DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and Il31ra

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_001244207.1	Gene:	Il31ra / 688622	RGDID:	1586478	Length:	718	Species:	Rattus norvegicus

Alignment Length:	696	Identity:	153/696 - (21%)
Similarity:	247/696 - (35%)	Gaps:	171/696 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   834 EPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCV 898
            :|..:.|....::.:...|:...    ..||..||:| ...|.| .||.::..||.|.|....|
  Rat    23 KPENISCIFYFDRNLTCTWSPEK----ETNDTSYTVR-MTYSYG-KSSCTVNATEASCSFPSYC- 80

  Fly   899 ATNAFGSDDASINMIVQE------------------VPEMPYALKVLDKSGRSVQLSWAQPYDGN 945
               |...|:.|:.:..|.                  ..|.|..|.|...|.|..|:.| :|::..
  Rat    81 ---AIAPDNCSVEVEAQNNDGKAISAITYWDLSSIVKTEPPIILSVNPISNRMFQIRW-EPWEKI 141

  Fly   946 S--PLDRYIIEFKRSRAS-WSEI-----DRVIVPGHTTEAQVQKLSPATTY--NIRIVAENAIGT 1000
            .  || ..:|:|:...:| |:|:     :||.        .:..|...|.|  .:|....::...
  Rat   142 HVFPL-TCMIQFRTVNSSHWTEVNLEDCERVF--------NLTGLQAFTQYVLALRFRFSDSRYW 197

  Fly  1001 SQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMR---VTWKPPPRTEWNGEILGYYVGYKLSNTN 1062
            |:.|:..|.:|.||.|........:||.:....|   :.||.........:..||.:.|  |..|
  Rat   198 SKWSKEETRMTMEEVPHVLDLWRILEPADVNGDRKVLLLWKKARGAPVLEKTFGYNIQY--SAEN 260

  Fly  1063 SSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAG-------PLSEEEKQFTAEGT 1120
            |:.|.| ||.||.:    :.||  |.:...:.|.:.:||.:|..       |.:.||......|.
  Rat   261 STNVTE-INSITTQ----HYEL--LLLGQTHCVSVTSFNSLGKSQEAILRIPDAHEETFQCINGM 318

  Fly  1121 PSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVL 1185
            .:.         :....:.|.|     :|:...:.|:.|      ||..||..........::|
  Rat   319 QAY---------IAEPLLVVNW-----QSSIPEVDTWIV------EWIPETAESKFPALCWESV- 362

  Fly  1186 HGLKKYTNYTMQ---VLATTAGGDGVRSVPIHCQTEP------DVPEAPTDVKALVMGNAAI--- 1238
               .:.||:|::   :...|.....|..|..|...||      ...:|||......:.|..:
  Rat   363 ---SRVTNWTIEQDKLEPFTCYNISVYPVLGHHVGEPYSIQAYAKEKAPTSGPNTTVNNIGLKTA 424

  Fly  1239 LVSWR--PPAQPNGIITQYTVYSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTAST-- 1299
            :|:|:  |.:..||.|..||::.:|||.:..:||  |..:.:.::...|.:...|...|.|||
  Rat   425 VVTWKEIPKSIRNGFIHNYTIFYQAEGGKKLSKT--VNSHTLQYDLESLTRRTSYTVSVMASTRA 487

  Fly  1300 --TIGEGQQSKSIVAMPSDQVPAKIASFDDTF---------------TATF---KEDAKMPCLAV 1344
              |||.....|:          :.|:.|:...               |.||   |.::::..|..
  Rat   488 GGTIGSSINFKT----------SSISVFEIVLLTTLIGGGLLLLSIKTVTFGLRKPNSRLTHLCC 542

  Fly  1345 -GAPQPE----ITW---------KIKGVEFSANDRMRVLPDGSL--------------LIKSVNR 1381
             ..|.|.    .||         .:|..|.|.|...:||....:              .::.|:.
  Rat   543 PDVPNPAESSLATWFGDDFKKKSNMKETENSGNTEDQVLKPCPVPADLTDKLVVNFENFLEVVST 607

  Fly  1382 QDAGDYSCHAENSIAKDSITHKLIVLAPP----QSPHVTLSATTTD 1423
            .:||..........|.:.:|.......||    :.|.|...|.:.|
  Rat   608 AEAGKGQESVLGGEANEYVTSPSRADCPPGKSFKEPSVLTEAASED 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352
		IGc2	544..607	CDD:197706
		Ig	641..714	CDD:143165
		IGc2	735..804	CDD:197706
		I-set	819..914	CDD:254352	20/79 (25%)
		Ig	833..921	CDD:299845	22/104 (21%)
		FN3	918..1011	CDD:238020	25/102 (25%)
		FN3	1018..1116	CDD:238020	27/107 (25%)
		FN3	1124..1217	CDD:238020	17/95 (18%)
		FN3	1222..1312	CDD:238020	28/98 (29%)
		Ig	1339..1406	CDD:299845	16/94 (17%)
		FN3	1409..1499	CDD:238020	6/19 (32%)
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Il31ra	NP_001244207.1	FN3	116..205	CDD:238020	24/98 (24%)
Il31ra	NP_001244207.1	FN3	408..488	CDD:214495	23/81 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910