DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and KIRREL3

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	XP_011541328.1	Gene:	KIRREL3 / 84623	HGNCID:	23204	Length:	809	Species:	Homo sapiens

Alignment Length:	717	Identity:	159/717 - (22%)
Similarity:	254/717 - (35%)	Gaps:	167/717 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   440 QEETMEPGPSVFLKCVAGGNPTPE----ISWELDGKKI-ANNDRYQVGQYVTVNGDVVS---YLN 496
            |::.:..|..|.|.|.     .||    :.|..||..: ...|.....||:.| |:.:|   :|.
Human    61 QDQVVVSGQPVTLLCA-----IPEYDGFVLWIKDGLALGVGRDLSSYPQYLVV-GNHLSGEHHLK 119

  Fly   497 ITSVHANDGGLYKCIAKSKVGVAEHSAKLNV---------YGLPYIRQMEKKAIVAGETLIVTCP 552
            |......|..:|:|.| .:..:....|:|.|         .|.|.|      ::.||:.|.:||.
Human   120 ILRAELQDDAVYECQA-IQAAIRSRPARLTVLVPPDDPVILGGPVI------SLRAGDPLNLTCH 177

  Fly   553 V-AGYPIDSIVWERDNRA----------LPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQE 606
            . ...|..||:|.|....          |...:::.:.  .||.|...:..:.| :..|.|.|:
Human   178 ADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIV--STLFISPGDVENGQ-SIVCRATNK- 238

  Fly   607 GYSARGSLEVQVMV---LPQIVPFAYEDLINMGDSIDLF-CQIQKGDRPIKVHWS---------- 657
              :..|..|..|.:   .|.:|..:.|....:.|::..| |..:......:..|:
Human   239 --AIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEAS 301

  Fly   658 --FERSAGDYGFDQVQPQMRTNRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNV 720
              ..|:..||.:           .||..|                |..:|..|:|..|..:.|..
Human   302 GEVYRTTVDYTY-----------FSEPVS----------------CEVTNALGSTNLSRTVDVYF 339

  Fly   721 PPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVD 785
            .||...||.......||||...|...|.|...:.|.|            :.|..:...|.||.:.
Human   340 GPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMK------------RGSGVVLSNEKTLTLK 392

  Fly   786 NIQKTNEGYYLCEA-INGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIG 849
            ::::.:.|.|:|.| :..:|:| ...:.::|..|| .....:.|.|..||...::|..:...|..
Human   393 SVRQEDAGKYVCRAVVPRVGAG-EREVTLTVNGPP-IISSTQTQHALHGEKGQIKCFIRSTPPPD 455

  Fly   850 -ILWNMNNMRLDPKNDNRYTIREEILST--GVMSSLSIKRTERSD-SALFTCVATNAFGSDDASI 910
             |.|:.....|:.....|||:  |.:||  ||:|:|:|....|:| ..::.|.|.|:||||...|
Human   456 RIAWSWKENVLESGTSGRYTV--ETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEII 518

  Fly   911 NMIVQ----------EVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEI 965
            .:..|          |...:|.|:.:....|..|..         ..|...|:.|..:|:..|..
Human   519 RLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAF---------LVLMATIVAFCCARSQRSTG 574

  Fly   966 DRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQ 1030
            .|..:.|..||.:.:...|...        |..|...:...:.:....:.|:...:..:...:.|
Human   575 GRSGISGRGTEKKARLRLPRRA--------NLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ 631

  Fly  1031 TTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQ--Y 1093
            ..|.           .||.            ....|.:.:..:.||.|    |.|||:..|.  |
Human   632 LMMD-----------RGEF------------QQDSVLKQLEVLKEEEK----EFQNLKDPTNGYY 669

  Fly  1094 SV 1095
            ||
Human   670 SV 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352	24/94 (26%)
		IGc2	446..517	CDD:197706	21/78 (27%)
		I-set	533..618	CDD:254352	21/95 (22%)
		IGc2	544..607	CDD:197706	17/73 (23%)
		Ig	641..714	CDD:143165	13/85 (15%)
		IGc2	735..804	CDD:197706	17/69 (25%)
		I-set	819..914	CDD:254352	31/98 (32%)
		Ig	833..921	CDD:299845	30/101 (30%)
		FN3	918..1011	CDD:238020	16/92 (17%)
		FN3	1018..1116	CDD:238020	16/80 (20%)
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
KIRREL3	XP_011541328.1	Ig	58..149	CDD:299845	24/94 (26%)
		IG_like	60..149	CDD:214653	24/94 (26%)
		I-set	156..249	CDD:254352	23/104 (22%)
		Ig2_KIRREL3-like	171..252	CDD:143236	19/86 (22%)
		Ig_2	260..337	CDD:290606	16/103 (16%)
		I-set	341..422	CDD:254352	23/93 (25%)
		IGc2	355..406	CDD:197706	16/62 (26%)
		Ig5_KIRREL3	424..521	CDD:143306	32/99 (32%)
		IG_like	432..521	CDD:214653	30/90 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10991
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810