DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and KIRREL2

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_954649.3	Gene:	KIRREL2 / 84063	HGNCID:	18816	Length:	708	Species:	Homo sapiens

Alignment Length:	724	Identity:	154/724 - (21%)
Similarity:	253/724 - (34%)	Gaps:	177/724 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 RAVVSQHYEEDIHKAFVIRGNSAILKCDIPSFVADFVNVISWHSDEKENFYPGTEYD----GKYL 194
            ||..|.|:.:......|:.|..|.|.|.:.:    :..::.|   .|.....|.:.|    .:|.
Human    19 RAGPSPHFLQQPEDLVVLLGEEARLPCALGA----YWGLVQW---TKSGLALGGQRDLPGWSRYW 76

  Fly   195 VLPSG-------ELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPVGSVSPQLSGN 252
            :  ||       :||||.|..|| ..||:|:..     :..|.:...:|.:..|  ..:||:.|.
Human    77 I--SGNAANGQHDLHIRPVELED-EASYECQAT-----QAGLRSRPAQLHVLVP--PEAPQVLGG 131

  Fly   253 GNQEHITLTR-VPKMGSVTLMCPAQAYPVPFFRWYK---FIEGTTRKQAVVLNDRVKQVSGTLII 313
            .:   ::|.. ||  .::|......|.|.|...|::   .::|.|..|.::.......|..||.:
Human   132 PS---VSLVAGVP--ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTL 191

  Fly   314 KDAVVEDSGKYLCVVNNSV--GGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGN-PI 375
            .....:|...::|...:..  .|......|::..|....:.....||..|...:|.||.|.. |:
Human   192 TPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPV 256

  Fly   376 KTVSWMKDGK-AIGHSEPVLRIESVKKEDKGMYQCFVRNDQESAEASAELK-LGGRFDPPVIRQA 438
            ....|.|.|. .:|...|.|.:.:..........|.|.|...||..|..|. |.|    |:::..
Human   257 TGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFG----PILQAK 317

  Fly   439 FQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHAN 503
            .:..:::.|......|...|||.|.::|...|           |..|..:|   :.|.:.||...
Human   318 PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-----------GAQVLGSG---ATLRLPSVGPE 368

  Fly   504 DGGLYKCIAKS-----KVGVAEHSAKLNVYGLPYIRQMEK-KAIVAGETLIVTCPVAGYPI-DSI 561
            |.|.|.|.|::     :.|.||  |:|.|...|.:..:.. .|.:.|...: .|.|...|. |::
Human   369 DAGDYVCRAEAGLSGLRGGAAE--ARLTVNAPPVVTALHSAPAFLRGPARL-QCLVFASPAPDAV 430

  Fly   562 VWERDNRALPINRKQK----VFPN------------GTLIIENVERNSDQATYTCVAKNQEGY-S 609
            ||..|...|....:.:    .||.            ..|.|...:.:....::.|.|:|:.|. .
Human   431 VWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGG 495

  Fly   610 ARGSLEVQVMVLPQI-----VPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERSAGDYGFDQ 669
            |:.||..:.: ||.:     |..|...|:.:...:.|.|            |...:::..:
Human   496 AQASLGRRDL-LPTVRIVAGVAAATTTLLMVITGVALCC------------WRHSKASASF---- 543

  Fly   670 VQPQMRTNRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFA 734
                      ||:.:::.||.:|...:.|.
Human   544 ----------SEQKNLMRIPGSSDGSSSRG----------------------------------- 563

  Fly   735 QGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEA 799
                          |:.:.|..:   :..|.......||.:..|||||...:  .|| |||   .
Human   564 --------------PEEEETGSR---EDRGPIVHTDHSDLVLEEEGTLETKD--PTN-GYY---K 605

  Fly   800 INGIGSGLS 808
            :.|:...||
Human   606 VRGVSVSLS 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653	15/80 (19%)
		Ig	269..340	CDD:143165	14/75 (19%)
		IG_like	353..425	CDD:214653	20/73 (27%)
		IGc2	361..413	CDD:197706	14/53 (26%)
		I-set	433..527	CDD:254352	25/98 (26%)
		IGc2	446..517	CDD:197706	19/75 (25%)
		I-set	533..618	CDD:254352	21/103 (20%)
		IGc2	544..607	CDD:197706	16/79 (20%)
		Ig	641..714	CDD:143165	9/72 (13%)
		IGc2	735..804	CDD:197706	16/68 (24%)
		I-set	819..914	CDD:254352
		Ig	833..921	CDD:299845
		FN3	918..1011	CDD:238020
		FN3	1018..1116	CDD:238020
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
KIRREL2	NP_954649.3	IG_like	30..119	CDD:214653	24/103 (23%)
		IGc2	38..106	CDD:197706	21/77 (27%)
		I-set	126..224	CDD:254352	21/102 (21%)
		Ig2_KIRREL3-like	141..223	CDD:143236	16/83 (19%)
		Cell attachment site. /evidence=ECO:0000255	149..151		0/1 (0%)
		Ig	231..306	CDD:299845	20/74 (27%)
		IG_like	234..308	CDD:214653	21/73 (29%)
		Ig	312..395	CDD:299845	25/98 (26%)
		I-set	317..395	CDD:254352	24/93 (26%)
		Ig	397..501	CDD:299845	21/104 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..601		15/109 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10991
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810