DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam1 and USH2A

DIOPT Version :9

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:NP_996816.3 Gene:USH2A / 7399 HGNCID:12601 Length:5202 Species:Homo sapiens


Alignment Length:2363 Identity:455/2363 - (19%)
Similarity:742/2363 - (31%) Gaps:865/2363 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PNERLKWLMLFAAVALIACGSQTLAANPPDADQKGPVFLKEPTNRIDFSNSTGAEIECKASGNPM 68
            ||... |:.:.....:.:..|..|.|...|.:.:|   :..|  .:...|||...:...:..||.
Human  2989 PNTEY-WIFISVFNGVHSINSAGLHATTCDGEPQG---MLPP--EVVIINSTAVRVIWTSPSNPN 3047

  Fly    69 PEI----IWIRSDGTAVG-DVPG---LRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARN---- 121
            ..:    |::.:.....| :|||   ||.:|        ||...|.:.|| ..:|||:..|    
Human  3048 GVVTEYSIYVNNKLYKTGMNVPGSFILRDLS--------PFTIYDIQVEV-CTIYACVKSNGTQI 3103

  Fly   122 -------------QFGSIISRDVHVRAV---------------------------VSQHYEEDIH 146
                         ....|.||.:.:..|                           :.|...:::.
Human  3104 TTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDLLWKTWYPCAKTQKLVQDQSDELC 3168

  Fly   147 KAFVIRGNSAILKCDIPSFVADFVNVISWHSDEKENFYPGTEY---------DGKYL--VLPSGE 200
            ||         ::|..|..:...:    .:|.|.:....|..|         :.||:  ||.|..
Human  3169 KA---------VRCQKPESICGHI----CYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTG 3220

  Fly   201 L----HIREVGPEDGYKSYQCRTKHR---LTGE--------TRLS-------------ATKGRLV 237
            :    .|:|..|     ::||.:.:.   |.||        .|:|             :|.|..:
Human  3221 VCCGGRIQEAQP-----NHQCCSGYYARILPGEVCCPDEQHNRVSVGIGDSCCGRMPYSTSGNQI 3280

  Fly   238 -----ITEPVGS-------VSPQLSGNGNQEHITLTRVPKM---------GSVTLMCPAQA---- 277
                 :.:..|.       ||..|...|.:|.:...|:|.|         .|.|:.|.|.:    
Human  3281 CCAGRLHDGHGQKCCGRQIVSNDLECCGGEEGVVYNRLPGMFCCGQDYVNMSDTICCSASSGESK 3345

  Fly   278 ------YPVP--------FFRWYKFIEGT-TRKQAVVLNDRV------KQVSGTLIIKDA---VV 318
                  .|||        ..:..|...|. ......|.:|::      |:.....|:..|   ..
Human  3346 AHIKKNDPVPVKCCETELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASMEAT 3410

  Fly   319 EDSGK-------YLCVV----NNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTG 372
            |..|:       ::|.|    :||.|..|:|.:.:     ||:     :|:..|  :|.|..||.
Human  3411 EHCGRCDFNFTSHICTVIRGSHNSTGKASIEEMCS-----SAE-----ETIHTG--SVNTYSYTD 3463

  Fly   373 NPIKTV--------SWMKDGKAI--------------GHSEPV-LRIESVKK----------EDK 404
            ..:|..        :|...|:.:              |.|.|. .:|::::.          :..
Human  3464 VNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRKPIQSN 3528

  Fly   405 G--MYQCFVRN-------------DQES----AEASAELK----LGGRFDPPVIRQAFQ--EETM 444
            |  :|...:||             |:|.    .|.|.:||    .|......|:....|  .|::
Human  3529 GPIIYYILLRNGIERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESI 3593

  Fly   445 EPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQ--------------YVTVNGDVVSYL 495
            .|.....|..||     ..:||.:..|.......||:.|              ..||.| :..|.
Human  3594 LPPSITALSAVA-----LHLSWSVPEKSNGVIKEYQIRQVGKGLIHTDTTDRRQHTVTG-LQPYT 3652

  Fly   496 N--ITSVHANDGGLYKCIAKSK-VGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYP 557
            |  .|.......|   |.:... :|....:|...|:..|       :.|:...|.:         
Human  3653 NYSFTLTACTSAG---CTSSEPFLGQTLQAAPEGVWVTP-------RHIIINSTTV--------- 3698

  Fly   558 IDSIVWERDNRALPINRKQKVFPNGTLII-----------ENVERNSDQATYTCVAKNQEGYSAR 611
              .:.|....:...:..:.::..||.|:.           :|:|.|| :.||....|...|.||.
Human  3699 --ELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNS-RYTYKLEVKTGGGSSAS 3760

  Fly   612 GSLEVQV------------------------------MVLPQIVPFAYEDLINMGD--------- 637
            ....||.                              :::|:| |..|..|:|.|.         
Human  3761 DDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPGILIPEI-PVEYNVLLNDGSVTPLAFSVG 3824

