back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and L1cam

DIOPT Version :10

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_059041.2	Gene:	L1cam / 50687	RGDID:	619777	Length:	1255	Species:	Rattus norvegicus

Alignment Length:	1347	Identity:	321/1347 - (23%)
Similarity:	527/1347 - (39%)	Gaps:	254/1347 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 IDPPTQTVDFGRPAV--------FTCQYTGNPIKTVSWMKDG------KAIG---HSEPV---LR 395
            ::||..|....|..|        ..|:..|.|.....|.|||      :.:|   |..|.   ..
  Rat    32 LEPPVITEQSPRRLVVFPTDDISLKCEARGRPQVEFRWTKDGIHFKPKEELGVVVHEAPYSGSFT 96

  Fly   396 IE---SVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAG 457
            ||   |..:..:|:|:|:..|:..:| .|.|::|.....|...::..:...:|.|.||.|.|
  Rat    97 IEGNNSFAQRFQGIYRCYASNNLGTA-MSHEIQLVAEGAPKWPKETVKPVEVEEGESVVLPC--- 157

  Fly   458 GNPTP-----EISWELDGK--KIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAK-- 513
             ||.|     .|.| ::.|  .|..::|..:||    |||:.....:||.:.:|   |.|.|.
  Rat   158 -NPPPSAAPLRIYW-MNSKILHIKQDERVSMGQ----NGDLYFANVLTSDNHSD---YICNAHFP 213

  Fly   514 -SKVGVAEHSAKLNVYGLPYIRQMEKKA-----------IVA--GETLIVTCPVAGYPIDSIVWE 564
             ::..:.:....|.|  .|....:::|.           :||  |::||:.|...|:|..:|.|.
  Rat   214 GTRTIIQKEPIDLRV--KPTNSMIDRKPRLLFPTNSSSHLVALQGQSLILECIAEGFPTPTIKWL 276

  Fly   565 RDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVLPQIVPFAY 629
            ..:..:|.:|......|.||.:.|| ...|...|||:|:|..| |||.:..|.|...|..:....
  Rat   277 HPSDPMPTDRVIYQNHNKTLQLLNV-GEEDDGEYTCLAENSLG-SARHAYYVTVEAAPYWLQKPQ 339

  Fly   630 EDLINMGDSIDLFCQIQKGDRPIKVHW-----SFERSAGDYGFDQVQPQMRTNRISEKTSMISIP 689
            ..|...|::..|.||:|...:| :|.|     |.|:...|..:          ||.:.:.::|
  Rat   340 SHLYGPGETARLDCQVQGRPQP-EVTWRINGMSIEKVNKDQKY----------RIEQGSLILS-- 391

  Fly   690 SASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAF--AQGSDAKVECKADGFPKPQ 752
            :..|:.|....|.|.|:.|....:..:.|...|..||...::.:  .:||.|.:.|||.|.|.|.
  Rat   392 NVQPSDTMVTQCEARNQHGLLLANAYIYVVQLPARILTKDNQTYMAVEGSTAYLLCKAFGAPVPS 456

  Fly   753 VTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQA 817
            |.|....|.|.     |:.........|||.:.::|..:.|.|.|:|.|. .:.::.:..:.|:.
  Rat   457 VQWLDEEGTTV-----LQDERFFPYANGTLGIRDLQANDTGRYFCQAAND-QNNVTILANLQVKE 515

  Fly   818 PPEFTEKLRNQTARRGEPAVLQCEAKGEKPI--GILWNMNNMRLDPKND-NRYTIREEILSTGVM 879
            ..:.|:..|:...::|......|:|..:..:  .|.|..:...|..:.| ::|.|.:
  Rat   516 ATQITQGPRSTIEKKGARVTFTCQASFDPSLQASITWRGDGRDLQERGDSDKYFIED-------- 572

  Fly   880 SSLSIKRTERSDSALFTCVATNAFGSDDASINMIV----QEVPEMPYALKVLDKSGRSVQLSWAQ 940
            ..|.|:..:.||...::|||:......::...::|    ..||.:..:.:.|.|..: |.|||:.
  Rat   573 GQLVIQSLDYSDQGNYSCVASTELDEVESRAQLLVVGSPGPVPHLELSDRHLLKQSQ-VHLSWSP 636

