DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and lrit1a

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_001018174.2	Gene:	lrit1a / 553943	ZFINID:	ZDB-GENE-040924-5	Length:	643	Species:	Danio rerio

Alignment Length:	564	Identity:	111/564 - (19%)
Similarity:	191/564 - (33%)	Gaps:	171/564 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1276 YQMSFEATELEKNK----PYEF---WVTASTTIGEGQQSKSIVAMPSD---------------QV 1318
            |..:....:|..|.    |.|.   |:|...|:| .:.||.|:.:..:               :.
Zfish   153 YMKNITYLDLSSNNLLTVPAEVLNTWLTIKPTLG-AESSKLILGLHDNPWLCDCRLYDLVQFQKS 216

  Fly  1319 PAKIASFDDT---------FTATFKEDAK-------------------------MPCLAVGAPQP 1349
            |:...:|.||         .:.....||:                         :.|..||.|.|
Zfish   217 PSLSVAFIDTRLRCADPESLSGVLFSDAELRRCQGPRVHTAVARVRSAVGNNVLLRCGTVGVPIP 281

  Fly  1350 EITWK------IKGVEFSANDRMRVLPDGSLL-IKSVNRQDAGDYSCHAENSIAKDSITHKLIVL 1407
            |:.|:      :.|.....|.:..::  .|:| :.:|:.:|.|.|.|.|.|..........||:.
Zfish   282 ELAWRRADGKPLNGTVLLENSKEGIV--WSILSVPAVSYRDTGKYICKATNYAGSAEAVISLIIN 344

  Fly  1408 APPQSPHVTL----------------SATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGEWETS 1456
            ..|:..:.||                :|.....:...:.|...:..||.| |:.|...:...|:.
Zfish   345 DAPKMENPTLDPKPKLKSKKPNTMVKAAYQEKHIATYVSPTPKNGLPLSG-TVSYTGPYPGMESD 408

  Fly  1457 EVS---VDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKP-KLPEKPRFIEVSS 1517
            ..:   :::|..:.:|.|        .|..:|:.|       ||.:..|.| ::....:.|..:.
Zfish   409 NAANSRMNTQTASPDGFL--------ETNLSNLAA-------NTSSLQQDPDRVVRSVKVIGDTD 458

  Fly  1518 NSVSLHFKAWKDGGCPMSH----FVVESKKRDQIEWNQISNNVKPDNNYVVLD-LEPATWYNLRI 1577
            .:|.|:::|      |.:.    |.|......:.:..:|  ||.|.||.:|:: |.|.|.|
Zfish   459 YTVCLNWRA------PTAKNTTAFSVLYAVFGERDMRRI--NVSPGNNRIVIEGLVPKTKY---- 511

  Fly  1578 TAHNSAGFTVAEYDFATLTVTGGTIAP--------LDDGSGHGNVHTRIRLPAWMPEWLDLNFMV 1634
                          .|.:.|.|  :.|        ..|.:...|...::           :|.:|
Zfish   512 --------------IACVCVKG--LIPKKEQCVIFSTDAAASANGTQKL-----------INVVV 549

  Fly  1635 PLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVYNQTMGPGATLDKRRPDLRDELGYI 1699
            ..:|.|:.|.:.:.|.|.||.|:....:....||:....|..:|:.|..    :...|..|  |:
Zfish   550 ITVACVIAVPLTVIVCCGALKRKIKKFLGKNSKDIQDSYVTFETLSPST----KAKGLEGE--YL 608

  Fly  1700 APPNRKLPPVPGSNYNTCDRIKRGRGGLRSNHSTWDPRRNPNLY 1743
            ...|.:          ..:|:...|..|.| .||......||.|
Zfish   609 TRLNAE----------ESNRLLSARSSLDS-ESTAKIEGQPNEY 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352
		IGc2	544..607	CDD:197706
		Ig	641..714	CDD:143165
		IGc2	735..804	CDD:197706
		I-set	819..914	CDD:254352
		Ig	833..921	CDD:299845
		FN3	918..1011	CDD:238020
		FN3	1018..1116	CDD:238020
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020	12/42 (29%)
		Ig	1339..1406	CDD:299845	19/73 (26%)
		FN3	1409..1499	CDD:238020	19/108 (18%)
		FN3	1504..1584	CDD:238020	19/85 (22%)
		Dscam_C	1890..2008	CDD:289151
lrit1a	NP_001018174.2	leucine-rich repeat	61..84	CDD:275378
		LRR_8	63..119	CDD:290566
		LRR_RI	<77..175	CDD:238064	5/21 (24%)
		leucine-rich repeat	85..108	CDD:275378
		LRR_8	108..167	CDD:290566	3/13 (23%)
		leucine-rich repeat	109..132	CDD:275378
		leucine-rich repeat	133..156	CDD:275378	1/2 (50%)
		leucine-rich repeat	157..170	CDD:275378	2/12 (17%)
		LRRCT	199..243	CDD:214507	4/43 (9%)
		I-set	252..343	CDD:254352	19/92 (21%)
		Ig	259..333	CDD:299845	18/75 (24%)
		fn3	448..515	CDD:278470	19/92 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900