DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and sdk1b

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	XP_017211454.1	Gene:	sdk1b / 555553	ZFINID:	ZDB-GENE-090311-17	Length:	2292	Species:	Danio rerio

Alignment Length:	1635	Identity:	381/1635 - (23%)
Similarity:	597/1635 - (36%)	Gaps:	441/1635 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 TAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLR--IESVKKEDKGM 406
            |||.........||...|...|.||...|:......||::...|....|..|  |.|:|:||.|:
Zfish   167 TAPYFKTETGGAQTHLEGNRLVLTCLAEGSWPLEFKWMRNSTDITEYTPEYRYTIVSLKREDAGV 231

  Fly   407 YQCFVRNDQESAEASAELKLGG----RFDPPVIRQAF--------QEETMEPGPSVFLKCVAGGN 459
            |||.|||           ::|.    |.|   :|.|:        |.:|:..|.:..|...|..:
Zfish   232 YQCAVRN-----------RMGALIQTRAD---VRVAYMDNFAELEQRKTVSQGRAAVLNPPAVTS 282

  Fly   460 -PTPEISWELDGKKIANNDRYQV----------------GQYVTV-----NGDVVS----YLNIT 498
             |.|:::|..||.||..|.|..:                |:|...     ||:..:    ||:|.
Zfish   283 FPRPQVTWFRDGVKIIPNHRVAITLDNQLVVLSTAAADAGRYYVQAVNERNGENKTSPSIYLSIA 347

  Fly   499 SVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKK-AIVAGET-LIVTCPVAGYPID-- 559
            ....|.|.|...||.::: ||           |.|....|. ::|||.: ..:.|......:|
Zfish   348 INKRNRGSLADVIAPAEL-VA-----------PVIVIAPKNTSVVAGASEATLECVANARSLDRL 400

  Fly   560 SIVWERDNRAL-----PINRKQKVFPNGTLIIENVERNSDQATYTCVA--KNQEGYSARGSLEVQ 617
            .:.|:|:...|     ...|:        |:|.| ..::|...|.|.|  :|....|......:.
Zfish   401 QVFWKRNGVRLTAGVDSFGRR--------LVISN-PTSADGGLYVCEATLRNSSQKSTEAKAYLS 456

  Fly   618 VMVLPQIV--PFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERSAGDYGFDQVQPQMRTN--- 677
            |:..|...  |..|. :..:..:::|.|. .||....|:.|          |....|....|
Zfish   457 VLESPHFTSKPKRYM-IAEVEKNVELQCH-AKGVPTPKLEW----------FKDAIPLSTLNNSR 509

  Fly   678 -RISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTV-NVPPRWILEPTDKAFAQGSDAK 740
             :::..:.::.:....|...|...|.|.|.||......:|.: ::.|.:...|:|.....|:.|.
Zfish   510 YKLTTSSMVLQVRRIQPDDAGIFQCFAENTAGEIQAHTNLVITSMSPLFTTPPSDITVTDGTSAV 574

  Fly   741 VECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIR------VEEGTLHVDNIQKTNEGYYLCEA 799
            ..|...|.|||.:.|:|.        ..:..|.:::      :|.|.|.:..|..::.|.|.|.|
Zfish   575 FTCDTSGAPKPAIVWRKG--------SQVLASGSVQTPRFTLLESGGLQILPIMPSDAGNYTCLA 631

  Fly   800 IN--GIGSGLSAVIMIS---VQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGI--LWNMNNM 857
            .|  |:.:...|:.::|   :..|||      :|...:|..|||.|.|..:..:.:  .|.....
Zfish   632 SNTEGLVNATVALTVLSRTFISTPPE------DQRVIKGTTAVLHCAATHDPRVTVRYSWKKGTK 690

  Fly   858 RLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPY 922
            .|......|.:::|        .||.|.:|...|...:||...:..|:|..|..:.|.|:|..|.
Zfish   691 PLSVSTGGRVSMKE--------GSLQISQTWSGDIGDYTCRVISPAGNDSKSARLEVIELPHSPR 747

  Fly   923 ALKVL--DKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQ--VQKLS 983
            .|:|.  :...|:|.|||.:|:||||||..|||||..:.:.|......:.|   |.|.  |..|:
Zfish   748 NLQVALNETDSRTVLLSWVRPFDGNSPLLHYIIEFSENNSPWKVYMDDVSP---TLASLLVIGLT 809

  Fly   984 PATTYNIRIVAENAIGTSQ-SSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNG 1047
            ||.||..|:.|.|.:|..| |:|...::..||.||..|:||........::.|.|:|||..:.||
Zfish   810 PARTYQFRVCAVNQVGRGQYSAETNRLMLREEPPSAPPKNIVASGRTNQSIMVQWQPPPEPQLNG 874

  Fly  1048 EILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLEL-QNLRVYTQYSVVIQAFNKIGAGPLSEE 1111
            .:.||.:.|:|:.....:..:.|.     ..|.|..| ..|.::|||.:.:.|:...|.|..|:.
Zfish   875 VLRGYVLRYRLAGLPGEFQLKNIT-----SAEINYCLIGELIIWTQYEIQVAAYTGAGLGVYSQS 934

  Fly  1112 EKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAP------------S 1164
            ..::|.:|.|:.||.|.....|.|.||:..|..||.:..||:.:.||::..|            :
Zfish   935 ATEYTLQGVPTAPPQDVEAVALNSTTIKFTWTPPPQQFINGINQGYKLLVWPEHCPDCITMVTIA 999

