DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam1 and LSAMP

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_001305844.1	Gene:	LSAMP / 4045	HGNCID:	6705	Length:	361	Species:	Homo sapiens

Alignment Length:	333	Identity:	86/333 - (25%)
Similarity:	140/333 - (42%)	Gaps:	34/333 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   620 VLPQIVPFAYEDL--------INMGDSIDLFCQIQKGDRPIKVHWSFERSAGDY-GFDQ--VQPQ 673
            :||..:|....|.        :..||:..|.|.::  |:..||.| ..||...: |.|:  :.|:
Human    22 LLPTGLPVRSVDFNRGTDNITVRQGDTAILRCVVE--DKNSKVAW-LNRSGIIFAGHDKWSLDPR 83

  Fly   674 MRTNRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSD 738
            :...:.......:.|........|..||....:....|..|.|.|.|||:.....:|....:||:
Human    84 VELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSN 148

  Fly   739 AKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGI 803
            ..:.|.|:|.|:|.:||:. :..|..|::.         ||..|.:..|.:...|.|.|:|.|.:
Human   149 VTLVCMANGRPEPVITWRH-LTPTGREFEG---------EEEYLEILGITREQSGKYECKAANEV 203

  Fly   804 GSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYT 868
            .|.....:.::|..||..||...|: |..|..|.|:|||.........|..::.|::..|.
Human   204 SSADVKQVKVTVNYPPTITESKSNE-ATTGRQASLKCEASAVPAPDFEWYRDDTRINSANG---- 263

  Fly   869 IREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRS 933
              .||.||...|||::..........:||||.|..|..:||:.:..:.:|.:|:.::.:   |.:
Human   264 --LEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFKRVLPTIPHPIQEI---GTT 323

  Fly   934 VQLSWAQP 941
            |......|
Human   324 VHFKQKGP 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352
		IGc2	544..607	CDD:197706
		Ig	641..714	CDD:143165	16/75 (21%)
		IGc2	735..804	CDD:197706	20/68 (29%)
		I-set	819..914	CDD:254352	29/94 (31%)
		Ig	833..921	CDD:299845	25/87 (29%)
		FN3	918..1011	CDD:238020	5/24 (21%)
		FN3	1018..1116	CDD:238020
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
LSAMP	NP_001305844.1	Ig	38..128	CDD:386229	20/92 (22%)
		Ig	132..215	CDD:386229	23/92 (25%)
		Ig_3	219..294	CDD:372822	25/81 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900