DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and Cont

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster

Alignment Length:	1369	Identity:	286/1369 - (20%)
Similarity:	474/1369 - (34%)	Gaps:	369/1369 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 WIRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDY------------RQEVH--AQVYACL----- 118
            |:..|.|.:..:..  ..|.|.::   |...||.            .|.::  .|.|..|
  Fly   213 WVNDDNTQLVQIED--SFSMDEQV---PLENEDLHDNRFLVQNDLNNQNINNPNQFYNSLPGTVN 272

  Fly   119 ARNQ------------FGSIISRDVHVRAVVSQHYEED---IHKAFVIRGNSAILKCDIPSFVAD 168
            .|||            :|.  :|.|..|.|.:...:.|   ...|:.|..|..|.:..: .:.:|
  Fly   273 QRNQNNLRGFIGPNQPYGD--NRYVRDRVVYAFSKKRDRWMFMPAYEIELNLFICESKV-LYSSD 334

  Fly   169 FVNVISWHSDEKENFYPGTEYDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATK 233
            .||:   ..|:|..::.|.:.:....: |.|...:::  |.|                |.....|
  Fly   335 NVNI---KLDDKRPYHYGLDINDMERI-PRGPYFVKQ--PND----------------TTFDVNK 377

  Fly   234 GRLVITEPVGSVSPQLSGNGNQEHITLTRVPKMGSVTLMCPAQAYPVPFFRWYK--FIEGTTRKQ 296
            .||:                             ..|||.|.|..||.|.:.||:  :::.....|
  Fly   378 NRLI-----------------------------NDVTLSCLANGYPTPSYTWYREVYVDDRLEYQ 413

  Fly   297 AV--VLNDRVKQVSGTLII---KDAVVEDSGKYLCVVNNSVG---GESVETVLTVTAPLSAKIDP 353
            .:  :..||.....|.|||   |.|:  |.|.|.||..|..|   .||...........:.|...
  Fly   414 KIDPLAQDRYTISGGNLIIYEPKQAL--DQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLKRSA 476

  Fly   354 PTQTVDFGRPAVFTCQYTGNPIKTVSWMK---------DGKAIGHSEPVLRIESVKKEDKGMYQC 409
            .|..:::|: ::|.......|.....|.:         |.:.....:..|....::..|:..|.|
  Fly   477 ETSEMNWGK-SIFCDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRDGALYFSFIETVDRANYSC 540

  Fly   410 FVRNDQESAEASAELKLGGRFDP----P-------VIRQAFQE---ETMEPGPSVFLKCVAGGNP 460
            .|:.      ..::....|.|.|    |       :....|.:   |....|..:.|:|:|.|.|
  Fly   541 TVQT------LVSDTGRNGPFFPLRVTPNSNYQALIFANTFPKVFPEAPVAGDEIRLECMAFGYP 599

  Fly   461 TPEISWELDGKKIANNDRYQVGQYVTVN-GDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAK 524
            .|..:|...|..:..|       ..|:| |.|:...|.|:   ||.|.|.|...:.......|..
  Fly   600 IPSYNWTRQGLPLQRN-------AYTINYGRVLIIQNATT---NDNGEYSCTITNPRKTLMKSIY 654

  Fly   525 LNVYGLPYIRQMEKKAIVAGETLI------VT--CPVAGYPIDSIVWERDNRALP---INRKQKV 578
            :|:       ||..:..:..:.:|      ||  |.....|..:..|.::...|.   |||.:.:
  Fly   655 INI-------QMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYI 712

  Fly   579 FPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVLPQIVPFAYEDLINMGDSIDLFC 643
            ..:..|.|:.:|::.|.|.|.|.|:||
  Fly   713 IQDNVLTIKFLEKDKDDAMYQCGAQNQ-------------------------------------- 739

  Fly   644 QIQKGDRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKTSMISIPSASPAHTGRDTCIASNKAG 708
                    :|..:|             ..|:|.  :|.|.|....|..|..:...:        |
  Fly   740 --------LKTSFS-------------SAQLRV--LSMKPSFKKHPLESEVYAVYN--------G 773

  Fly   709 TTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKK---AVGDTPGEYKDLK 770
            .||                             :.|..:..|:|:..|||   .:|.  |.::.:.
  Fly   774 NTT-----------------------------IVCDPEAAPRPKFQWKKDGQVIGS--GGHRRIL 807

  Fly   771 KSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLS--AVIMIS----VQAPPEFTEKLRNQT 829
            .|       |||.:....:.:||.|.|.|.|..|:..|  .||::.    ::.||:      ...
  Fly   808 PS-------GTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQ------RIV 859