  Fly  1165 DEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVK 1229
            .|::.  .|||...::       |:|:|.|...||..|..|||..|.....||..|.|...|.:.
Zfish  1000 PEFHG--SRHYGYVSN-------LRKFTWYETAVLCFTTPGDGPASTSQLIQTHVDKPGPVTQLS 1055

  Fly  1230 ALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAETET-KTQKVPHYQMSFEATELEKNKPYEF 1293
            ...:.:.::.:||:.|...|||||.| |.|..|..:.|| .:|.:.:..::::.|.|.....|..
Zfish  1056 FTEILDTSLRISWQEPEDKNGIITGY-VLSWQEAGQNETLVSQTLSNSTLAYKVTGLTSLTTYAL 1119

  Fly  1294 WVTASTTIGEGQQSKSIVA---------MPSDQVPAKIASFDDTFTATFKEDAKM---------P 1340
            .|.|.|..|.|..:.|.::         .||:.|.:.|:....|...:...|.|.         .
Zfish  1120 QVAAVTQAGVGASTSSTISTGLPPELPGAPSNLVISNISPRSVTIQFSPGSDGKTEISKWIVEGQ 1184

  Fly  1341 CLAVGAPQPEITWKI-------------------------------------------------- 1355
            .:.||..:.|..||:
Zfish  1185 VVIVGEEEKEAEWKVLYERDSPPASDTLEIPNLIPFTQYRFRMKQVNIVGSSPFSESSRLMQTLQ 1249

  Fly  1356 --------KGVEFSAND-----RMRVLP------------------------------------- 1370
                    :.|.|||::     |...||
Zfish  1250 SSPDVAPTELVVFSASETSLRIRWEPLPEAAYNGNPESVGYRVRAQRADGFGQPRMETVSDRLSC 1314

  Fly  1371 -----------DGSLLIKSVNRQDAGDYSCHA-------------ENSIA--------------- 1396
                       |..|.|::.|....|.:|.|.             ||..|
Zfish  1315 EVTVEGLEEWTDYELSIQAFNSIGPGPWSSHVLGKTKESVPSGAPENVSAEAMSSTSVLVTWGSV 1379

  Fly  1397 ------------------KDS------------ITHKLI-------------VLA-------PPQ 1411
                              |||            .||.|:             |||       ||.
Zfish  1380 PEHQKNGHILGYKVLYREKDSDRAPQAHLVNGNQTHMLLLRNLSKFTVYEIQVLAFTRVGDGPPS 1444

  Fly  1412 SPHVTLSATTTD----------------ALTVKLKPHEGDTAPLHGYTLHYKPEFGE---WETSE 1457
            .| .|...|..|                ::.|..:|.......:.||.:.|:.:..:   :.|.|
Zfish  1445 LP-PTAERTKDDVPGPPVRLMFPEVRLSSVRVVWQPPSEPNGIIMGYQISYRLDINDPNKFTTVE 1508

  Fly  1458 VSVDSQKHNIEGLLCGSRY--QVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSV 1520
            |..::::..:.||:..|.|  |:.|......|..:.:.::.|    :|.:.|:.||.:.|....|
Zfish  1509 VGSNARQFTVTGLMPESAYVFQITARTLQGWGPADEAIVITT----EKRERPQAPRRLTVPQKGV 1569

  Fly  1521 S-----LHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNN--YVVLDLEPATWYNLRIT 1578
            .     ||:.|..||..|:.:|.:::.:....:|...:::: |.||  :.|..|:|.|.|..|:.
Zfish  1570 ESYKLRLHWMAGGDGSSPVRYFTLQTLELPDGDWKTHTSSI-PHNNSSWEVDRLKPYTSYKFRMM 1633

  Fly  1579 AHNSAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTRIR-------LPAWMPEWLDLNFMVPL 1636
            |.|..|.:....:...:|.       |.|..|...|...::       :..|.|         |.
Zfish  1634 ATNDVGDSAFSKETEPVTT-------LQDVPGEAPVILLVKPSTTTSVIVQWQP---------PA 1682

  Fly  1637 IATVVVVAVG 1646
            ..||..:.||
Zfish  1683 EGTVNGILVG 1692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653	24/73 (33%)
		IGc2	361..413	CDD:197706	20/53 (38%)
		I-set	433..527	CDD:254352	30/127 (24%)
		IGc2	446..517	CDD:197706	24/96 (25%)
		I-set	533..618	CDD:254352	20/95 (21%)
		IGc2	544..607	CDD:197706	15/72 (21%)
		Ig	641..714	CDD:143165	16/76 (21%)
		IGc2	735..804	CDD:197706	20/76 (26%)
		I-set	819..914	CDD:254352	23/96 (24%)
		Ig	833..921	CDD:299845	23/89 (26%)
		FN3	918..1011	CDD:238020	38/97 (39%)
		FN3	1018..1116	CDD:238020	26/98 (27%)
		FN3	1124..1217	CDD:238020	30/104 (29%)
		FN3	1222..1312	CDD:238020	26/90 (29%)
		Ig	1339..1406	CDD:299845	28/257 (11%)
		FN3	1409..1499	CDD:238020	22/110 (20%)
		FN3	1504..1584	CDD:238020	24/86 (28%)
		Dscam_C	1890..2008	CDD:289151
sdk1b	XP_017211454.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910