DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and igsf9bb

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	XP_009293693.1	Gene:	igsf9bb / 569554	ZFINID:	ZDB-GENE-091112-15	Length:	1439	Species:	Danio rerio

Alignment Length:	1429	Identity:	298/1429 - (20%)
Similarity:	512/1429 - (35%)	Gaps:	383/1429 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 SVGGESVETVLTVTAPLSAKIDPP--TQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPV 393
            |..||:|.....|..||:.:   |  .:...||.|..|...:...| ..|.....|:|..|.:..
Zfish    35 SRAGETVILGCDVVHPLNGQ---PYVVEWFKFGVPIPFFINFRFYP-PHVDPEYAGRASLHGKSS 95

  Fly   394 LRIESVKKEDKGMYQC---FVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCV 455
            ||||.|:.||:|.|:|   .:.....:....:.:.|.....|.......|....:.|.|:.|.|.
Zfish    96 LRIERVRSEDQGWYECKVLMLEQQYHTFHNGSWVHLTVNAPPTFTDTPPQYVEAKEGGSITLSCT 160

  Fly   456 AGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAE 520
            |.|||.|.:||..:|..:.::.:|:|..         ..|.:.|:...|.|.|.|.|.|:.|.|.
Zfish   161 AFGNPKPSVSWLREGNPVQDSTKYKVSD---------GSLTLVSISREDRGAYTCRAYSEQGEAV 216

  Fly   521 HSAKLNVYGLPYI-RQMEKKAIVAGETLIVTCPVAGYPID---SIVWERDNRAL--PINRKQKVF 579
            |:.:|.|.|.|:| ...|...:...:....||....||.:   :..||.||...  .:.|:..:.
Zfish   217 HTTRLLVQGPPFIVSPPENITVNISQDAFFTCQAEAYPGNLTYTWFWEEDNVFFKNDLKRRVSIL 281

  Fly   580 PNGTLIIENVERNSDQATYTCVAKNQEGY--SARGSLEV----QVMVLPQIVPFAYEDLINMGDS 638
            .:|:|||..| :..|...|||...|..|.  ||...|.|    :|:.:|.::      .:.:|..
Zfish   282 IDGSLIISQV-KPEDAGKYTCSPSNSLGRPPSASAYLTVHYPARVINMPPVI------YVAIGLP 339

  Fly   639 IDLFCQIQKGDRPIKVHWSFE----RSAGDYGFDQVQP-QMRTNRISEKTSMISIPSASPAHTGR 698
            ..:.|.:........|.|..:    |.....|:.|::. .:|.:.::|.:            .|.
Zfish   340 GYIRCPVDANPPVTSVKWKKDGLPLRIEKYPGWSQMEDGSIRVSEVTEDS------------LGT 392

  Fly   699 DTCIASNKAGTTTYS--VDLTVNVPPRWILEPTDKAFAQ--GSDAKVECKADGFPKPQVTWKKAV 759
            .||:..|..||...|  ..|.:..||::::.|..: :.|  |.:..:.|:|:|.|.|.:||:|.|
Zfish   393 YTCVPYNSLGTMGPSPPAPLVLKDPPKFLVVPGGE-YRQEAGRELVIPCEAEGDPFPNITWRKKV 456

  Fly   760 GDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSA-----VIMISVQAPP 819
            |      |..:...|: :..|:|...::.|.:.|.:.|.|.| :.:.::|     ||..|..||.
Zfish   457 G------KPSRSKHNV-LPRGSLQFKSLSKEDHGEWECVASN-VATSITASTHLLVIGTSPHAPA 513

  Fly   820 EFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTI-------REEI---- 873
            :....:...:|                  .:.|:.:   .|...:..:::       ||::
Zfish   514 KVHVTVSTTSA------------------NVSWDSS---YDGGFEQTFSVWYGHVVKREQLGPHD 557

  Fly   874 -LSTGVMSS---LSIKRTERSDSALFTCVATNAFG----SDDASINMIVQEV--PE-----MPYA 923
             ||..|.|.   |.::..|...:..|:.:|.|..|    |:..::|.:|..:  ||     .|..
Zfish   558 WLSMPVPSGQHWLLVQGLEPETAYQFSVLAQNKLGTGPFSEVVTVNTLVFPISTPEPLVLLTPPR 622

  Fly   924 LKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTY 988
            ....:::.:.|.|:|..|.:..||:|.||::| |....|..:|..| |...||...:.|.....|
Zfish   623 CLTANRTQQGVLLTWIPPANHTSPIDHYIMDF-RLGERWDVLDDAI-PAGETEILARDLIQEAWY 685

  Fly   989 NIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYY 1053
            ..|::|......|:.|..|.:.:.:                       :.|||.....|
Zfish   686 EFRVMAVMEDLVSEPSNVVGVSSTD-----------------------YFPPPEVPDEG------ 721

  Fly  1054 VGYKLSNTNSSYVFETINFITEE-----------GKEHNLELQNLRVYTQYSVVIQAFNKIGAGP 1107
                |:....:.:..||.|:...           .|:...:|:..|                ..|
Zfish   722 ----LARPVVAGIVATICFLAAAILFSTLAACFVNKQRRRKLKRRR----------------DPP 766

