DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam1 and SDK2

DIOPT Version :9

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens


Alignment Length:2347 Identity:480/2347 - (20%)
Similarity:810/2347 - (34%) Gaps:691/2347 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 W-LMLFAAVALIACGSQTLAANPPDADQKGPVFLKEPTNRIDFSNSTGAEIECKASGNPMPEIIW 73
            | |:::..:||    .|..||..  .|...|.|..||.............:.|.|.|:...|..|
Human     2 WGLLIWTLLAL----HQIRAARA--QDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKW 60

  Fly    74 IRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYR------QEVHAQVYACLARNQFGSIISRDVH 132
            :.::          |:::.        |..| ||      ...||..|.|:.||:.|:::.|...
Human    61 LHNN----------RELTK--------FSLE-YRYMITSLDRTHAGFYRCIVRNRMGALLQRQTE 106

  Fly   133 VRAVVSQHYEEDIHKAFVIRGNSAILKCD-IPSFVADFVNVISWHSDEKENFYPGTEYDGKYLVL 196
            |:......:||......|..|.:|:::.. |.||...   .::|..|.::             :.
Human   107 VQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQP---QVTWFRDGRK-------------IP 155

  Fly   197 PSGELHI---------REVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPVGSVSPQLSGN 252
            ||..:.|         ..|.|:.|  .|..:..:...|:.:.|         :|:......:.|.
Human   156 PSSRIAITLENTLVILSTVAPDAG--RYYVQAVNDKNGDNKTS---------QPITLTVENVGGP 209

  Fly   253 GNQEHITLTRVPKMGS-------VTLMCPAQAYPVPFFR--WYKFIEGTTRKQAVVLNDRVKQVS 308
            .:....|:...||..|       |||.|.|.|.|:....  |        :|..|:|:..:...:
Human   210 ADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIW--------KKDGVLLSGGISDHN 266

  Fly   309 GTLIIKDAVVEDSGKYLC--VVNNSVGGESVETV-----LTVTAPLSAKIDPPTQ-TVDFGRPAV 365
            ..|.|.:....|:|.|.|  |:.:|    ||.:|     |:|..|.....:|... |.:..:...
Human   267 RRLTIPNPTGSDAGYYECEAVLRSS----SVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVD 327

  Fly   366 FTCQYTGNPIKTVSWMKDGKAI---------GHSEPVLRIESVKKEDKGMYQCFVRNDQESAEAS 421
            ..||..|.|..:::|.||...:         ..::..|:|..:..:|.||:|||.||.....:.|
Human   328 IPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTS 392

  Fly   422 AELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVT 486
            ..|.:..  ..|.|.:...:.|:..|.||.|.|...|.|.|.|:|: .|::|..:...|:.::..
Human   393 TYLAVTS--IAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQ-KGERILASGSVQLPRFTP 454

  Fly   487 VNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYI-RQMEKKAIVAGETLIVT 550
            :..   ..|.|:..|.:|.|.|.|:|.:..||.|.||.|.|:....| :..:.::::.|....:.
Human   455 LES---GSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMV 516

  Fly   551 CPVAGYPIDSI--VWERDNRALPINRKQKV--FPNGTLIIENVERNSDQATYTCVAKNQEGYSAR 611
            |.|...|..:|  :||:|...|......::  ..||:|.|... .:.|..||||...:..|..:|
Human   517 CGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQT-WSGDIGTYTCRVISAGGNDSR 580

  Fly   612 GSLEVQVMVLPQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERSAGDYGFDQVQP---- 672
             |..::|..||.    |.|..:....:::        .|.|.:.|:       ..||...|    
Human   581 -SAHLRVRQLPH----APEHPVATLSTVE--------RRAINLTWT-------KPFDGNSPLIRY 625

  Fly   673 --QMRTNR---------ISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDL-TVNVPPRWI 725
              :|..|.         :..|.:.:::....||.:.:....|.|..|...:|.|. .|::|....
Human   626 ILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPP 690

  Fly   726 LEPTDKAFAQGS---------DAKVECKADGFPKPQVTWKKAVGDTPG-EYKDLKKSD--NIRVE 778
            ..|.....|.|.         ....|...:|..|..:......|...| ::|::..:|  |:.:|
Human   691 TAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLE 755

  Fly   779 E---------------------------------------GTLHVDNIQKTNEGYY----LCEAI 800
            :                                       |.:|.:....|...:.    ..:.|
Human   756 DLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFI 820

  Fly   801 NGIGSGLSAVIMISVQAPPEFTEKLRNQTAR---------------------------------- 831
            |||..|...:..     .||..|::...|||                                  
Human   821 NGINQGYKLIAW-----EPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDG 880