  Fly   941 PYDGNSPLDRYIIEFKRSRAS---WSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQ 1002
            ..|.|||:::|.|||:....:   |..:.:  |||:.|...: ||||...|..|:.|.|..|:.:
  Rat   637 AEDHNSPIEKYDIEFEDKEMAPEKWFSLGK--VPGNQTSTTL-KLSPYVHYTFRVTAINKYGSGE 698

  Fly  1003 SSE-AVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYV 1066
            .|. :.|::|.|.||...|.:::.|......|.:||||....:||...:.|.|.::......::.
  Rat   699 PSPVSETVVTPEAAPEKNPVDVRGEGNETNNMVITWKPLRWMDWNAPQIQYRVQWRPLGKQETWK 763

  Fly  1067 FETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACT 1131
            .:|::       :..|.:.|...:..|.:.:||.|..|.||..:....::.|..|...|.....|
  Rat   764 EQTVS-------DPFLVVSNTSTFVPYEIKVQAVNNQGKGPEPQVTIGYSGEDYPQVSPELEDIT 821

  Fly  1132 TLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWY-----DETKRHYKKT------ASSDTVL 1185
            ...|.|:.|.|....|....|.::.|.|.|     |:     ..:|||..|:      .::..:|
  Rat   822 IFNSSTVLVRWRPVDLAQVKGHLRGYNVTY-----WWKGSQRKHSKRHVHKSHMVVPANTTSAIL 881

  Fly  1186 HGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNG 1250
            .||:.|::|.::|.|....|.|..| .....|...||..|..:......:.::|:.|:||...||
  Rat   882 SGLRPYSSYHVEVQAFNGRGLGPAS-EWTFSTPEGVPGHPEALHLECQSDTSLLLHWQPPLSHNG 945

  Fly  1251 IITQYTV-YSKAEG----------AETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEG 1304
            ::|.|.: |...:|          ::.|.:|..:         |.|..:..|.|.:.|:|..|.|
  Rat   946 VLTGYLLSYHPLDGESKEQLFFNLSDPELRTHNL---------TNLNPDLQYRFQLQATTQQGPG 1001

  Fly  1305 QQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRV- 1368
            :               .|.....|.....|.|.....:..|.....::|..:  |...|.|..:
  Rat  1002 E---------------AIVREGGTMALFGKPDFGNISVTAGENYSVVSWVPR--EGQCNFRFHIL 1049

  Fly  1369 ---LPDGSLLIKSVNRQDAGDYSCHAENS----------------IAKDSITHKLIVLAPPQSPH 1414
               ||:|.:   |.:.|....|..:.::|                :.:..:.|.|.|......|
  Rat  1050 FKALPEGKV---SPDHQPQPQYVSYNQSSYTQWDLQPDTKYEIHLMREKVLLHHLAVKTNGTGP- 1110

  Fly  1415 VTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLC------G 1473
            |.:|.|.:.|       .||                  |..:.||.......|..:||      |
  Rat  1111 VRVSTTGSFA-------SEG------------------WFIAFVSAIILLLLILLILCFIKRSKG 1150

  Fly  1474 SRYQV----------YATGFNNIGAGEASDILNTRTKGQKPKL--PEKPRFIEVS----SNSVSL 1522
            .:|.|          .|....:...||.||.........:|.|  ..||...:.|    ..||.:
  Rat  1151 GKYSVKDKEDTQVDSEARPMKDETFGEYSDNEEKAFGSSQPSLNGDIKPLGSDDSLADYGGSVDV 1215

  Fly  1523 HFKAWKDGGCPMSHFVVE---SKKRDQIEWNQISNNVKPDNNYVVLD 1566
            .|.  :||.     |:.:   .|:::....|..|....|.|..|.|:
  Rat  1216 QFN--EDGS-----FIGQYSGKKEKEAAGGNDSSGATSPINPAVALE 1255

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.