  Fly   638 ------------------------------------------SIDLFCQIQK--GDRPIKVHWS- 657
                                                      .:||...:.|  |...|::.|. 
Human  3825 HHQSTLLENLTPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPMDLNSPVLKALGSACIEIKWMP 3889

  Fly   658 -------------FERSAG------------------DYGFDQVQP----QMRTNRISEKTSMIS 687
                         :.|.||                  |.| |.::|    :.|....:.|.|:.|
Human  3890 PEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEG-DTLRPFTLYEYRVRACNSKGSVES 3953

  Fly   688 IPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQ 752
            :                       :|:..|:..||:....|    :||.:.|.         ...
Human  3954 L-----------------------WSLTQTLEAPPQDFPAP----WAQATSAH---------SVL 3982

  Fly   753 VTWKKAVGDTP----GEYKDL--KKSDNIRVEEGTLHVDNIQKTNEGYYL------------CEA 799
            :.|.|.  ::|    ..|:.:  ::.|:......|:|...::.|:...:|            ..|
Human  3983 LNWTKP--ESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVA 4045

  Fly   800 INGIGSGLSAVIMI-SVQAPP-------------------EFTEKLRNQTA-------------- 830
            .|..|..||...:| ::::.|                   :::|.:|....              
Human  4046 ANHAGEILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSDGFLEY 4110

  Fly   831 ---------RRGEPAVL------QCEAKG------------EKP----------------IGILW 852
                     ||.:|..|      .|...|            |.|                :.:.|
Human  4111 SGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSW 4175

  Fly   853 NMNNMRLDPKNDNRYTIREEIL----------STGVMSSLSI----KRTER-----SDSAL---- 894
            :      :|.|.|...||.|::          :..:.:...|    ..|||     :|:.|    
Human  4176 S------EPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWT 4234

  Fly   895 ---FTCVATNAFGSDDASINMI--VQEVPE--MPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYI 952
               :.....|:.|...:|.|::  :|..||  .|..:..:..:.:.:.:||..|...|..:..|.
Human  4235 QCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYR 4299

  Fly   953 IEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPS 1017
            ::.......:| .|.|.. .:|.|    :|.|.:||:..:.|..:.|.| :|:..:|.|.|.|||
Human  4300 LQRNEMLYPFS-FDPVTF-NYTDE----ELLPFSTYSYALQACTSGGCS-TSKPTSITTLEAAPS 4357

  Fly  1018 GKPQNIKVEP-----VNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEG 1077
                  :|.|     |:.|.|.|.|.||  |..||:|..|.|.|  .|..|.           .|
Human  4358 ------EVSPPDLWAVSATQMNVCWSPP--TVQNGKITKYLVRY--DNKESL-----------AG 4401

  Fly  1078 KEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGW 1142
            :...|.:.:|:.|:||:..:.|... |....|..:..:|.|..|....|.|...| .|::|.:.|
Human  4402 QGLCLLVSHLQPYSQYNFSLVACTN-GGCTASVSKSAWTMEALPENMDSPTLQVT-GSESIEITW 4464

  Fly  1143 VSPPLESANGVIKTYK------VVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLAT 1201
             .|| .:.||.|::|:      :||...:..|.:.           |:..|::    |:..|.|:
Human  4465 -KPP-RNPNGQIRSYELRRDGTIVYTGLETRYRDF-----------TLTPGVE----YSYTVTAS 4512

  Fly  1202 TAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAET 1266
            .:.| |:.|..:..:|.|..|......|....|...|||:|.||.:.||.|..||::.: |..|.
Human  4513 NSQG-GILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIR-ELFER 4575

  Fly  1267 ETKTQKV--PHYQMSFEATELEKNKP---YEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFD 1326
            |||...:  .|.....::..:.:.||   ||..:.|.||:|                   .||.|
Human  4576 ETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLG-------------------CASSD 4621

  Fly  1327 DTFTATFKEDAKM----PCLAV----GAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQD 1383
            .||..| .|.|.:    |.|.|    |..||.::....|         .:.|:|.:|...:.|:.
Human  4622 WTFIQT-PEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTG---------PLQPNGKVLYYELYRRQ 4676

  Fly  1384 AG------------------------------DYSCHAENSIAK--DSITHKLIVLAPPQ---SP 1413
            ..                              :|...|.||..|  .|.|......|||:   :|
Human  4677 IATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRAP 4741

  Fly  1414 --HVTLSATTTDALTVKLKP------HEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGL 1470
              ||..|......::...||      :...::..||         .|...||.....|  .:.||
Human  4742 TFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHG---------AETVLSEGMATQQ--TLHGL 4795

  Fly  1471 LCGSRYQV---YATGFNNIGAGEASDI-----------------LNTRTKGQKPKLPEKPRFIEV 1515
            ...:.|.:   ..|.||....|..:::                 |.:||...:...|..|..: :
Human  4796 QAFTNYSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGV-I 4859

  Fly  1516 SSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVL-------DLEPATWY 1573
            .|..:..|.....|...|.:...:|:|                   |..|       .|:|.|.|
Human  4860 HSYELQFHVACPPDSALPCTPSQIETK-------------------YTGLGQKASLGGLQPYTTY 4905