  Fly   832 -RGEPAVLQCEAKGEKPIG-------------ILWN--------MNNMRLDPKNDNRYTIREEIL 874
             |..|.:::.......|:|             :.|.        :...|:..:..||...|    
Human   881 PRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTR---- 941

  Fly   875 STGVMSSLSIKRTERSDSALFT----CVATNAFGSDDASINMIVQ----EVPEMPYALKVLDKSG 931
            .|..:.:::::......:||.|    ..|..:.|....|.:.|..    |:|..|..|.:.:...
Human   942 VTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGP 1006

  Fly   932 RSVQLSWAQPYDGNSPLDRYIIEFK----RSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRI 992
            |||.|.:...|||.:.:.|:::|.:    .....|..|.::.........:|..|:|.|.|:.|:
Human  1007 RSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRM 1071

  Fly   993 VAENAIGTSQSSE-AVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNG--EILGYYV 1054
            ...|.:|||..|: :..|.|.:..|...|.|:.:...::|::.:.|.|.|..|:||  |.:||.:
Human  1072 RQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKI 1136

  Fly  1055 GYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEG 1119
            .|..|:.:.    :|::.:.::..|.:..:::|..:|:|.|.:||||.||:||.|:.....|.|.
Human  1137 KYSRSDGHG----KTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRES 1197

  Fly  1120 TPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHY--KKTASSD 1182
            .||..|::.:....||.::.|.|...|....||::..|||:|...|.  |...|.:  :..:|..
Human  1198 VPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDS--DTQPRFWLVEGNSSRS 1260

  Fly  1183 TVLHGLKKYTNYTMQVLATTAGGDGVRS-VPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPA 1246
            ..|.||.||..|.:||||.|..|||..| .||..:|..|||..|..:....:...::.:.|:|||
Human  1261 AQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPA 1325

  Fly  1247 QPNGIITQYTVYSKAEGAETETKTQKV--PHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKS 1309
            .|||||..|.:..:.......|.|.:|  |..: .:.||.|:....|.|.:||.|..|.|:.:::
Human  1326 APNGIILAYQITHRLNTTTANTATVEVLAPSAR-QYTATGLKPESVYLFRITAQTRKGWGEAAEA 1389

  Fly  1310 IVAMPS----DQVPAKIASFDDTFTATFKEDAKMPCLAVG--------AP----------QPEIT 1352
            :|....    .|.|::        ....:||.:...:.:.        :|          .|...
Human  1390 LVVTTEKRDRPQPPSR--------PMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGR 1446

  Fly  1353 WKIKGVEFSAN------DRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQ 1411
            |.:.....|.|      ||::........:|:.|  |.||    :|.|...:|:|  .:..||.:
Human  1447 WALHSASVSHNASSFIVDRLKPFTSYKFRVKATN--DIGD----SEFSEESESLT--TLQAAPDE 1503

  Fly  1412 SPHVTLSAT--TTDALTVKLKP---------------------HEGDTAPLHGYTLH-------- 1445
            :|.: ||.|  ||.::.::.:|                     :||    |.|:||.        
Human  1504 APTI-LSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEG----LRGFTLRGINNPGAT 1563

  Fly  1446 -------------YKPEFGEWETSEVS-------------------------------------- 1459
                         .:|...::|...::                                      
Human  1564 WAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPR 1628

  Fly  1460 --------------------VDSQKHNIEGL------------------------------LCG- 1473
                                :|||..:|:|.                              |.| 
Human  1629 NVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGY 1693

  Fly  1474 SRYQVYATGFNNIGAGEASDILNTRTKGQKPKLP-----------------EKPRF--------- 1512
            :.|.|....||..|.|..|.....:|:...|..|                 |.|:|         
Human  1694 TAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYR 1758

  Fly  1513 -----------------IEVSSNS----------------------------------------- 1519
                             ::|..||                                         
Human  1759 LVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEG 1823

  Fly  1520 ----------------VSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNV-KPDNNYVV-LD 1566
                            :::|:.:...|..|::.:|:|::..|:..|:.:..:: |..::|.. :|
Human  1824 APGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMD 1888

  Fly  1567 -LEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRLPA-----WMP 1625
             |:|...|:.|:.|.|..||             |...:|...            :||     :..
Human  1889 ILKPGVSYDFRVIAVNDYGF-------------GTPSSPSQS------------VPAQKANPFYE 1928

