DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and KIRREL1

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	920	Identity:	195/920 - (21%)
Similarity:	307/920 - (33%)	Gaps:	272/920 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 DPPTQTVDFGRPAVFTC---QYTGNPIKTVSWMKDGKAIGHSE-----PVLRIESVKKEDKGMYQ 408
            :|..|||..|:.||..|   .|:|    .|.|.|||.|:|..:     |..|:  |...|.|.|.
Human    26 EPADQTVVAGQRAVLPCVLLNYSG----IVQWTKDGLALGMGQGLKAWPRYRV--VGSADAGQYN 84

  Fly   409 CFVRNDQESAEAS-----AELKLGGR------FDPPVIRQAFQEETMEPGPSVFLK--------C 454
            ..:.:.:.|.:||     .|..|..|      ..||      ::..::.||.:.|:        |
Human    85 LEITDAELSDDASYECQATEAALRSRRAKLTVLIPP------EDTRIDGGPVILLQAGTPHNLTC 143

  Fly   455 VA-GGNPTPEISWELDGKK----IANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKS 514
            .| ...|...|.|..||.:    :|:.:..:.|:..|    .||.|.|.....:.|.::.|.:.:
Human   144 RAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET----TVSQLLINPTDLDIGRVFTCRSMN 204

  Fly   515 KV--GVAEHSAKLNVYGLPYIR-QMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQ 576
            :.  ...|.|.:|:|:..|.:. .:|.:.:..||.::.||
Human   205 EAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTC------------------------- 244

  Fly   577 KVFPNGTLIIENVERNSDQATYTCVAKNQE--GYS-ARGSLEVQVMVLPQIVPFAYEDLINMGDS 638
                              |||     .|.|  ||. |:|.             |..||
Human   245 ------------------QAT-----ANPEILGYRWAKGG-------------FLIED------- 266

  Fly   639 IDLFCQIQKGDRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKTSMISIPSASPAHTGRDTCIA 703
                           .|.|...:..||.|           .:|..|                |..
Human   267 ---------------AHESRYETNVDYSF-----------FTEPVS----------------CEV 289

  Fly   704 SNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGD----TPG 764
            .||.|:|..|..:.|:..||.:::|.......|||..:.|...|.|...:||.|...:    .||
Human   290 HNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPG 354

  Fly   765 EYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQT 829
            ...:...|..:......|.:.::.:.:.|.|.|.||..........:.:.|..||..:.: ..|.
Human   355 SPPEAALSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSE-AVQY 418

  Fly   830 ARRGEPAVLQC-EAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSD-S 892
            |.||:...::| ......|..|.|......|:.....|||:......:||:|:|:|.....:| .
Human   419 AVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQ 483

  Fly   893 ALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIE--- 954
            ..:.|.|.|:||...|.|.:..:||  :|..:......|.|:.|.:            :.|.
Human   484 THYNCTAWNSFGPGTAIIQLEEREV--LPVGIIAGATIGASILLIF------------FFIALVF 534

  Fly   955 --FKRSRASWSE------------IDRVIVPGHT-TEAQVQKLSPATTYNIRIVA--ENAIGTSQ 1002
              ::|.:.|..:            ::|..:..|: .|.....:|.||.....|.:  ::.:...|
Human   535 FLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQ 599

  Fly  1003 SSEAVTIITAEE----APSGKPQNIKV---EPVNQTTMRVTWKPPPRTEWNG---EILGYYVGYK 1057
            .....||.|.||    .|:....|::.   .|.::..:...::.|....::|   ..|.:..||.
Human   600 DLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYA 664

  Fly  1058 LSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPS 1122
            ..||.|                                         .||.|:    :..|.||.
Human   665 QLNTYS-----------------------------------------RGPASD----YGPEPTPP 684

  Fly  1123 QP--PSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVY--APSD-------EWYDETKRHYK 1176
            .|  |:.|..|:..|......:.|.|...|.| ..||::.|  ||..       |.||...::..
Human   685 GPAAPAGTDTTSQLSYENYEKFNSHPFPGAAG-YPTYRLGYPQAPPSGLERTPYEAYDPIGKYAT 748

  Fly  1177 KTASSDTVLH 1186
            .|..|.|..|
Human   749 ATRFSYTSQH 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653	27/84 (32%)
		IGc2	361..413	CDD:197706	19/59 (32%)
		I-set	433..527	CDD:254352	23/108 (21%)
		IGc2	446..517	CDD:197706	19/85 (22%)
		I-set	533..618	CDD:254352	14/88 (16%)
		IGc2	544..607	CDD:197706	9/64 (14%)
		Ig	641..714	CDD:143165	12/72 (17%)
		IGc2	735..804	CDD:197706	18/72 (25%)
		I-set	819..914	CDD:254352	26/96 (27%)
		Ig	833..921	CDD:299845	24/89 (27%)
		FN3	918..1011	CDD:238020	17/112 (15%)
		FN3	1018..1116	CDD:238020	13/103 (13%)
		FN3	1124..1217	CDD:238020	21/74 (28%)
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352	29/95 (31%)
		Ig	25..116	CDD:299845	29/95 (31%)
		Ig2_KIRREL3-like	138..219	CDD:143236	19/84 (23%)
		I-set	223..304	CDD:254352	31/190 (16%)
		Ig_2	227..305	CDD:290606	30/187 (16%)
		Ig_2	311..405	CDD:290606	19/93 (20%)
		IG_like	314..405	CDD:214653	19/90 (21%)
		Ig5_KIRREL3	407..504	CDD:143306	27/97 (28%)
		IG_like	416..504	CDD:214653	25/87 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10991
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900