back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and L1CAM

DIOPT Version :10

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_000416.1	Gene:	L1CAM / 3897	HGNCID:	6470	Length:	1257	Species:	Homo sapiens

Alignment Length:	1125	Identity:	271/1125 - (24%)
Similarity:	446/1125 - (39%)	Gaps:	186/1125 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 IDPPTQTVDFGRPAV--------FTCQYTGNPIKTVSWMKDGKAIGHSEPVLRIESVKKED---- 403
            ::||..|....|..|        ..|:.:|.|.....|.:||.   |.:|        ||:
Human    32 MEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGV---HFKP--------KEELGVT 85

  Fly   404 -----------------------KGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETME 445
                                   :|:|:||..|...:| .|.|::|.....|...::..:...:|
Human    86 VYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTA-MSHEIRLMAEGAPKWPKETVKPVEVE 149

  Fly   446 PGPSVFLKCVAGGNPTP-----EISWELDGK--KIANNDRYQVGQYVTVNGDVVSYLNITS---- 499
            .|.||.|.|    ||.|     .|.| ::.|  .|..::|..:||    ||::.....:||
Human   150 EGESVVLPC----NPPPSAEPLRIYW-MNSKILHIKQDERVTMGQ----NGNLYFANVLTSDNHS 205

  Fly   500 ---VHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYI----RQMEKKAIVAGETLIVTCPVAGYP 557
               .||:..|....|.|..:.:...:....:...|.:    ........:.|:.|::.|...|:|
Human   206 DYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFP 270

  Fly   558 IDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVLP 622
            ..:|.|.|.:..:|.:|......|.||.:..| ...|...|.|:|:|..| |||.:..|.|...|
Human   271 TPTIKWLRPSGPMPADRVTYQNHNKTLQLLKV-GEEDDGEYRCLAENSLG-SARHAYYVTVEAAP 333

  Fly   623 QIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSF-----ERSAGDYGFDQVQPQMRTNRISEK 682
            ..:......|...|::..|.||:|...:| :|.|..     |..|.|..:          ||...
Human   334 YWLHKPQSHLYGPGETARLDCQVQGRPQP-EVTWRINGIPVEELAKDQKY----------RIQRG 387

  Fly   683 TSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAF--AQGSDAKVECKA 745
            ..::|  :..|:.|....|.|.|:.|....:..:.|...|..||...::.:  .|||.|.:.|||
Human   388 ALILS--NVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKA 450

  Fly   746 DGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAV 810
            .|.|.|.|.|....|.|.     |:.........|||.:.::|..:.|.|.|.|.|. .:.::.:
Human   451 FGAPVPSVQWLDEDGTTV-----LQDERFFPYANGTLGIRDLQANDTGRYFCLAAND-QNNVTIM 509

  Fly   811 IMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPI--GILWNMNNMRLDPKND-NRYTIREE 872
            ..:.|:...:.|:..|:...::|......|:|..:..:  .|.|..:...|....| ::|.|.:
Human   510 ANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIED- 573

  Fly   873 ILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIV----QEVPEMPYA-LKVLDKSGR 932
                   ..|.|...:.||...::|||:......::...::|    ..||.:..: |.:|.:|
Human   574 -------GRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQS-- 629

  Fly   933 SVQLSWAQPYDGNSPLDRYIIEFKRSRAS---WSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVA 994
            .|::||:...|.|:|:::|.|||:....:   |..:.:  |||:.|...: ||||...|..|:.|
Human   630 QVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGK--VPGNQTSTTL-KLSPYVHYTFRVTA 691

  Fly   995 ENAIGTSQSSE-AVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKL 1058
            .|..|..:.|. :.|::|.|.||...|.::|.|....|.|.:||||....:||...:.|.|.::.
Human   692 INKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRP 756

  Fly  1059 SNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQ 1123
            ..|...:..:.::       :..|.:.|...:..|.:.:||.|..|.||..:....::.|..|..
Human   757 QGTRGPWQEQIVS-------DPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQA 814

  Fly  1124 PPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKK------TASSD 1182
            .|.......|.|..:.|.|....|....|.::.|.|.|.........:|||..|      ..::.
Human   815 IPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTS 879

  Fly  1183 TVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQ 1247
            .:|.||:.|::|.::|.|....|.|..| .....|...||..|..:......|.::|:.|:||..
Human   880 VILSGLRPYSSYHLEVQAFNGRGSGPAS-EFTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLS 943

  Fly  1248 PNGIITQYTV--YSKAEGAETETKTQKVPHYQMSF----------EATELEKNKPYEFWVTASTT 1300
            .||::|.|.:  :...||.:.          |:||          ..|:|..:..|.|.:.|:|.
Human   944 HNGVLTGYVLSYHPLDEGGKG----------QLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTK 998

  Fly  1301 IGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDR 1365
            .|.|:   :||........:.|:.|.: .:||..|:..:           ::|..|  |...|.|
Human   999 EGPGE---AIVREGGTMALSGISDFGN-ISATAGENYSV-----------VSWVPK--EGQCNFR 1046

  Fly  1366 MRVLPDGSLLIKSVNRQDAG 1385
            ..:      |.|::..:..|
Human  1047 FHI------LFKALGEEKGG 1060

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.