DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and kirrel3b

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	XP_021323594.1	Gene:	kirrel3b / 572369	ZFINID:	ZDB-GENE-100713-3	Length:	795	Species:	Danio rerio

Alignment Length:	819	Identity:	166/819 - (20%)
Similarity:	281/819 - (34%)	Gaps:	193/819 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   434 VIRQAFQEETMEPGPSVFLKC-VAGGNPTPEISWELD------GKKIANNDRYQVGQYVTVNGDV 491
            |..|..|:..:..|..|.|.| :.|.:..  :.|..|      |:.::...||.|   |..:|..
Zfish    30 VFSQQPQDLVVVAGQPVTLPCSIPGYHGV--VLWLRDGLALGVGRDLSGYPRYAV---VGDHGSG 89

  Fly   492 VSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVY---------GLPYIRQMEKKAIVAGETL 547
            ..:|.|..|...|..:::|.| .:..:....|:|.|.         |.|.:      ::.||:.|
Zfish    90 EHHLRIQKVELMDDAVFECQA-IQAAMRSRPARLTVLVPPDDPMITGGPVV------SLRAGDPL 147

  Fly   548 IVTCPV-AGYPIDSIVWERDNRALPINRKQKVFPNGTL----IIENVERNSDQATYTCVAKNQE- 606
            .:||.. ...|..||:|.|:...|          ||.:    ::.:..|.|..:|....|.|.|
Zfish   148 NLTCHADNAKPAASIIWIRNGEVL----------NGAMYSKTLLRDGRRESTVSTLYISASNIES 202

  Fly   607 ---------GYSARGSLEVQVMVLPQIVPFAYEDLINM---------GDSIDLFCQIQKGDRPIK 653
                     ..:.....|..|.:..|.:|     |:|:         |:.:...|..:......:
Zfish   203 GQKIICRASNKAVPNGKETSVTIDIQHLP-----LVNLSVEPQPVLEGNLVKFHCSAKANPPVTQ 262

  Fly   654 VHWS-----FERSAGDYGFDQVQPQMRTNRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYS 713
            ..|:     .:..:||           |..:....|..:.|.         :|..:|..|:|..|
Zfish   263 YKWAKGGSVIKEVSGD-----------TYEVIVDHSFFTEPV---------SCEVTNPLGSTNIS 307

  Fly   714 VDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVE 778
            .::.|...||...||.......||||...|...|.|...:.|.|            :.|..:...
Zfish   308 RNVDVYFGPRMAAEPQSLQVDLGSDAVFNCAWTGNPSLTIVWMK------------RGSGVVLSN 360

  Fly   779 EGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAK 843
            |..|.:.::::.:.|.|:|.|:..........:.::|..||..:....:| |..||...::|..:
Zfish   361 ENILTLKSVRQEDAGKYVCRAVVPRVGAAEKEVSLTVNGPPTISSTQTHQ-APHGEKGQIKCFIR 424

  Fly   844 GEKPIG-ILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSD-SALFTCVATNAFGSD 906
            ...|.. |.|:.....|:.....|||:.......||:|:|::.....:| ..::.|.|.|:||||
Zfish   425 STPPPDRIAWSWKETVLESGTSGRYTVETVSTEDGVLSTLTMSNIVPADFQTIYNCTAWNSFGSD 489

  Fly   907 DASINMIVQ--EVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYII-------------EFK 956
            ...|.:..|  ....:|.|:.:....|..|               .:|:             :.|
Zfish   490 TEIIRLKEQGGSQDSLPVAVIIGVAVGAFV---------------AFIVLMGTIGAFCCTRSQRK 539

  Fly   957 RSRASWSEIDRVIVPGHTTE--AQVQKL-SPATTYNIR--IVAENAIGTSQSSEAVTIITAEEAP 1016
            :|....:|...:::|...|.  ||.::| |...|.|::  :.|:|.|......:........|..
Zfish   540 KSAHLCTEDAHLVMPTLPTSICAQQRELASKIKTENLKGVVSAKNDIRVEIVHKDHNAARESEEH 604

  Fly  1017 SGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHN 1081
            ||..| :.:|               |.|:..|                .|.:.:..:.||.||:
Zfish   605 SGMKQ-LMIE---------------RGEFQQE----------------SVLKQLEVLQEEEKEY- 636

  Fly  1082 LELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPP 1146
               |:::..|.....:..|.:....|.:....|.|      :...|.|..|...|.:..|.
Zfish   637 ---QHIKDPTNGYYSVNTFKEHHGTPTTMAGNQTT------ELRRDPATATTGKQRVPTGM---- 688

  Fly  1147 LESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVL 1185
                 .....|..:.|..:..||.::|......||...|
Zfish   689 -----SFTNIYSTLGAGPNRLYDYSQRFVLGMGSSSIEL 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352	24/99 (24%)
		IGc2	446..517	CDD:197706	19/77 (25%)
		I-set	533..618	CDD:254352	20/99 (20%)
		IGc2	544..607	CDD:197706	18/77 (23%)
		Ig	641..714	CDD:143165	11/77 (14%)
		IGc2	735..804	CDD:197706	16/68 (24%)
		I-set	819..914	CDD:254352	26/96 (27%)
		Ig	833..921	CDD:299845	24/91 (26%)
		FN3	918..1011	CDD:238020	19/110 (17%)
		FN3	1018..1116	CDD:238020	16/97 (16%)
		FN3	1124..1217	CDD:238020	13/62 (21%)
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
kirrel3b	XP_021323594.1	IG_like	35..124	CDD:214653	22/94 (23%)
		Ig2_KIRREL3-like	146..227	CDD:143236	19/90 (21%)
		Ig_2	235..312	CDD:316418	13/96 (14%)
		I-set	316..397	CDD:333254	20/92 (22%)
		Ig5_KIRREL3	399..496	CDD:143306	27/97 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10962
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000