DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and PTPRM

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	XP_011524010.1	Gene:	PTPRM / 5797	HGNCID:	9675	Length:	1507	Species:	Homo sapiens

Alignment Length:	1448	Identity:	275/1448 - (18%)
Similarity:	428/1448 - (29%)	Gaps:	492/1448 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   649 DRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKTSMISIPSAS-------------------PA 694
            |.|.......:....|:.::||      |.:::.||...:||.|                   |.
Human    30 DEPYSTCGYSQSEGDDFNWEQV------NTLTKPTSDPWMPSGSFMLVNASGRPEGQRAHLLLPQ 88

  Fly   695 HTGRDT-CIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFP--------- 749
            ....|| ||..:      |.|....|.||..:              .|..|.:..|
Human    89 LKENDTHCIDFH------YFVSSKSNSPPGLL--------------NVYVKVNNGPLGNPIWNIS 133

  Fly   750 -KPQVTWKKA--VGDT--PGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSA 809
             .|..||.:|  ...|  |..|:.:              .:.|...::||...:.:..:|...:.
Human   134 GDPTRTWNRAELAISTFWPNFYQVI--------------FEVITSGHQGYLAIDEVKVLGHPCTR 184

  Fly   810 VIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIG-ILWNMN-NMRLDPKNDNRYTIREE 872
            .        |.|. :::|.....|:.|..||.|.|....| .||... ::|..|..:.:.|
Human   185 T--------PHFL-RIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVT---- 236

  Fly   873 ILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRS---V 934
             .|...::|.::..|.:.|:..:.|:.....|...::...:|.:.|.:|.|...|...|.:   :
Human   237 -SSRRFIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI 300

  Fly   935 QLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIV----AE 995
            ||: |...:|:.|:....:|:..:..||:  ||  .|..:|..::..|.|.|.|.|.::    .|
Human   301 QLN-ANSINGDGPIVAREVEYCTASGSWN--DR--QPVDSTSYKIGHLDPDTEYEISVLLTRPGE 360

  Fly   996 NAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSN 1060
            .  ||.....|:...|....|...|:.::|..|....:.:.|:|              .||.::.
Human   361 G--GTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEP--------------FGYNVTR 409

  Fly  1061 TNS--------------SYVFETINFITEEG-KEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSE 1110
            .:|              ..|.|.:::.||.. .:|.  :.||..||..||.:...|     |...
Human   410 CHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHT--ITNLSPYTNVSVKLILMN-----PEGR 467

  Fly  1111 EEKQ----FTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYA------PSD 1165
            :|.|    .|.|..|...|:::...:...:.|.:.|..|  ....|||..|::.|.      |..
Human   468 KESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREP--TQTYGVITLYEITYKAVSSFDPEI 530

  Fly  1166 EWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDG------------VRSVPIHCQTE 1218
            :..:::.|..|....:..:..||...|.|:..:.|:||.|.|            ..|:|.:   |
Human   531 DLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAY---E 592

  Fly  1219 PDVPEAPTDVKALVMGNAAILVSWRPPAQPNGI-ITQYTVYSKAEGAETETKTQK------VP-H 1275
            .:.|...||....||         ..||...|. ::.|.:..:.|......||.:      || |
Human   593 LETPLNQTDNTVTVM---------LKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIH 648

  Fly  1276 YQ------------MSFEATELEKNKPYE---------FWVT--------------ASTTIGEGQ 1305
            :|            ..|.|..|:..:|:.         :|.|              ||...||
Human   649 FQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGE-- 711

  Fly  1306 QSKSIVAMPSDQVPAKIASFDDTFTATF------KEDAKMPCLAVGAPQPE------ITWKIKGV 1358
                 ..:...||..|.|......|..:      ..|.::...|...|.||      .|.||.||
Human   712 -----TKIDCVQVATKAAIIVTQLTTPYIRIAPAAGDGQLTGAATPKPVPEPEKQTDHTVKIAGV 771

  Fly  1359 ------------------------------EFSANDRMRVL---PDGSLLIKSVNRQDAGDY--- 1387
                                          ..|....|.|:   .|.|...:..|..:|..:
Human   772 IAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDT 836