  Fly  1108 LSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDE---WYD 1169
            ||....:.:.| |||      :...::.::||.  :.||.||:...::..|...:|:.|   .|.
Zfish   767 LSITHCRKSVE-TPS------SSGKISPESIRS--IGPPSESSEDGLRAKKFPQSPAKEELSLYK 822

  Fly  1170 ETKRHYKKTASSDTVLHGLKKYTNYTMQVLATT------AGGDGVRSV--PIHCQT--------- 1217
            :|||         .::.  |||:....:..|||      .|.|| |.|  |...:|
Zfish   823 KTKR---------AIIS--KKYSVSKHEAEATTPIELISRGPDG-RFVMDPTDMETPVKARRIEG 875

  Fly  1218 ------------------EPDVPEAPTDVKALVMGNAAILVS------WRPPA------QP-NGI 1251
                              |.|.|.....|.|.:..:....:|      .:|||      :| .|:
Zfish   876 FPFVEESDLYPEFRQSDEENDDPGPMPPVMATLRPHQISPISSSQESYLQPPAYSPRFQRPMEGM 940

  Fly  1252 ITQYTVYSKAEGAETETKTQKVPHYQ-------MSFEATELEKNKPYEFWVTASTTIGEGQQSKS 1309
            ....|...:|.|     :.:..||::       .|:..:..|...|..|::..::.:      .|
Zfish   941 TIMETSRLQATG-----QIRGAPHFRAFTHGQFYSYLGSPGEPEPPPPFYMPDTSPL------SS 994

  Fly  1310 IVAMP---------SDQVPAKI--------ASFDDTFTATFKEDAKMPCLAVGAPQPEITW-KIK 1356
            :::.|         ...:|.:|        |....|........::.|.:   ..:|:.|: .|:
Zfish   995 VMSSPPYHLEGPFGHPTIPEEIGEGEIQHYAVSGYTLPLAHPSTSRSPDI---WQRPDFTFATIE 1056

  Fly  1357 GVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATT 1421
            |..|       :.|....|            ..|.|                ||..|.:.|..:.
Zfish  1057 GPHF-------IFPPPHPL------------HLHPE----------------PPLPPPLVLPPSA 1086

  Fly  1422 TDALTVKLKPHEGD---TAPLHGYTLHYKPEFGEWETSEV----------------SVDSQKHNI 1467
            ....|:::.|:.|.   .||        |...|: ..|:|                |:...:|..
Zfish  1087 LQPSTLQVSPYPGILQLEAP--------KSRPGK-SPSKVKPQGLPAKRLPMQEAQSLGQLRHTS 1142

  Fly  1468 EGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKL-PEKPRFIE-------------VSSN 1518
            .|:  |.....|....:::....:...|:||.....|:| |.:||.:|             ::.:
Zfish  1143 HGM--GVPVLPYPDPVSHMVGPSSFGSLDTRWYELTPRLSPRQPRRMEPSMVVLQPSRLSPLTQS 1205

  Fly  1519 SVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHNS 1582
            .:|.|      .|.|  ..||..:.|.    :.|...:.|:.:.:.|....:..::.|.:..:|
Zfish  1206 PISSH------EGSP--EIVVRPRPRP----SMIQPPIPPEMSEITLQPPSSASFSRRSSPSSS 1257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653	4/11 (36%)
		Ig	269..340	CDD:143165	4/8 (50%)
		IG_like	353..425	CDD:214653	20/76 (26%)
		IGc2	361..413	CDD:197706	18/54 (33%)
		I-set	433..527	CDD:254352	27/93 (29%)
		IGc2	446..517	CDD:197706	22/70 (31%)
		I-set	533..618	CDD:254352	26/96 (27%)
		IGc2	544..607	CDD:197706	19/67 (28%)
		Ig	641..714	CDD:143165	15/79 (19%)
		IGc2	735..804	CDD:197706	21/70 (30%)
		I-set	819..914	CDD:254352	17/113 (15%)
		Ig	833..921	CDD:299845	19/113 (17%)
		FN3	918..1011	CDD:238020	27/97 (28%)
		FN3	1018..1116	CDD:238020	14/108 (13%)
		FN3	1124..1217	CDD:238020	25/103 (24%)
		FN3	1222..1312	CDD:238020	19/109 (17%)
		Ig	1339..1406	CDD:299845	10/67 (15%)
		FN3	1409..1499	CDD:238020	20/108 (19%)
		FN3	1504..1584	CDD:238020	18/93 (19%)
		Dscam_C	1890..2008	CDD:289151
igsf9bb	XP_009293693.1	IG_like	30..113	CDD:214653	27/81 (33%)
		Ig	41..113	CDD:143165	24/75 (32%)
		IG_like	144..223	CDD:214653	27/87 (31%)
		IGc2	151..208	CDD:197706	20/65 (31%)
		I-set	227..319	CDD:254352	26/92 (28%)
		Ig	<263..319	CDD:299845	19/56 (34%)
		Ig_2	326..414	CDD:290606	18/105 (17%)
		IG_like	329..403	CDD:214653	14/91 (15%)
		IG_like	424..504	CDD:214653	23/88 (26%)
		Ig	440..504	CDD:299845	20/71 (28%)
		FN3	509..604	CDD:238020	18/115 (16%)
		FN3	620..704	CDD:238020	24/85 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000