DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam1 and dpr12

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_652462.3	Gene:	dpr12 / 50320	FlyBaseID:	FBgn0085414	Length:	326	Species:	Drosophila melanogaster

Alignment Length:	295	Identity:	61/295 - (20%)
Similarity:	106/295 - (35%)	Gaps:	83/295 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 TAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLRIESVKKEDKGMYQ 408
            |..|:..::|..:::           .|.|..|.: ||:.| ..|.|:....::|   .|..|::
  Fly    30 TLLLATTLEPDQKSI-----------LTDNDWKKL-WMRGG-INGDSKLDNNLDS---SDSPMFE 78

  Fly   409 CFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWE------ 467
                 |.|....:..::|||                    :.||.|...|.....::|.
  Fly    79 -----DSELMAHNTTVQLGG--------------------TAFLVCKVSGVDRVGVNWNQISWIR 118

  Fly   468 -------LDGKKIANND-RYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAK 524
                   ..|.::..|| |:.:   :...|..:..|.|..|...|.|:|:|...:..|:..|...
  Fly   119 RRDWHILSSGAQLYTNDERFAI---LHTPGSNMWTLQIKFVQRRDHGMYECQVSTPTGIISHFVN 180

  Fly   525 LNVYGLP--YIRQMEKKAIVAGETLIVTCPV--AGYPIDSIVWERDNRAL--------------P 571
            |.|. :|  :|....:..:..|.|:.:.|.:  :..|...:.|::::|.:              |
  Fly   181 LQVV-VPEAFILGSGELHVDMGSTINLVCIIEKSPTPPQYVYWQKNDRLINYVDSRRDITIETTP 244

  Fly   572 INRKQKVFPNGTLIIENVERNSDQATYTCVAKNQE 606
            ..|.|     ..|||.. .:.:|...|||.|.|.|
  Fly   245 GPRTQ-----SRLIIRE-PQVTDSGNYTCSASNTE 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653	14/71 (20%)
		IGc2	361..413	CDD:197706	11/51 (22%)
		I-set	433..527	CDD:254352	20/107 (19%)
		IGc2	446..517	CDD:197706	17/84 (20%)
		I-set	533..618	CDD:254352	20/90 (22%)
		IGc2	544..607	CDD:197706	19/79 (24%)
		Ig	641..714	CDD:143165
		IGc2	735..804	CDD:197706
		I-set	819..914	CDD:254352
		Ig	833..921	CDD:299845
		FN3	918..1011	CDD:238020
		FN3	1018..1116	CDD:238020
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
dpr12	NP_652462.3	IG	86..183	CDD:214652	23/119 (19%)
		Ig_3	193..271	CDD:404760	17/83 (20%)
		Ig strand B	204..208	CDD:409353	0/3 (0%)
		Ig strand C	219..223	CDD:409353	0/3 (0%)
		Ig strand E	250..254	CDD:409353	1/3 (33%)
		Ig strand F	264..269	CDD:409353	3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900