DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam1 and Il27ra

DIOPT Version :9

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:NP_057880.2 Gene:Il27ra / 50931 MGIID:1355318 Length:623 Species:Mus musculus


Alignment Length:592 Identity:120/592 - (20%)
Similarity:190/592 - (32%) Gaps:172/592 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   829 TARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKND----------------NRYTIREEILSTG 877
            |...|.|..|||.:.|  |:|||    |...:|..|                ||..   |:....
Mouse    25 TRPHGSPGPLQCYSVG--PLGIL----NCSWEPLGDLETPPVLYHQSQKYHPNRVW---EVKVPS 80

  Fly   878 VMSSLSIKRTE--RSDSALFTCVATNAFGS-------DDASINMIVQEVPEMPYALKVLDKSGRS 933
            ..|.::|.|.:  .:|..|.       :|:       ...|:|:..|..|:.|.....:|.|..:
Mouse    81 KQSWVTIPREQFTMADKLLI-------WGTQKGRPLWSSVSVNLETQMKPDTPQIFSQVDISEEA 138

  Fly   934 ---VQLSWAQPYDGNSPLDRYII---EFKRSRA-SWSEIDRVIVPGHTTEAQVQKLSPATTYNI- 990
               ..:.||.|.   .|..:.:|   .:|..:| :|:.::..:.....|..::|.|.|.|.|.: 
Mouse   139 TLEATVQWAPPV---WPPQKVLICQFRYKECQAETWTRLEPQLKTDGLTPVEMQNLEPGTCYQVS 200

  Fly   991 -RIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKV-----EPVNQTTMRVTWKPP------PRT 1043
             |...||.....:.|..::.    :.|...|:::.|     |...:....:.||.|      ..|
Mouse   201 GRCQVENGYPWGEWSSPLSF----QTPFLDPEDVWVSGTVCETSGKRAALLVWKDPRPCVQVTYT 261

  Fly  1044 EWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPL 1108
            .|.|                      ...||...:|.......:..:.:::||... |.....|.
Mouse   262 VWFG----------------------AGDITTTQEEVPCCKSPVPAWMEWAVVSPG-NSTSWVPP 303

  Fly  1109 SEEEKQFTAEGTPSQPPSDTACTTLT-SQTIRVGW---VSPPLESANGVIKTYKVVYAPSDEWYD 1169
            :.......|   |...|.|...::.. |..|:|.|   ...|||        |.|.:|...:..|
Mouse   304 TNLSLVCLA---PESAPCDVGVSSADGSPGIKVTWKQGTRKPLE--------YVVDWAQDGDSLD 357

  Fly  1170 ETKRHYKKTASSDTVLHG-LKKYTNYTMQVLATTAGG-------DGVRS--VPIHCQTEPDVPEA 1224
            :.........:..|:|.| .|....|.:.|.|..:||       .|.|.  ||:.......:|:.
Mouse   358 KLNWTRLPPGNLSTLLPGEFKGGVPYRITVTAVYSGGLAAAPSVWGFREELVPLAGPAVWRLPDD 422

  Fly  1225 PTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAET-------ETKTQKVPHYQMSFEA 1282
            |.....:..|..       |..|..|..|.||...::.|..|       :|:|..:|:..:.   
Mouse   423 PPGTPVVAWGEV-------PRHQLRGQATHYTFCIQSRGLSTVCRNVSSQTQTATLPNLHLG--- 477

  Fly  1283 TELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAP 1347
                   .::.|||.||..|:|...                                |.|::..|
Mouse   478 -------SFKLWVTVSTVAGQGPPG--------------------------------PNLSLHLP 503

  Fly  1348 QPEITWK 1354
            ...|.||
Mouse   504 DNRIRWK 510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 Ig 38..130 CDD:299845
IG 57..133 CDD:214652
IG_like 267..343 CDD:214653
Ig 269..340 CDD:143165
IG_like 353..425 CDD:214653
IGc2 361..413 CDD:197706
I-set 433..527 CDD:254352
IGc2 446..517 CDD:197706
I-set 533..618 CDD:254352
IGc2 544..607 CDD:197706
Ig 641..714 CDD:143165
IGc2 735..804 CDD:197706
I-set 819..914 CDD:254352 25/109 (23%)
Ig 833..921 CDD:299845 26/112 (23%)
FN3 918..1011 CDD:238020 22/101 (22%)
FN3 1018..1116 CDD:238020 16/108 (15%)
FN3 1124..1217 CDD:238020 26/106 (25%)
FN3 1222..1312 CDD:238020 21/96 (22%)
Ig 1339..1406 CDD:299845 6/16 (38%)
FN3 1409..1499 CDD:238020
FN3 1504..1584 CDD:238020
Dscam_C 1890..2008 CDD:289151
Il27raNP_057880.2 FN3 123..222 CDD:238020 22/105 (21%)
WSXWS motif 211..215 0/3 (0%)
Box 1 motif 552..560
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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