DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and Lifr

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_112310.1	Gene:	Lifr / 81680	RGDID:	621431	Length:	1093	Species:	Rattus norvegicus

Alignment Length:	1246	Identity:	257/1246 - (20%)
Similarity:	420/1246 - (33%)	Gaps:	340/1246 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 GNPTPEISWELDGKKIANNDRYQVGQYVTVNG---DVVSYLNITSVHANDGGLYKCIAKSKVGVA 519
            |..||.:.|.|....:.:       ..:.|||   .|...|..|:   |:..::.|...:.:||:
  Rat    19 GRMTPSLPWLLSALTLLH-------LMMHVNGLKRGVQQDLKCTT---NNMRVWDCSWPAPLGVS 73

  Fly   520 EHSAK-LNVYGLPY------IRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQK 577
            ..:.| :.:...|:      ...::..|:..|:..:......|:.....:.|:|...:|...
  Rat    74 PGTVKDICIKDRPHSCHRLETTNVKIPALSPGDHEVTINYQNGFQSKFTLNEKDVSLVPDTP--- 135

  Fly   578 VFPNGTLIIENVERNSDQATYTCVAK-NQEG----YSARGSLEVQVMVLPQIVPFAYEDLINMGD 637
                     |.:..::|.:|.|...| |.:|    |.:..:.||:|:..|:..|.|...|..:..
  Rat   136 ---------EILSLSADFSTSTLQLKWNDKGSALPYPSNATWEVKVLQNPRTEPVALVSLNTVLS 191

  Fly   638 SIDLFCQIQKGDRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKTSMISIPSASPAHTGRDTCI 702
            ..|      ||.     ||::.        .::..|..|:.:|.:.. |..|..|......:...
  Rat   192 GKD------KGH-----HWNWT--------SELPLQCATHSVSIRWH-IDYPRFSGYKEWSEWSP 236

  Fly   703 ASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYK 767
            ..|.:.|.....::.          |.||....||:..:.|.:        |.|...|.....::
  Rat   237 LKNISWTRNTETNVF----------PQDKVVLAGSNMTICCIS--------TTKVLSGQIGNTFR 283

  Fly   768 DLKKSDNIRVEEGTLHVDNIQ-KTNEGYYLCEAINGIGSGLSAVIMISVQA--PPEFTEKLRNQT 829
            .|   .::..|...:::.||. ..|.|      .|.|.|.:..|....|.|  ||:..:|
  Rat   284 PL---IHLYGETVAINILNIPVSENSG------SNVIFSTVDDVYGTVVFAGYPPDVPQK----- 334

  Fly   830 ARRGEPAVLQCEAKGEKPIGILWNMNNMR--LDPKNDNRYTIREEILSTGVMSS----------- 881
                    |.||....|.|...||...:.  :.|:| ..||:.|.|.....:..
  Rat   335 --------LSCETHDLKEIICSWNPGRITGLVGPRN-TEYTLFESISGKSAVFHRFEELANETYW 390

  Fly   882 LSIKRTERSDSALFTCVATNAFGSDDAS--INMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDG 944
            |::|.....:...||..|.|..|..:::  ||...:....:|.:|||.|.:...|.|||..|  |
  Rat   391 LTLKMAPDQEIHNFTLTARNPLGQTESAIVINATERVALHVPISLKVKDVNSTVVTLSWYLP--G 453

  Fly   945 NSPLDRYIIEFKRSRA-SWSEIDRVIVPG---HTTEAQVQKLSPAT--TYNIRIVAENAIGTSQS 1003
            |......:.:.:..:| |..|:..|.:.|   .|....|.||:|.|  |:.:|..:|.....|:.
  Rat   454 NFTKINLVCQIEICKANSKKEVRNVTMRGAEDSTYHVAVDKLNPYTIYTFRVRCSSETFWKWSKW 518

  Fly  1004 SEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFE 1068
            |.....:|.|..||..|...:....:...:.:.|||.|..|.||:||.|.|     :.:||...:
  Rat   519 SNEKRYLTTEATPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNV-----SCSSSEETQ 578

  Fly  1069 TINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSE------EEKQFTAEGTP------ 1121
            :::.|.:  .:|..|::..:  ..|.:.:.|.|..|:.|.|:      .....|.|...
  Rat   579 SLSEILD--PQHKAEIKVNK--NDYIISVVARNSAGSSPPSKIASMEIPNDDITVEQAVGIGNRI 639