  Fly   830 ARRGEPAVLQCEAKGEK--PIGILWNMNNMRLDPKNDNRYTIREEILSTGVM----SSLSIKRTE 888
            ::..:...|.|||..::  .|..:|..|...|...:|          .||.:    :.|::..|.
  Fly   860 SKEHDLIFLHCEAAFDELLDIAYVWKHNGEVLKNNHD----------GTGRIIVDWNRLTVHNTS 914

  Fly   889 RSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDG--NSPLDRY 951
            ..|:..:.||..:|.....:..::.::..|..|..::|:..|.....:.|.   ||  |....||
  Fly   915 MRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWV---DGSHNGRAIRY 976

  Fly   952 --IIEFKRSRASWS-------------EIDRVIVPGHTT--EAQVQKLSPATTYNIRIVAENAIG 999
              |:    .|.:|:             |:||     :|:  :|:|..|:|.:.|...:.|.|.:|
  Fly   977 YNIL----GRTNWNRTWVNVSTHVQAREVDR-----YTSRQQAEVVNLTPWSAYEFSVTAVNDLG 1032

  Fly  1000 TSQSSEAVTII-TAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNS 1063
            ....|....|. |.|:.|...|:|:.........:.:||.|....|.:...:.|.|.:||..
  Fly  1033 IGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKG--- 1094

  Fly  1064 SYVFETINFITEEGKEH--------NLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGT 1120
                 .|.:.::|.|:.        |:.|.|  .||:|.|.:||.|.:|.||.||.....:||..
  Fly  1095 -----AIEWASDEIKKQDHMGVAVVNIPLNN--YYTEYEVKVQAINSVGKGPESEIAVIHSAEDM 1152

  Fly  1121 PSQPPSDTACTTLTSQTIRVGW--VSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDT 1183
            |...|.........|....|.|  :....|:..|.:..:::.|..:....:::..:..:|..:..
  Fly  1153 PQVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWA 1217

  Fly  1184 VLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPE-APTDVKALVMGNAAILVSWR--PP 1245
            ::.||:..|.|.::|:|..|.|:|..|.....:|....|: .|:.|....:..:.:.|.||  .|
  Fly  1218 LIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSP 1282

  Fly  1246 AQPNGIITQYTV--YSKAEGAETETKT-----QKVPHYQMSFEATELEKNKPYEFWVTASTTIGE 1303
            :|....:..|.|  :...:...|...|     ||:..|     ...|...|.|...|.|.:..|:
  Fly  1283 SQDEEPVEGYKVRIWESDQNMITANNTIVPIGQKLESY-----INNLTPGKSYNMRVLAYSNGGD 1342

  Fly  1304 GQQS 1307
            |:.|
  Fly  1343 GRMS 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845	16/87 (18%)
		IG	57..133	CDD:214652	18/90 (20%)
		IG_like	267..343	CDD:214653	28/85 (33%)
		Ig	269..340	CDD:143165	28/80 (35%)
		IG_like	353..425	CDD:214653	11/80 (14%)
		IGc2	361..413	CDD:197706	10/60 (17%)
		I-set	433..527	CDD:254352	25/104 (24%)
		IGc2	446..517	CDD:197706	21/71 (30%)
		I-set	533..618	CDD:254352	22/95 (23%)
		IGc2	544..607	CDD:197706	20/73 (27%)
		Ig	641..714	CDD:143165	12/72 (17%)
		IGc2	735..804	CDD:197706	18/71 (25%)
		I-set	819..914	CDD:254352	18/100 (18%)
		Ig	833..921	CDD:299845	18/93 (19%)
		FN3	918..1011	CDD:238020	27/112 (24%)
		FN3	1018..1116	CDD:238020	28/105 (27%)
		FN3	1124..1217	CDD:238020	18/94 (19%)
		FN3	1222..1312	CDD:238020	23/96 (24%)
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Cont	NP_649461.2	CLECT	139..>223	CDD:214480	3/9 (33%)
		Ig	361..460	CDD:299845	34/147 (23%)
		I-set	362..462	CDD:254352	34/148 (23%)
		Ig	466..559	CDD:299845	15/99 (15%)
		IG_like	584..657	CDD:214653	22/82 (27%)
		IGc2	586..645	CDD:197706	21/68 (31%)
		Ig	667..751	CDD:299845	23/142 (16%)
		IG_like	676..751	CDD:214653	22/133 (17%)
		IG_like	765..844	CDD:214653	25/124 (20%)
		Ig	773..844	CDD:299845	24/108 (22%)
		I-set	851..940	CDD:254352	19/104 (18%)
		Ig	866..944	CDD:299845	17/87 (20%)
		FN3	944..1043	CDD:238020	26/110 (24%)
		FN3	1053..1146	CDD:238020	28/102 (27%)
		fn3	1156..1244	CDD:278470	17/87 (20%)
		fn3	1259..1346	CDD:278470	21/91 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010