DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and lrit3a

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_001122166.1	Gene:	lrit3a / 558559	ZFINID:	ZDB-GENE-080723-63	Length:	636	Species:	Danio rerio

Alignment Length:	648	Identity:	132/648 - (20%)
Similarity:	208/648 - (32%)	Gaps:	227/648 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 TGETRLSATKGRLVITEPVGSVSPQLSGNGNQEHITLTRVPKMGSVTLMCPAQAY---------- 278
            |.:.|:..|..|.|.||....:|       ...::.:|    ..|:|.:.|...|
Zfish    59 TVKLRVEKTAVRRVPTEAFYYLS-------ELRYLWIT----YNSITSVDPGSFYNLKVLHELRL 112

  Fly   279 ---PVPFFRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETV 340
               .:..|.|....|..:.|...:.|:|:..|.    ::.|....:..||.:.:|.:
Zfish   113 DGNMIATFPWESLKEMPSLKTLDLHNNRLTSVP----VEAAPYLINITYLDISSNKL-------- 165

  Fly   341 LTVTAPLSAKID--PPTQTVDFGRPAVFTCQYTGNPIKTVSWMKD---GKAIGHSE----PVLRI 396
              .|.| |..:|  ||...:   :|:..|.|.|...::...|..|   .|.|..|:    ||:.:
Zfish   166 --TTLP-SDLVDIWPPFSGI---QPSANTSQKTVLGLQDNPWYCDCRISKLIELSKMAGIPVVLM 224

  Fly   397 ESV-----KKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVA 456
            :.|     .:...|:  .|.|     ||....:|       |.:..:..:.|...|.:|.|:|.|
Zfish   225 DQVLTCSGPEHLSGV--LFQR-----AELDQCVK-------PTVMTSATKITSPLGSNVLLRCDA 275

  Fly   457 GGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVV--SYLNITSVHANDGGLYKCIAKSKVGVA 519
            .|.|||.:.|......:.||...|...     |:.|  |.|::.|:...|.|.|:|.||:..|.|
Zfish   276 NGFPTPTLLWTTADGSVVNNTVVQESP-----GEGVRWSILSLHSIVFKDAGDYRCKAKNVAGNA 335

  Fly   520 EHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPIN-RKQKVFPNGT 583
            |....|:|.|:.                    |...:|             ||| .||.
Zfish   336 EAYITLSVDGVQ--------------------PTTPFP-------------PINITKQP------ 361

  Fly   584 LIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVM-VLPQIVPFAYEDLINMGDSIDLFCQIQK 647
                     .||.|.|........:::...:.:... |:..:.|.........|..      :|:
Zfish   362 ---------EDQPTTTFTPTKMPLFTSLSPITITTRPVMTTMPPLTTRKSPIPGGG------VQR 411

  Fly   648 ----GDRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKTSMISIPSASPAHTGRDTCIASNKAG 708
                ||:|.||.                 |.:..:.|.|.|.|           ||..:...
Zfish   412 SPPAGDKPAKVQ-----------------QSKNGKGSIKKSDI-----------RDIEVVEE--- 445

  Fly   709 TTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDT-------PGEY 766
            ||..:|.|       |                   .|:|.|          .||       |.:.
Zfish   446 TTETAVLL-------W-------------------SAEGLP----------SDTPLTVVYFPYDA 474

  Fly   767 KDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIG---------------SGLSAVIMIS 814
            ||.|::.:..|.:|.|.::.:. .|:.|.:|......|               .|.:.|:||:
Zfish   475 KDDKETVDTEVGQGKLLLEYLM-PNQVYTVCLVTKSSGKEQCVDFSTLEIGGEEGQNKVLMIA 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653	15/88 (17%)
		Ig	269..340	CDD:143165	14/83 (17%)
		IG_like	353..425	CDD:214653	19/83 (23%)
		IGc2	361..413	CDD:197706	14/63 (22%)
		I-set	433..527	CDD:254352	30/95 (32%)
		IGc2	446..517	CDD:197706	24/72 (33%)
		I-set	533..618	CDD:254352	11/85 (13%)
		IGc2	544..607	CDD:197706	11/63 (17%)
		Ig	641..714	CDD:143165	15/76 (20%)
		IGc2	735..804	CDD:197706	15/75 (20%)
		I-set	819..914	CDD:254352
		Ig	833..921	CDD:299845
		FN3	918..1011	CDD:238020
		FN3	1018..1116	CDD:238020
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
lrit3a	NP_001122166.1	LRR_8	81..141	CDD:290566	11/70 (16%)
		leucine-rich repeat	83..106	CDD:275378	5/26 (19%)
		LRR_4	107..145	CDD:289563	6/37 (16%)
		leucine-rich repeat	107..130	CDD:275378	3/22 (14%)
		LRR_8	129..>171	CDD:290566	10/56 (18%)
		LRR_4	129..170	CDD:289563	10/55 (18%)
		leucine-rich repeat	131..154	CDD:275378	5/26 (19%)
		leucine-rich repeat	155..168	CDD:275378	3/22 (14%)
		TPKR_C2	199..249	CDD:301599	13/56 (23%)
		Ig	252..343	CDD:299845	30/95 (32%)
		IG_like	261..343	CDD:214653	29/86 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900