  Fly  1388 ---------------------SCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKP 1431
                                 |....||...|......|::......|...|.|::...:...|.
Human   837 HNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILVPINDETHTMASDTSSLVQSHTYKK 901

  Fly  1432 HEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILN 1496
            .|....|.....||          ..:.|.....:|..:.|...|     ||..
Human   902 REPADVPYQTGQLH----------PAIRVADLLQHITQMKCAEGY-----GFKE----------- 940

  Fly  1497 TRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNN 1561
                       |...|.|..|       ..|            :|.|:|:   |::.|..   .|
Human   941 -----------EYESFFEGQS-------APW------------DSAKKDE---NRMKNRY---GN 969

  Fly  1562 YVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRLPA---- 1622
            .:..|       :.|:......|.|.::|      :.|..|    ||....|.:...:.|.
Human   970 IIAYD-------HSRVRLQTIEGDTNSDY------INGNYI----DGYHRPNHYIATQGPMQETI 1017

  Fly  1623 ---WMPEWLDLNFMVPLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVYNQTMGPGAT 1684
               |...|.:....:.::..  :|.||....|    :...||     .::|.|:        ..|
Human  1018 YDFWRMVWHENTASIIMVTN--LVEVGRVKCC----KYWPDD-----TEIYKDI--------KVT 1063

  Fly  1685 LDKRRPDLRDEL--GYIAPPNRKLPPVPGSNYNTCDRIKRGRGGLRSNHSTWDPRRNPNLYEELK 1747
            |      :..||  .|:              ..|....|.|.||    .:...|.|.
Human  1064 L------IETELLAEYV--------------IRTFAVEKGGAGG----EANCSPSRE-------- 1096

  Fly  1748 APPVPMHGNHYGHAHGNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAG 1812
               |...|.|                   ||.....||..|:.:...|..|.....|..|.....
Human  1097 ---VSQRGVH-------------------EIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKS 1139

  Fly  1813 PVPGHAGTMLPPGHPGHVHSRSGSQ----------SMPRANRYQRKNSQGGQSSIYTPAPEYDDP 1867
            |         |...|..||..:|:.          .:..|.|       .|...||
Human  1140 P---------PSAGPLVVHCSAGAGRTGCFIVIDIMLDMAER-------EGVVDIY--------- 1179

  Fly  1868 ANCAEEDQYRRYTRVNSQ 1885
             ||..|.:.||...|.::
Human  1180 -NCVRELRSRRVNMVQTE 1196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352
		IGc2	544..607	CDD:197706
		Ig	641..714	CDD:143165	17/84 (20%)
		IGc2	735..804	CDD:197706	13/82 (16%)
		I-set	819..914	CDD:254352	21/96 (22%)
		Ig	833..921	CDD:299845	20/89 (22%)
		FN3	918..1011	CDD:238020	26/99 (26%)
		FN3	1018..1116	CDD:238020	23/116 (20%)
		FN3	1124..1217	CDD:238020	23/110 (21%)
		FN3	1222..1312	CDD:238020	26/132 (20%)
		Ig	1339..1406	CDD:299845	20/129 (16%)
		FN3	1409..1499	CDD:238020	14/89 (16%)
		FN3	1504..1584	CDD:238020	13/79 (16%)
		Dscam_C	1890..2008	CDD:289151
PTPRM	XP_011524010.1	MAM	22..182	CDD:214533	35/191 (18%)
		MAM	27..182	CDD:99706	35/191 (18%)
		IG_like	192..278	CDD:214653	19/90 (21%)
		ig	192..274	CDD:278476	19/86 (22%)
		FN3	282..361	CDD:214495	21/83 (25%)
		FN3	383..477	CDD:238020	23/114 (20%)
		FN3	499..581	CDD:238020	20/83 (24%)
		PTPc	937..1208	CDD:214550	75/423 (18%)
		PTPc	964..1208	CDD:238006	64/352 (18%)
		PTPc	1240..1502	CDD:214550
		PTPc	1270..1502	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910