  Fly  1574 NLRITAHNSAGFTVAEY-DFATLTVTGGTIAPLDDGS--------------------------GH 1611
            .||:.|||..|.|.:|: .|.|........||....|                          |.
Human  4906 KLRVVAHNEVGSTASEWISFTTQKELPQYRAPFSVDSNLSVVCVNWSDTFLLNGQLKEYVLTDGG 4970

  Fly  1612 GNVHTRIRLPAWMPEWLDLNFMVPLIATV-----------VVVAVGICVVCVALSRRRADDMRGG 1665
            ..|::.:....::|...|..|...:|.|.           ...:.|:.:|.....:::..  |..
Human  4971 RRVYSGLDTTLYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGS--RSK 5033

  Fly  1666 QKDVYYDVVYNQTMGP-GATL------------DKRRPDLRDELGYIAPPNRKLPPV----PGSN 1713
            ..:.|.::.:...|.. |..|            ..:.|.:| |...:.|..:::.|:    ||.|
Human  5034 STEFYSELWFIVLMAMLGLILLAIFLSLILQRKIHKEPYIR-ERPPLVPLQKRMSPLNVYPPGEN 5097

  Fly  1714 YNTCDRIKRGRGG----LRSNHS 1732
            :......|..|.|    :|||.|
Human  5098 HMGLADTKIPRSGTPVSIRSNRS 5120

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 Ig 38..130 CDD:299845 26/116 (22%)
IG 57..133 CDD:214652 22/100 (22%)
IG_like 267..343 CDD:214653 23/114 (20%)
Ig 269..340 CDD:143165 22/109 (20%)
IG_like 353..425 CDD:214653 21/123 (17%)
IGc2 361..413 CDD:197706 14/86 (16%)
I-set 433..527 CDD:254352 23/112 (21%)
IGc2 446..517 CDD:197706 18/87 (21%)
I-set 533..618 CDD:254352 17/95 (18%)
IGc2 544..607 CDD:197706 12/73 (16%)
Ig 641..714 CDD:143165 16/110 (15%)
IGc2 735..804 CDD:197706 13/86 (15%)
I-set 819..914 CDD:254352 28/198 (14%)
Ig 833..921 CDD:299845 26/151 (17%)
FN3 918..1011 CDD:238020 22/94 (23%)
FN3 1018..1116 CDD:238020 27/102 (26%)
FN3 1124..1217 CDD:238020 23/98 (23%)
FN3 1222..1312 CDD:238020 28/94 (30%)
Ig 1339..1406 CDD:299845 18/106 (17%)
FN3 1409..1499 CDD:238020 22/120 (18%)
FN3 1504..1584 CDD:238020 19/86 (22%)
Dscam_C 1890..2008 CDD:289151
USH2ANP_996816.3 LamGL 146..283 CDD:214722
Laminin_N 291..516 CDD:413488
EGF_Lam 517..565 CDD:238012
EGF_Lam 574..639 CDD:238012
Laminin_EGF 641..691 CDD:395007
EGF_Lam 694..733 CDD:214543
Laminin_EGF 747..795 CDD:395007
EGF_Lam 794..844 CDD:238012
EGF_Lam 847..897 CDD:214543
EGF_Lam 900..948 CDD:238012
EGF_Lam 950..1000 CDD:238012
EGF_Lam 1001..>1037 CDD:238012
fn3 1058..1132 CDD:394996
fn3 1150..1227 CDD:394996
FN3 1242..1357 CDD:238020
FN3 1368..1451 CDD:214495
LamG 1519..1678 CDD:238058
LamG 1716..1868 CDD:238058
FN3 1956..2051 CDD:238020
FN3 2241..2313 CDD:238020
FN3 2329..2428 CDD:238020
FN3 2432..2528 CDD:238020
FN3 2533..2619 CDD:238020
FN3 2621..2719 CDD:238020
FN3 2724..2799 CDD:238020
FN3 2818..2920 CDD:238020
FN3 2925..3015 CDD:238020 6/26 (23%)
FN3 3026..>3087 CDD:238020 17/70 (24%)
FN3 <3449..3494 CDD:238020 9/46 (20%)
FN3 3503..3586 CDD:238020 15/82 (18%)
FN3 3590..3676 CDD:238020 20/94 (21%)
FN3 3680..3767 CDD:238020 20/105 (19%)
fn3 3777..3856 CDD:394996 7/79 (9%)
FN3 3866..3960 CDD:238020 18/117 (15%)
FN3 3964..4057 CDD:238020 20/107 (19%)
fn3 4161..4247 CDD:394996 14/91 (15%)
FN3 4268..4351 CDD:238020 20/89 (22%)
fn3 4357..4428 CDD:394996 26/92 (28%)
FN3 4444..4516 CDD:238020 21/89 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4518..4541 5/22 (23%)
FN3 4529..4627 CDD:238020 34/117 (29%)
FN3 4636..4730 CDD:238020 18/102 (18%)
FN3 4826..4927 CDD:238020 26/120 (22%)
PDZ-binding 5200..5202
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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