DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam1 and dpr10

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_729591.1	Gene:	dpr10 / 39180	FlyBaseID:	FBgn0052057	Length:	408	Species:	Drosophila melanogaster

Alignment Length:	341	Identity:	70/341 - (20%)
Similarity:	119/341 - (34%)	Gaps:	107/341 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   405 GMYQCFVR-----NDQESAEAS------AELKLGGRFDPPVIRQAFQEE-TMEPGPSVFLKCVAG 457
            |:..|:.|     |:..:|||.      :....|.:::.|......... |...|.|.:|.|...
  Fly    14 GLAVCYQRQSVSNNNHNNAEAKPTHAPPSHYPHGHKWNEPYFDLTMPRNITSLVGKSAYLGCRVK 78

  Fly   458 --GNPTPEISWELDGKKIANNDRY--QVGQY---------VTVNGDVVSY-LNITSVHANDGGLY 508
              ||.|  ::|      |.:.|.:  .||.|         .:.:.|:..: |.|......|.|:|
  Fly    79 HLGNKT--VAW------IRHRDLHILTVGTYTYTTDQRFQTSYHRDIDEWTLQIKWAQQRDAGVY 135

  Fly   509 KCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPIN 573
            :|...:: .|..:|..||:..|           :..||..:
  Fly   136 ECQISTQ-PVRSYSVNLNIVDL-----------IDAETSDI------------------------ 164

  Fly   574 RKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSL-----EVQVMVLPQIVPFAYEDL- 632
             .|:.:             :|.|.|  :|:|:...|:....     .:|.:.:|........||
  Fly   165 -MQQYY-------------NDDAFY--IAENRVYQSSNDEFAGMFGPIQTVAVPTATILGGPDLY 213

  Fly   633 INMGDSIDLFCQIQ-KGDRPIKVHW-------SFERSAGDYGFDQVQPQMRTNRISEKTSMISIP 689
            ::.|.:|:|.|.|: ..:.|..:.|       |.|.|.|...|       :|.:..|..|::.|.
  Fly   214 VDKGSTINLTCIIKFSPEPPTHIFWYHQDKVLSEETSGGRLKF-------KTIKSEETKSILLIY 271

  Fly   690 SASPAHTGRDTCIASN 705
            .|...|:|:.:|..||
  Fly   272 DADLLHSGKYSCYPSN 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653	7/30 (23%)
		IGc2	361..413	CDD:197706	3/12 (25%)
		I-set	433..527	CDD:254352	25/108 (23%)
		IGc2	446..517	CDD:197706	20/84 (24%)
		I-set	533..618	CDD:254352	9/89 (10%)
		IGc2	544..607	CDD:197706	8/62 (13%)
		Ig	641..714	CDD:143165	20/73 (27%)
		IGc2	735..804	CDD:197706
		I-set	819..914	CDD:254352
		Ig	833..921	CDD:299845
		FN3	918..1011	CDD:238020
		FN3	1018..1116	CDD:238020
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
dpr10	NP_729591.1	Ig	63..143	CDD:299845	21/88 (24%)
		IG_like	210..297	CDD:214653	24/85 (28%)
		IGc2	217..287	CDD:197706	20/76 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900