DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam1 and PTPRK

DIOPT Version :9

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:NP_001278910.1 Gene:PTPRK / 5796 HGNCID:9674 Length:1462 Species:Homo sapiens


Alignment Length:1278 Identity:241/1278 - (18%)
Similarity:400/1278 - (31%) Gaps:442/1278 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   763 PGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRN 827
            |.||:.:.:::......|.:.:|:||..:   |.|:                  ..|.|. :|.:
Human   161 PNEYQVIFEAEVSGGRSGYIAIDDIQVLS---YPC
D------------------KSPHFL-RLGD 203

  Fly   828 QTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIRE--EILSTGVMSSLSIKRTERS 890
            .....|:.|..||.|.|...:     .|.:.|..:|.....:.:  .|......:|..::...::
Human   204 VEVNAGQNATFQCIATGRDAV-----HNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKT 263

  Fly   891 DSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRS---VQLSWAQPYDGNSPLDRYI 952
            |..|:.||..:..||..::...::...|..|.|...|...|.:   :||: |....|:.|:....
Human   264 DQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLN-ANSIIGDGPIILKE 327

  Fly   953 IEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIV----AENAIGTSQSSEAVTIITAE 1013
            :|::.:..||:|...|..|.:    ::..|.|.|.|.||::    .|.  ||......:...|..
Human   328 VEYRMTSGSWTETHAVNAPTY----KLWHLDPDTEYEIRVLLTRPGEG--GTGLPGPPLITRTKC 386

  Fly  1014 EAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFE-TINFITEEG 1077
            ..|...|:.:|:..:....:.|.|          |.|||       |....:.|. ||.:....|
Human   387 AEPMRTPKTLKIAEIQARRIAVDW----------ESLGY-------NITRCHTFNVTICYHYFRG 434

  Fly  1078 KEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGW 1142
              ||                             |.|....:..|..|                  
Human   435 --HN-----------------------------ESKADCLDMDPKAP------------------ 450

  Fly  1143 VSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDG 1207
                                          :|         |::.|..|||.:::::.|...|..
Human   451 ------------------------------QH---------VVNHLPPYTNVSLKMILTNPEGRK 476

  Fly  1208 VRSVPIHCQTEPDVPEAPTDVKALVMGNA---AILVSWRPPAQPNGIITQYTV-YSK-------- 1260
            .....| .||:.||| .|..||:| .|.:   .|.::|:.|..||||||||.: ||.        
Human   477 ESEETI-IQTDEDVP-GPVPVKSL-QGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAV 538

  Fly  1261 --AEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSK-------SIVAMPS- 1315
              |...:|.:......|:..    ..|.....|:|::.|||..|.|..:.       |...:|. 
Human   539 PVAGPPQTVSNLWNSTHHVF----MHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDY 599

  Fly  1316 DQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVN 1380
            :.|.|.:.....|.|...:     |..|.|||            .||.         .::::.::
Human   600 EGVDASLNETATTITVLLR-----PAQAKGAP------------ISAY---------QIVVEELH 638

  Fly  1381 ----RQDAGDYSCHA-----ENSIAKDSITHKLIVLAP---PQSPHVTLSATTTDALTVKLKPHE 1433
                :::||...|:.     :|:::..:..:....|.|   |:....|:....|         ::
Human   639 PHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRT---------YQ 694

  Fly  1434 G----DTAPLHGYTLHYK-----------------PEFGEWETSEVSVDSQKH-----NIEGLLC 1472
            |    ..||..||.::::                 .:....|..||..|..|.     .|.|:..
Human   695 GFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISA 759

  Fly  1473 GSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHF 1537
            |....:..             :|......:|.||.:|.:  :...|:..           .|:|.
Human   760 GILVFILL-------------LLVVILIVKKSKLAKKRK--DAMGNTRQ-----------EMTHM 798

  Fly  1538 V--VESKKRDQ-------------IEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHNSAGFTV 1587
            |  ::....||             ::.:..|..:..|.......|.|.|..|...||.:|....|
Human   799 VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLVPITDENHSATAESSRLLDV 863

  Fly  1588 AEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRLPAWMPEWLDLNFMVPLIATVVVVAVGICVVCV 1652
            ..|      :..||.:|...    |.:|..||:...:..   :|.|                   
Human   864 PRY------LCEGTESPYQT----GQLHPAIRVADLLQH---INLM------------------- 896

  Fly  1653 ALSRRRADDMRGGQKDVYYDVVYNQTMGPGATLDKRRPD---LRDELGYIAPPNRK---LPPV-- 1709
                 :..|..|.:::  |:..:.   |..|:.|..:.|   .::..|.|...:..   |.||  
Human   897 -----KTSDSYGFKEE--YESFFE---GQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVED 951

  Fly  1710 -PGSNYNTCDRIKRGRGGLRSNH-STW---DPRRNPNLYEELKAPPVPMHGNHYGHAH------- 1762
             |.|:|            :.:|: ..|   |..:.|:.|   .|...|:|...|....       
Human   952 DPSSDY------------INANYIDIWLYRDGYQRPSHY---IATQGPVHETVYDFWRMIWQEQS 1001

  Fly  1763 ------------GNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFP---------- 1805
                        |..:|:...|   |:...|..|.:...  ||:|......:||.          
Human  1002 ACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCV--EMEPLAEYVVRTFTLERRGYNEIR 1061

  Fly  1806 -----HQNG---HAGPVPGHAGTML-----------PPGHPGHVHSRSGSQSMPRANRYQRKNSQ 1851
                 |..|   |.  ||.||..:|           |...|..||..:|:               
Human  1062 EVKQFHFTGWPDHG--VPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGA--------------- 1109

  Fly  1852 GGQSSIYTPAPEYDDPA---------NCAEEDQYRRYTRVNSQ 1885
             |::..|.......|.|         ||.:..:.||...|.::
Human  1110 -GRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTE 1151

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 Ig 38..130 CDD:299845
IG 57..133 CDD:214652
IG_like 267..343 CDD:214653
Ig 269..340 CDD:143165
IG_like 353..425 CDD:214653
IGc2 361..413 CDD:197706
I-set 433..527 CDD:254352
IGc2 446..517 CDD:197706
I-set 533..618 CDD:254352
IGc2 544..607 CDD:197706
Ig 641..714 CDD:143165
IGc2 735..804 CDD:197706 9/40 (23%)
I-set 819..914 CDD:254352 20/96 (21%)
Ig 833..921 CDD:299845 18/89 (20%)
FN3 918..1011 CDD:238020 25/99 (25%)
FN3 1018..1116 CDD:238020 17/98 (17%)
FN3 1124..1217 CDD:238020 10/92 (11%)
FN3 1222..1312 CDD:238020 31/110 (28%)
Ig 1339..1406 CDD:299845 11/75 (15%)
FN3 1409..1499 CDD:238020 18/118 (15%)
FN3 1504..1584 CDD:238020 18/94 (19%)
Dscam_C 1890..2008 CDD:289151
PTPRKNP_001278910.1 MAM 32..192 CDD:214533 8/33 (24%)
IG_like 202..288 CDD:214653 17/90 (19%)
fn3 297..371 CDD:365830 19/78 (24%)
fn3 488..581 CDD:365830 31/98 (32%)
PTP_DSP_cys 888..1166 CDD:391942 59/334 (18%)
Substrate binding. /evidence=ECO:0000250 1105..1111 1/21 (5%)
R-PTPc-K-2 1252..1457 CDD:350484
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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