DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam1 and negr1

DIOPT Version :9

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:XP_009300786.1 Gene:negr1 / 445374 ZFINID:ZDB-GENE-040822-27 Length:360 Species:Danio rerio


Alignment Length:355 Identity:85/355 - (23%)
Similarity:150/355 - (42%) Gaps:84/355 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   311 LIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDF-----------GRPA 364
            :.::||.|  ||::|..:           :|::...|.:.: |..||||:           |..|
Zfish     5 IAVQDACV--SGQWLTAI-----------ILSLCCFLPSCL-PAGQTVDYTTSSESVVSRQGDTA 55

  Fly   365 VFTCQ-----------------YTGNPIKTVSWMKDGKA-----IGHS-EPVLRIESVKKEDKGM 406
            :..|.                 |.||.    .|..|.:.     :|.. |..|:|:.|...|:|:
Zfish    56 LLRCYLLDGISKGAWLNRSSIIYAGND----KWSGDPRVSIVSNVGDKHEYSLQIQKVDVTDEGV 116

  Fly   407 YQCFVRNDQESAEASAEL--KLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELD 469
            |.|.:::::.......:|  |:     ||.|.....:.|:..|.:|.|.|.|.|.|.|:|||   
Zfish   117 YTCSIQSERNLHPKLIQLIVKV-----PPKIYDISSDITVNEGSNVSLICAASGKPEPKISW--- 173

  Fly   470 GKKIANNDR-YQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAE-HSAKLNVYGLPY 532
             :.|:.:.| |:.|:          |||||.:..:..|.|:|.|::.:...: .:.::.|...|.
Zfish   174 -RHISPSARKYESGE----------YLNITGISRDQAGDYECGAENDIASPDTKTVRVTVNFPPA 227

  Fly   533 IRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPN-----GTLIIENVERN 592
            |.:|:...:..|:..::.|..|..|.....|.:..:.  ||..|.:..|     ..|.::|:.::
Zfish   228 IHEMKSHGVRPGQVALLRCEAAAVPSPVFEWYKGEKR--INMGQGIVINNLSSRSVLTVKNMTQD 290

  Fly   593 SDQATYTCVAKNQEGYSARGSLEVQVMVLP 622
            . ...|||||.|:.| :|..|:.:..::.|
Zfish   291 R-YGNYTCVAVNRLG-TANASVPLNPIIEP 318

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 Ig 38..130 CDD:299845
IG 57..133 CDD:214652
IG_like 267..343 CDD:214653 7/31 (23%)
Ig 269..340 CDD:143165 6/28 (21%)
IG_like 353..425 CDD:214653 23/107 (21%)
IGc2 361..413 CDD:197706 17/74 (23%)
I-set 433..527 CDD:254352 27/95 (28%)
IGc2 446..517 CDD:197706 24/71 (34%)
I-set 533..618 CDD:254352 22/89 (25%)
IGc2 544..607 CDD:197706 17/67 (25%)
Ig 641..714 CDD:143165
IGc2 735..804 CDD:197706
I-set 819..914 CDD:254352
Ig 833..921 CDD:299845
FN3 918..1011 CDD:238020
FN3 1018..1116 CDD:238020
FN3 1124..1217 CDD:238020
FN3 1222..1312 CDD:238020
Ig 1339..1406 CDD:299845
FN3 1409..1499 CDD:238020
FN3 1504..1584 CDD:238020
Dscam_C 1890..2008 CDD:289151
negr1XP_009300786.1 Ig 42..121 CDD:299845 17/82 (21%)
IG_like 44..136 CDD:214653 18/95 (19%)
I-set 140..222 CDD:254352 27/95 (28%)
IGc2 153..208 CDD:197706 24/68 (35%)
IG_like 236..312 CDD:214653 20/79 (25%)
IGc2 238..304 CDD:197706 17/68 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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