DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cos and osm-3

DIOPT Version :9

Sequence 1:	NP_001260765.1	Gene:	cos / 35653	FlyBaseID:	FBgn0000352	Length:	1201	Species:	Drosophila melanogaster
Sequence 2:	NP_001367796.1	Gene:	osm-3 / 177141	WormBaseID:	WBGene00003884	Length:	699	Species:	Caenorhabditis elegans

Alignment Length:	752	Identity:	163/752 - (21%)
Similarity:	289/752 - (38%)	Gaps:	204/752 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 SSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLTDSTEGVVQLCVRDIF 210
            |:.||:|:..||||:...:||::.:|..|||.|.||::::.|....|    :..||:......||
Worm    58 STGEQIYNDIVFPLVENVIEGYNGTVFAYGQTGSGKTFSMQGIETIP----AQRGVIPRAFDHIF 118

  Fly   211 SHISLHPERTYAINVGFVEICGGDVCDLLGMGN--------------------IH-CTNVDAV-- 252
            :..:......:.::..::||...:|.||||..|                    :| |.:|.|.
Worm   119 TATATTENVKFLVHCSYLEIYNEEVRDLLGADNKQKLEIKEQPDRGVYVAGLSMHVCHDVPACKE 183

  Fly   253 -----FHWLQVG--LSARQSLPAHTLFTLTLEQQWVSKEGLLQHRLSTASFSDLCGTER------ 304
                 |:...||  |..:.|..:|::||:.:|  .:::.|.:  |:...:..||.|:||
Worm   184 LMTRGFNNRHVGATLMNKDSSRSHSIFTVYVE--GMTETGSI--RMGKLNLVDLAGSERQSKTGA 244

  Fly   305 CGDQ-PPGRPLDAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTTLTTLLKDSFGGRAQTLVILCV 368
            .||: .....::..|..|..|||.|.|     |.:.:|||..:.||.||:||.||..:|::|.||
Worm   245 TGDRLKEATKINLSLSALGNVISALVD-----GKSKHIPYRDSKLTRLLQDSLGGNTKTIMIACV 304

  Fly   369 SPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTMIVQPAEPVPESNSSAGPLSQAGPGDNF 433
            ||..::..|||..|::|.:.:.::|...:|....| .::.:..|.:....|...|
Worm   305 SPSSDNYDETLSTLRYANRAKNIKNKPTINEDPKD-ALLREYQEEIARLKSMVQP---------- 358

  Fly   434 GLQFAASQWSKLVTNAEGLFSKLIDSKLITEVEKEQIEEWLFLKQECEECLSSTEAMRQQKQLVP 498
                          .|.|:.:...|:..|.|..|:       |::|.||.::......:::|
Worm   359 --------------GAVGVGAPAQDAFSIEEERKK-------LREEFEEAMNDLRGEYEREQ--- 399

  Fly   499 ILEAEEPEDVNSEAANSESPNSDNENDTDNESHRPDLDDKIESLMEEFRDKTDALILEKHAEYLS 563
            ..:||..:|:.|..|:.|..|::.:|....|:
Worm   400 TSKAELQKDLESLRADYERANANLDNLNPEEA--------------------------------- 431

  Fly   564 KHPKAVMQSQDREIEAQPPEENGDDRKVSIGSRRRSVQPGASLSTAELAMLNRVASQQPPPPIDP 628
              .|.:.|.||:.|..   ||.|:   ..:..:|......|...|.:||....|...
Worm   432 --AKKIQQLQDQFIGG---EEAGN---TQLKQKRMKQLKEAETKTQKLAAALNVHKD-------- 480

  Fly   629 ESVVDPLESSSGEGIRQAALAAAAATAPIEQLQKKLRKLVAEIEGKQRQLREIEETIQVKQNIIA 693
                |||       ::..:.......|...||:|:::|    .:|.:|::.::....::.:....
Worm   481 ----DPL-------LQVYSTTQEKLDAVTSQLEKEVKK----SKGYEREIEDLHGEFELDRLDYL 530

  Fly   694 ELVKNSDTRSHAKQRFHKKRAKL------EAECDKAKKQLGKALVQGRDQSEIERWTTIIGHLER 752
            :.::..|.:.....:...|...:      .:..|:.||:    .|...|:|   ||.
Worm   531 DTIRKQDQQLKLLMQIMDKIQPIIKKDTNYSNVDRIKKE----AVWNEDES---RWI-------- 580

  Fly   753 RLEDLSSMKHI--AGESGQKVKKLQQSVGESRKQADDLQKKLRKECKLRCQMEAELAKLRESRET 815
             |.::|..:.|  ...:|...:..:|.....|...||   |||:               |.::..
Worm   581 -LPEMSMSRTILPLANNGYMQEPARQENTLLRSNFDD---KLRE---------------RLAKSD 626

  Fly   816 GKELVKAQGSPEQQGRQLKAVQARITHLNHILREKSD 852
            .:.|..:...|.:|             :|.|.:.|||
Worm   627 SENLANSYFKPVKQ-------------INVINKYKSD 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	83/279 (30%)
cos	NP_001260765.1	SPEC	657..856	CDD:295325	36/204 (18%)
osm-3	NP_001367796.1	Motor_domain	3..327	CDD:419868	83/281 (30%)
osm-3	NP_001367796.1	SMC_prok_B	<342..559	CDD:274008	49/314 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100