  Fly  1626 EWLDLNFMVPLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVYNQTMG------PGAT 1684
            ||..| .::.|:..:.::.:...::....|::.|.....|.......:.:::.|.      |...
Human  1929 EWWFL-VVIALVGLIFILLLVFVLIIRGQSKKYAKKTDSGNSAKSGALGHSEMMSLDESSFPALE 1992

  Fly  1685 LDKRRPDLRDELG-----YIAPPNRKLPPVPGS---------NYNTCDRIKRGRGGLRSNHS-TW 1734
            |:.||..:::...     |...|.|   |.|||         .||  |.|......|....| ..
Human  1993 LNNRRLSVKNSFCRKNGLYTRSPPR---PSPGSLHYSDEDVTKYN--DLIPAESSSLTEKPSEIS 2052

  Fly  1735 DPRRNPNLYEELKAPPVPMHGNHY-GHAHGNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKA 1798
            |.:.:.:.||        :..||. .|:..|   ||                      ..|||  
Human  2053 DSQGSDSEYE--------VDSNHQKAHSFVN---HY----------------------ISDPT-- 2082

  Fly  1799 MNFQTFPHQNGHAGPVPGHAGTMLPPGHPGH------VHSRSGSQSMPRANR----YQRKNSQGG 1853
             .:.::..|.........::.|....|.|.|      ..::.||...|:|:|    ....|....
Human  2083 -YYNSWRRQQKGISRAQAYSYTESDSGEPDHTTVTNSTSTQQGSLFRPKASRTPTPQNPPNPPSQ 2146

  Fly  1854 QSSIYTP 1860
            ||::|.|
Human  2147 QSTLYRP 2153

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 Ig 38..130 CDD:299845 21/97 (22%)
IG 57..133 CDD:214652 18/81 (22%)
IG_like 267..343 CDD:214653 24/91 (26%)
Ig 269..340 CDD:143165 21/74 (28%)
IG_like 353..425 CDD:214653 20/81 (25%)
IGc2 361..413 CDD:197706 15/60 (25%)
I-set 433..527 CDD:254352 30/93 (32%)
IGc2 446..517 CDD:197706 21/70 (30%)
I-set 533..618 CDD:254352 22/89 (25%)
IGc2 544..607 CDD:197706 18/66 (27%)
Ig 641..714 CDD:143165 14/87 (16%)
IGc2 735..804 CDD:197706 16/123 (13%)
I-set 819..914 CDD:254352 22/154 (14%)
Ig 833..921 CDD:299845 18/116 (16%)
FN3 918..1011 CDD:238020 26/97 (27%)
FN3 1018..1116 CDD:238020 29/99 (29%)
FN3 1124..1217 CDD:238020 33/95 (35%)
FN3 1222..1312 CDD:238020 26/91 (29%)
Ig 1339..1406 CDD:299845 16/90 (18%)
FN3 1409..1499 CDD:238020 30/222 (14%)
FN3 1504..1584 CDD:238020 24/182 (13%)
Dscam_C 1890..2008 CDD:289151
SDK2NP_001138424.1 Ig 27..109 CDD:299845 22/100 (22%)
IG_like 40..109 CDD:214653 19/87 (22%)
I-set 120..203 CDD:254352 18/109 (17%)
Ig 132..210 CDD:299845 16/104 (15%)
IG_like 222..304 CDD:214653 25/93 (27%)
IGc2 233..286 CDD:197706 17/60 (28%)
I-set 308..397 CDD:254352 21/88 (24%)
Ig 326..394 CDD:143165 18/67 (27%)
I-set 402..492 CDD:254352 30/93 (32%)
Ig 416..492 CDD:299845 27/79 (34%)
Ig 502..586 CDD:299845 21/85 (25%)
IG_like 502..586 CDD:214653 21/85 (25%)
FN3 590..681 CDD:238020 19/109 (17%)
FN3 693..786 CDD:238020 12/92 (13%)
FN3 794..890 CDD:238020 16/100 (16%)
FN3 895..983 CDD:238020 14/91 (15%)
FN3 993..1087 CDD:238020 25/93 (27%)
FN3 1099..1194 CDD:238020 29/98 (30%)
FN3 1201..1290 CDD:238020 31/90 (34%)
FN3 1301..1394 CDD:238020 27/93 (29%)
FN3 1400..1484 CDD:238020 14/93 (15%)
FN3 1503..1616 CDD:238020 15/117 (13%)
FN3 1626..1719 CDD:238020 14/92 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729 6/21 (29%)
FN3 1724..1805 CDD:238020 8/80 (10%)
FN3 1837..1916 CDD:238020 20/91 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067 5/35 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172 14/56 (25%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.