DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cos and Kif7

DIOPT Version :9

Sequence 1:	NP_001260765.1	Gene:	cos / 35653	FlyBaseID:	FBgn0000352	Length:	1201	Species:	Drosophila melanogaster
Sequence 2:	NP_001278151.1	Gene:	Kif7 / 16576	MGIID:	1098239	Length:	1348	Species:	Mus musculus

Alignment Length:	1204	Identity:	300/1204 - (24%)
Similarity:	479/1204 - (39%)	Gaps:	352/1204 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 GPHTVPVTHALPSSSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLTD 196
            |.|.|     |...:.||.||...|.||:..|.|||:|:|..|||.|.||:||: |.....:|.:
Mouse    56 GFHVV-----LGEDTGQEAVYQACVQPLLEAFFEGFNATVFAYGQTGSGKTYTM-GEASVASLHE 114

  Fly   197 STEGVVQLCVRDIFSHISLHPERTYAINVGFVEICGGDVCDLL---------------------- 239
            ..:|::...:.:.|..|..:......::|.::|:...:..|||
Mouse   115 DEQGIIPRAMAEAFKLIDENDLLDCLVHVSYLELYKEEFRDLLEVGTASRDIQLREDDRGNVVLC 179

  Fly   240 GMGNIHCTNVDAVFHWLQVGLSARQ---------SLPAHTLFTLTLEQQWVSKEGLLQ----HRL 291
            |:..:....:|.|...|::|.:||.         |..:||:||:||||:..:...|.:    |.|
Mouse   180 GVKEVDVEGLDEVLSLLEMGNAARHTGATHFNRLSSRSHTVFTVTLEQRGRTPSRLPRPAAGHLL 244

  Fly   292 -STASFSDLCGTER------CGDQ-PPGRPLDAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTTL 348
             |...|.||.|:||      .|:: .....:::.|..|..|||.|.||...   ..:|||..:.:
Mouse   245 VSKFHFVDLAGSERVLKTGSTGERLKESIQINSTLLALGNVISALGDPQRR---GSHIPYRDSKI 306

  Fly   349 TTLLKDSFGGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTMIVQPAEP 413
            |.:||||.||.|:|::|.||||......|||..|.:|.:.|.:||...:|...:        ||.
Mouse   307 TRILKDSLGGNAKTVMIACVSPSSSDFDETLNTLNYASRAQNIRNRATVNWRPE--------AER 363

  Fly   414 VPESNSSA--GP--------------------LSQAGPGDNFGLQFAASQWSKLVTNAEGLFSKL 456
            |||..::.  ||                    :..|......|.:.|..:     ......:|
Mouse   364 VPEEQAAGARGPPRHRSETRIIHRGRRVPCPAVGSAAVAAGLGAECARCR-----ARTSAAYS-- 421

  Fly   457 IDSKLITEVEKE---------QIEEWLFLKQECEECLSSTEAMRQQKQLVPILEAEEPEDVNSEA 512
                |:.|::.|         ::.:||...:.....|||.......      :|:...||   :|
Mouse   422 ----LLRELQAEPGLPGAAARKVRDWLCAVEGERSTLSSASGPDSG------IESAPAED---QA 473

  Fly   513 ANSESPNSDNENDTD-----------NESHRPDLDDKIESLMEEFRDKTDAL------------- 553
            |...|....:|....           .|.:| |....:|..||:::.::|.|
Mouse   474 AQGTSGRKGDEGTQQLLTLQSQVARLEEENR-DFLAALEDAMEQYKLQSDRLREQQEEMVELRLR 537

  Fly   554 ------------ILE------------------KHAEYLSKHPKAVMQSQD----------REIE 578
                        :|:                  .|...|...|...:..::          :|::
Mouse   538 LELAQPGWGAPGLLQGLPPGSFVPRPHTAPLGGAHTHMLGMMPSTCLPGEEVSSEQQVVSGKEVK 602

  Fly   579 AQ--------------PPEENGDDRK--------------------VSIGSRRRSVQPGASLSTA 609
            |:              ..||.|::.:                    :|..|:|..:.||:
Mouse   603 AEVLAQADKLRSASSTTSEEEGEEEEEEEEEEEEPPRRTLYLRRNGISNWSQRAGLSPGS----- 662