  Fly  1122 ----SQPPSDTA------CTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYK 1176
                ...|:.|.      |.:..|:...:.|:..|..|...||:        ||::....:.::
  Rat   640 FLSWQHNPNMTCDYVIKWCNSSWSEPCLLDWIKVPSNSTGTVIE--------SDQFQPGVRYNF- 695

  Fly  1177 KTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVP-EAPT----DVKALVMGNA 1236
                   .|:|.   ||...|:|.:|.|           ..|...| .||.    |..|     .
  Rat   696 -------YLYGC---TNQGYQLLRSTIG-----------YIEELAPIVAPNFTVEDTSA-----D 734

  Fly  1237 AILVSWR--PPAQPNGIITQYTVY-SKAEGAETETKTQKVPH-----------YQMSFEATELEK 1287
            :|||.|.  |..:..|.:..|..| .|.|....:|::.:..|           .|.:....:|:.
  Rat   735 SILVKWDDIPVEELRGFLRGYLFYFQKGERDTPKTRSLETSHSDIKLKNITDISQKTLRIADLQG 799

  Fly  1288 NKPYEFWVTASTTIGEGQQSKSIVAMPSDQV--------PAKIASFDDTFTA------------T 1332
            ...|...:.|.|..|.|.:....|....:.|        |..:|......|:            |
  Rat   800 KTSYHLVLRAYTHGGLGPEKSMFVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKET 864

  Fly  1333 FKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAK 1397
            |..|         .|.||   ..|.::|.               |||         |...|::
  Rat   865 FYPD---------IPNPE---NCKALQFQ---------------KSV---------CEGSNAL-- 891

  Fly  1398 DSITHKLIVLAPPQSPHVTLSAT---------TTDALTVKLKPHE-GDTAPLHGYTLHYKPEFGE 1452
                 |.:.:.|....||.:..:         |.....|..:|.| .:|.|.:...:.|.|...|
  Rat   892 -----KTLEMNPCTPNHVEVLESRSIPPKIEDTEITSPVSERPGESSETDPENQAAVSYCPPIIE 951

  Fly  1453 WETSEVSVD-----SQKHNIEGLLCGSRYQ-------------VYATGF------------NNIG 1487
            .|.:..:.|     ||...|:   ..|.||             |...|:            .:..
  Rat   952 EEITNPAADEAGGASQVVYID---VQSMYQPQAKAEDEQDTDPVMVAGYKPQMRLPINPTAEDTT 1013

  Fly  1488 AGEASDILNTRTKGQKPKL---------PEKPRFIEVSSNSVSLHFKAWKDGGCPMS----HFVV 1539
            |.:.:|    :|.|.:|:.         |:.||..:.:|..||.        |.|.|    .|::
  Rat  1014 AEDEAD----KTAGYRPQANVNTWNLVSPDSPRSTDSNSEVVSF--------GSPCSINSRQFLI 1066

  Fly  1540 ESKKRDQIEWN 1550
            ..|..|..:.|
  Rat  1067 PPKDEDSPKSN 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352	16/72 (22%)
		IGc2	446..517	CDD:197706	13/61 (21%)
		I-set	533..618	CDD:254352	16/89 (18%)
		IGc2	544..607	CDD:197706	11/63 (17%)
		Ig	641..714	CDD:143165	12/72 (17%)
		IGc2	735..804	CDD:197706	13/69 (19%)
		I-set	819..914	CDD:254352	24/109 (22%)
		Ig	833..921	CDD:299845	22/102 (22%)
		FN3	918..1011	CDD:238020	28/98 (29%)
		FN3	1018..1116	CDD:238020	23/103 (22%)
		FN3	1124..1217	CDD:238020	19/98 (19%)
		FN3	1222..1312	CDD:238020	24/108 (22%)
		Ig	1339..1406	CDD:299845	11/66 (17%)
		FN3	1409..1499	CDD:238020	24/129 (19%)
		FN3	1504..1584	CDD:238020	14/60 (23%)
		Dscam_C	1890..2008	CDD:289151
Lifr	NP_112310.1	FN3	332..>368	CDD:304408	12/49 (24%)
		FN3	432..526	CDD:238020	28/95 (29%)
		WSXWS motif	515..519		1/3 (33%)
		fn3	<552..615	CDD:278470	21/71 (30%)
		FN3	725..817	CDD:238020	20/96 (21%)
		Box 1 motif	865..873		3/16 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	908..941		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1003..1093		18/87 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910