAPPVQASSDFDYDHFYKGGGNPSKALIKAP 1085
            ::||.|:.|:|.|..::.       ||..:
  Rat  1171 KEHEQKMQLLLHHFKDQD-------GEGII----------------------------------- 1193

  Fly  1086 KPMPTGSALDKYKDKEQRSGRNIFAKFH-----------------------VLTRYASAAAAGSS 1127
                  ..|:||:||.|:..::::  |:                       .||.:..   ||..
  Rat  1194 ------ETLNKYEDKIQQLEKDLY--FYKKTSRDLKKRLKDPVQGAVQWQRTLTEHHD---AGDG 1247

  Fly  1128 GSTAEESTALIESTTTATAT 1147
            ....||:..|.|....|:.|
  Rat  1248 VLNPEEAAVLSEELKWASRT 1267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	90/292 (31%)
cos	NP_001260765.1	SPEC	657..856	CDD:295325	60/310 (19%)
Kif27	NP_932167.1	KISc_KIF4	4..342	CDD:276823	90/295 (31%)
		KISc	5..348	CDD:214526	92/301 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	551..583		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..664		7/29 (24%)
		SbcC	<702..1222	CDD:223496	133/577 (23%)
		DUF4200	789..>884	CDD:290574	16/94 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1267..1340		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1375..1394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000