  Fly   610 ELAMLNRVASQQPP----PPIDPE--SVVDPLESSSGEG-----IRQAALAAAAATAPIEQLQKK 663
                        ||    |.:.||  :...|...:.|.|     .|||. ||.|:...:.|.|:|
Mouse   663 ------------PPDRKGPEVCPEEPAAAIPAPQAVGSGKVPVQTRQAP-AAMASEWRLAQAQQK 714

  Fly   664 LRKLVAEIEGKQ---------------------RQLREIEETIQVKQNIIAELV----------- 696
            :|:|...|..|:                     :::||:|   |..:.:.|||.
Mouse   715 IRELAINIRMKEELIGELVRTGKAAQALNRQHSQRIRELE---QEAERVRAELCEGQRQLRELEG 776

  Fly   697 ---KNSDTRSHAKQRFHKKRAKLEAECD--KAKKQLGKALVQGRDQS-----EIERWTTII---- 747
               :::..||.. |.|.|:.|..:::..  |.|||..:.||....||     |:||...::
Mouse   777 REPQDASERSRL-QEFRKRVAAAQSQVQVLKEKKQATERLVSLSAQSETRLQELERNVQLMRRQQ 840

  Fly   748 GHLERRLEDLSSMK-----------------HIAGESGQKVKKL--QQSVGESRKQAD------- 786
            |.|:|||.:.:..|                 .:..|..||:.|:  ::.....||:..
Mouse   841 GQLQRRLREETEQKRRLETEMNKRQHRVKELELKHEQQQKILKIKTEEIAAFQRKRRSGSNGSVV 905

  Fly   787 --DLQKKLRKECK-LRCQMEAELAKLRESRETGKELVK-----------AQGSPEQQGRQLKAVQ 837
              :.|:|:.::.| |..:||..|.:.|...|.|:||.|           .|.....:.::|::.|
Mouse   906 SLEQQQKIEEQKKWLDQEMEKVLQQRRALEELGEELRKREVILAKKEALMQEKTGLESKRLRSSQ 970

  Fly   838 A----------RITHLNHILREKSDNLEEQPGPEQQETLRHEIRNLRGTRDLLLEERCHLDRKLK 892
            |          |:.||...|.|||..| .|...:.|:.:|.||..||..:|.||::|..:|.||:
Mouse   971 ALNEDIVRVSSRLEHLEKELSEKSGQL-RQGSAQNQQQIRGEIDTLRQEKDSLLKQRLEIDSKLR 1034

  Fly   893 RDKVLTQKEERKLLECDEAIEAIDAAIEFKNEMITGHRSIDTSDRIQREKGEQMLMARLNRLSTE 957
            :..:|:.:|||.|.:.||||||:|||||:|||.||..:.:..:......:.|..|||:|:.||:.
Mouse  1035 QGSLLSPEEERTLFQLDEAIEALDAAIEYKNEAITCRQRVLRASASLLSQCEMNLMAKLSYLSSS 1099

  Fly   958 EMRTLLYKYFTKVIDLRDSSRKLELQL----VQLERERDAWEWKERVLSNAVRQARLEGERNAVL 1018
            |.|.||.|||.||:.||:...:.::..    :|||.::....|    |..|:.:.|||.:|...|
Mouse  1100 ETRALLCKYFDKVVTLREEQHQQQIAFSELEMQLEEQQRLVYW----LEVALERQRLEMDRQLTL 1160

  Fly  1019 LQRQHEMKLTLMLR----HMAEETSASSASYGER 1048
            .|::||..:.|:|:    |:.|..:.|...|..|
Mouse  1161 QQKEHEQNVQLLLQQGRDHLGEGLADSKRQYEAR 1194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	92/299 (31%)
cos	NP_001260765.1	SPEC	657..856	CDD:295325	68/294 (23%)
Kif7	NP_001278151.1	KISc_KIF4	15..350	CDD:276823	93/302 (31%)
		Interaction with SMO. /evidence=ECO:0000269\|PubMed:25644602	358..1211		204/893 (23%)
		Interaction with DLG5. /evidence=ECO:0000269\|PubMed:25644602	358..479		24/148 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..486		10/43 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..674		11/83 (13%)
		Smc	<734..1063	CDD:224117	90/333 (27%)
		PRK11281	949..>1202	CDD:236892	86/251 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1288..1314
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1328..1348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7925
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.860