DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam1 and NTM

DIOPT Version :9

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:NP_001338930.1 Gene:NTM / 50863 HGNCID:17941 Length:367 Species:Homo sapiens


Alignment Length:329 Identity:83/329 - (25%)
Similarity:132/329 - (40%) Gaps:44/329 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   626 PFAYEDL-INMGDSIDLFCQIQKGDRPIKVHWSFERSAGDY-GFDQ--VQPQMRTNRISEKTSMI 686
            |.|.::: :..|:|..|.|.|.  :|..:|.| ..||...| |.|:  :.|::.....::....|
Human    39 PKAMDNVTVRQGESATLRCTID--NRVTRVAW-LNRSTILYAGNDKWCLDPRVVLLSNTQTQYSI 100

  Fly   687 SIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKP 751
            .|.:......|..||.........|..|.|.|.|.|:.:...:|.:..:|::..:.|.|.|.|:|
Human   101 EIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEP 165

  Fly   752 QVTWK----KAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIM 812
            .|||:    ||||...              |:..|.:..|.:...|.|.|.|.|.:.:.:...:.
Human   166 TVTWRHISPKAVGFVS--------------EDEYLEIQGITREQSGDYECSASNDVAAPVVRRVK 216

  Fly   813 ISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRL-----DPKNDNRYTIREE 872
            ::|..||..:| .:......|:...|||||.........|..::.||     ..|.:||      
Human   217 VTVNYPPYISE-AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENR------ 274

  Fly   873 ILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLS 937
                ..:|.|........|...:||||:|..|..:|||.:.  |:.| |.:..:|.:...:....
Human   275 ----PFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF--ELNE-PTSSTLLQEVKTTALTP 332

  Fly   938 WAQP 941
            |..|
Human   333 WKGP 336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 Ig 38..130 CDD:299845
IG 57..133 CDD:214652
IG_like 267..343 CDD:214653
Ig 269..340 CDD:143165
IG_like 353..425 CDD:214653
IGc2 361..413 CDD:197706
I-set 433..527 CDD:254352
IGc2 446..517 CDD:197706
I-set 533..618 CDD:254352
IGc2 544..607 CDD:197706
Ig 641..714 CDD:143165 18/75 (24%)
IGc2 735..804 CDD:197706 21/72 (29%)
I-set 819..914 CDD:254352 26/99 (26%)
Ig 833..921 CDD:299845 26/92 (28%)
FN3 918..1011 CDD:238020 5/24 (21%)
FN3 1018..1116 CDD:238020
FN3 1124..1217 CDD:238020
FN3 1222..1312 CDD:238020
Ig 1339..1406 CDD:299845
FN3 1409..1499 CDD:238020
FN3 1504..1584 CDD:238020
Dscam_C 1890..2008 CDD:289151
NTMNP_001338930.1 Ig 44..132 CDD:416386 22/90 (24%)
Ig strand A' 44..49 CDD:409353 0/4 (0%)
Ig strand B 51..59 CDD:409353 3/7 (43%)
CDR1 59..63 CDD:409353 1/5 (20%)
FR2 64..70 CDD:409353 2/6 (33%)
Ig strand C 64..70 CDD:409353 2/6 (33%)
CDR2 71..83 CDD:409353 5/11 (45%)
Ig strand C' 72..76 CDD:409353 1/3 (33%)
Ig strand C' 80..83 CDD:409353 1/2 (50%)
FR3 84..118 CDD:409353 6/33 (18%)
Ig strand D 87..94 CDD:409353 0/6 (0%)
Ig strand E 97..103 CDD:409353 1/5 (20%)
Ig strand F 110..118 CDD:409353 3/7 (43%)
CDR3 119..123 CDD:409353 0/3 (0%)
Ig strand G 123..132 CDD:409353 3/8 (38%)
FR4 125..132 CDD:409353 3/6 (50%)
Ig_3 136..205 CDD:404760 22/82 (27%)
Ig strand A' 142..147 CDD:409353 1/4 (25%)
Ig strand B 153..160 CDD:409353 1/6 (17%)
Ig strand C 166..171 CDD:409353 3/4 (75%)
Ig strand D 177..180 CDD:409353 2/2 (100%)
Ig strand E 184..190 CDD:409353 1/5 (20%)
Ig strand F 197..204 CDD:409353 3/6 (50%)
Ig strand G 211..219 CDD:409353 0/7 (0%)
Ig_3 222..299 CDD:404760 22/87 (25%)
putative Ig strand A 223..229 CDD:409353 2/6 (33%)
Ig strand B 239..243 CDD:409353 1/3 (33%)
Ig strand C 252..256 CDD:409353 0/3 (0%)
Ig strand E 278..282 CDD:409353 2/3 (67%)
Ig strand F 292..297 CDD:409353 2/4 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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